Results 271 to 280 of about 993,526 (301)

Strategies for RNA folding and assembly

Nature Reviews Molecular Cell Biology, 2004
RNA is structurally very flexible, which provides the basis for its functional diversity. An RNA molecule can often adopt different conformations, which enables the regulation of its function through folding. Proteins help RNAs reach their functionally active conformation by increasing their structural stability or by chaperoning the folding process ...
Schroeder, Renée, Barta, Andrea, Semrad, Katharina   +2 more
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Single-Molecule RNA Folding

Accounts of Chemical Research, 2005
Single-molecule experiments significantly expand our capability to characterize complex dynamics of biological processes. This relatively new approach has contributed significantly to our understanding of the RNA folding problem. Recent single-molecule experiments, together with structural and biochemical characterizations of RNA at the ensemble level,
Gregory, Bokinsky, Xiaowei, Zhuang
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RNA folding: models and perspectives

Current Opinion in Structural Biology, 2003
Intrinsic events during RNA folding include conformational search and metal ion binding. Several experimentally testable models have been proposed to explain how large ribozymes accomplish folding. Future challenges include the validation of these models, and the correlation of experimental results and theoretical simulations.
Tobin R, Sosnick, Tao, Pan
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RNA folding in the presence of counterions

Physical Review E, 2007
We present a general thermodynamic picture of the folding of RNA-like heteropolymer based on the basic physical principles. The Hamiltonian of the model includes all characteristic interactions explicitly. A particular attention is paid to the electrostatic interactions whose role in the RNA folding is known to be crucial.
Yevgeni Sh, Mamasakhlisov, Shura, Hayryan, V F, Morozov, Chin-Kun, Hu   +3 more
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A kinetic model of RNA folding

Biosystems, 1993
The RNA folding process is represented as a Markov process with states corresponding to RNA secondary structures and transition probabilities corresponding to transformations of a secondary structure caused by formation or disintegration of a helix. Transition probabilities (kinetic constants) are determined.
A A, Mironov, V F, Lebedev
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Kinetic Intermediates in RNA Folding

Science, 1994
The folding pathways of large, highly structured RNA molecules are largely unexplored. Insight into both the kinetics of folding and the presence of intermediates was provided in a study of the Mg 2+ -induced folding of the Tetrahymena ribozyme by hybridization of complementary ...
P P, Zarrinkar, J R, Williamson
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RNA folding and combinatory landscapes

Physical Review E, 1993
In this paper we view the folding of polynucleotide (RNA) sequences as a map that assigns to each sequence a minimum-free-energy pattern of base pairings, known as secondary structure. Considering only the free energy leads to an energy landscape over the sequence space. Taking into account structure generates a less visualizable nonscalar landscape,''
Fontana, W., Stadler, P., Bornbergbauer, E., Griesmacher, T., Hofacker, I., Tacker, M., Tarazona, P., Weinberger, E., Schuster, P.   +8 more
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Protein-facilitated RNA folding

Current Opinion in Structural Biology, 1997
In the absence of protein collaborators, both simple and complex RNAs often misfold or are unfolded. Biologically important RNAs solve their folding problem, in part, using the assistance of chaperone and cofactor proteins. Recent work emphasizes several rules for RNA-protein complexes: formation involves induced fit; many large RNAs fold slowly; and ...
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Folding of branched RNA species

Biopolymers, 1998
The global structures of branched RNA species are important to their function. Branched RNA species are defined as molecules in which double-helical segments are interrupted by abrupt discontinuities. These include helical junctions of different orders, and base bulges and loops.
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RNA Folding, Mutation, and Detection

The structure of RNA molecules is absolutely critical to their functions in a biological system. RNA structure is dynamic and changes in response to cellular needs. Within the last few decades, there has been an increased interest in studying the structure of RNA molecules and how they change to support the needs of the cell in different conditions ...
Kaitlin E, Klotz, Kausik, Chakrabarti
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