Results 81 to 90 of about 125,592 (278)

Coiled-Coil Motifs of RNA-Binding Proteins: Dynamicity in RNA Regulation

Frontiers in Cell and Developmental Biology, 2020
Neuronal granules are biomolecular condensates that concentrate high quantities of RNAs and RNA-related proteins within neurons. These dense packets of information are trafficked from the soma to distal sites rich in polysomes, where local protein ...
Lenzie K. Ford, Luana Fioriti
doaj   +1 more source

Structure Formation in Butterfly Scales: Interplay of Genetic Control, Mechanical Instabilities, and Dynamic Material Properties

Advanced Functional Materials, EarlyView.
Butterfly wing scales are intricate cuticular functional nanosctructures. This perspective suggests that spatially varying material properties, cytoskeletal constraints, and growth‐driven mechanical instabilities shape the resulting nanoscale architectures created from single cells.
Anupama Prakash, Victoria Lloyd, Yi Yang, Anna‐Lee Jessop, Anthony McDougal, Primož Pirih, Guillaume Duclos, Andrew Parnell, Mathias Kolle, Nicola J. Nadeau, Bodo D. Wilts   +10 more
wiley   +1 more source

Germ granule-mediated mRNA storage and translational control

RNA Biology
Germ cells depend on specialized post-transcriptional regulation for proper development and function, much of which is mediated by dynamic RNA granules.
Hoang-Anh Pham-Bui, Mihye Lee
doaj   +1 more source

Deciphering molecular mechanisms of phase separation in RNA biology by single-molecule biophysical technologies

Acta Biochimica et Biophysica Sinica, 2023
Ribonucleic acid (RNA) biology has emerged as one of the most important areas in modern biology and biomedicine. RNA and RNA-binding proteins (RBPs) are involved in forming biomolecular condensates, which are crucial for RNA metabolism.
Li Yuchen, Xu Mengmeng, Qi Zhi
doaj   +1 more source

RNA Granules and Stress Granules in Virus Systems

Journal of Bacteriology and Virology, 2012
Viruses initiate a number of cellular stress responses and modulate gene regulation and compartmentalization of RNA upon infection to be successful parasites. Virus infections may induce or impair stress granule (SG) formation to maximize replication efficiency.
openaire   +1 more source

Building RNA–protein granules: insight from the germline [PDF]

Trends in Cell Biology, 2010
The germline originates from primordial embryonic germ cells which give rise to sperm and egg cells and consequently, to the next generation. Germ cells of many organisms contain electron-dense granules that comprise RNA and proteins indispensable for germline development. Here we review recent reports that provide important insights into the structure
Alexey L, Arkov, Andres, Ramos
openaire   +2 more sources

Germ granule compartments coordinate specialized small RNA production

Nature Communications, 2023
AbstractGerm granules are biomolecular condensates present in most animal germ cells. One function of germ granules is to help maintain germ cell totipotency by organizing mRNA regulatory machinery, including small RNA-based gene regulatory pathways. TheC. elegansgerm granule is compartmentalized into multiple subcompartments whose biological functions
Xiangyang Chen, Ke Wang, Farees Ud Din Mufti, Demin Xu, Chengming Zhu, Xinya Huang, Chenming Zeng, Qile Jin, Xiaona Huang, Yong-hong Yan, Meng-qiu Dong, Xuezhu Feng, Yunyu Shi, Scott Kennedy, Shouhong Guang   +14 more
openaire   +3 more sources

Tissue‐Stimulator Platform for Electrically Stimulating Pancreatic β‐Cells for Long‐Term Functional Regulation

Advanced Functional Materials, EarlyView.
We present a tissue‐stimulator platform for seamless electrode integration with pancreatic tissue, applying uniform electrical stimulation through optimized design with biohybrid 3D printing. Advantageous effects of electrical stimulation on β‐cell function were observed, including enhanced calcium signaling, islet morphology, and maturation.
Jihwan Kim, Uijung Yong, Myungji Kim, Jaewook Kim, Yeonggwon Jo, In Kyong Shim, Song Cheol Kim, Jinah Jang   +7 more
wiley   +1 more source

Characterization of an RNA Granule from Developing Brain [PDF]

Molecular & Cellular Proteomics, 2006
In brain, mRNAs are transported from the cell body to the processes, allowing for local protein translation at sites distant from the nucleus. Using subcellular fractionation, we isolated a fraction from rat embryonic day 18 brains enriched for structures that resemble amorphous collections of ribosomes. This fraction was enriched for the mRNA encoding
George, Elvira, Sylwia, Wasiak, Vanessa, Blandford, Xin-Kang, Tong, Alexandre, Serrano, Xiaotang, Fan, Maria, del Rayo Sánchez-Carbente, Florence, Servant, Alexander W, Bell, Daniel, Boismenu, Jean-Claude, Lacaille, Peter S, McPherson, Luc, DesGroseillers, Wayne S, Sossin   +13 more
openaire   +2 more sources

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source