Support of a cucumber mosaic virus satellite RNA maps to a single amino acid proximal to the helicase domain of the helper virus [PDF]
Marilyn J. Roossinck+2 more
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Transcription‐coupled repair: tangled up in convoluted repair
In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher+3 more
wiley +1 more source
The RNA helicase CI from plum pox potyvirus has two regions involved in binding to RNA [PDF]
Andrés Fernández+1 more
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Conserved function of a RasGEF‐mediated pathway in the metabolic compensation of the circadian clock
Metabolic compensation of the circadian clock is essential for stabilizing the period of endogenous timekeeping in environments with significant nutrient fluctuations. In this study, we demonstrate that RasGEF (SOS1)‐mediated signaling, which is influenced by metabolic conditions, supports the robust function of the circadian clock under low glucose ...
Orsolya Sárkány+6 more
wiley +1 more source
A Mutation in the ATP Binding Domain of Rho Alters Its RNA Binding Properties and Uncouples ATP Hydrolysis from Helicase Activity [PDF]
Shalini Pereira, Terry Platt
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Human FASTK preferentially binds single‐stranded and G‐rich RNA
Although FASTK is known to play a role in mRNA biology, the mechanism through which it recognizes RNA has yet to be unraveled. Here, we used purified human FASTK to characterize its RNA‐binding properties in vitro. We found that FASTK prefers ssRNA oligonucleotides containing guanines with the potential to form G‐quadruplexes and binds robustly to any ...
Daria M. Dawidziak+7 more
wiley +1 more source
Leukophysin: an RNA helicase A-related molecule identified in cytotoxic T cell granules and vesicles. [PDF]
Mohamed Abdelhaleem+3 more
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Ras pathways help buffer biological timekeeping against metabolic perturbations
Circadian clocks must be buffered (compensated) against conditions that could affect their rate (period). This figure shows rhythmic peaks of spore formation driven by the clock of the fungus Neurospora: The period is the same under different nutritional conditions in the wild‐type but not in a RasGEF mutant that disrupts an intracellular signaling ...
Patricia Lakin‐Thomas
wiley +1 more source