Results 191 to 200 of about 125,618 (325)

PARP Inhibitors in Genitourinary Cancer: A New Paradigm Beyond Prostate Cancer

open access: yesInternational Journal of Urology, EarlyView.
ABSTRACT Alterations in the homologous recombination repair genes, such as BRCA1 and BRCA2, are prevalent in various cancers, presenting a unique opportunity to develop synthetic lethal strategies that target homologous recombination deficiency (HRD).
Yohei Okuda   +8 more
wiley   +1 more source

The RNA Helicase and Nucleotide Triphosphatase Activities of the Bovine Viral Diarrhea Virus NS3 Protein Are Essential for Viral Replication [PDF]

open access: green, 2000
Baohua Gu   +6 more
openalex   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

open access: yesImmunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu   +24 more
wiley   +1 more source

Crystal structures of the DExH-box RNA helicase DHX9. [PDF]

open access: yesActa Crystallogr D Struct Biol, 2023
Lee YT   +4 more
europepmc   +1 more source

Gaining insights into epigenetic memories through artificial intelligence and omics science in plants

open access: yesJournal of Integrative Plant Biology, EarlyView.
This review explores how artificial intelligence and machine learning predict plant behavior in response to environmental stress by modeling molecular regulatory networks of plant stress responses. Their combined application with omics methods opens new avenues in understanding the functioning of plant memory and future plant memory‐based plant ...
Judit Dobránszki   +8 more
wiley   +1 more source

Matching maternal and paternal experiences underpin molecular thermal acclimation

open access: yesMolecular Ecology, EarlyView.
Abstract The environment experienced by one generation has the potential to affect the subsequent one through non‐genetic inheritance of parental effects. Since both mothers and fathers can influence their offspring, questions arise regarding how the maternal, paternal and offspring experiences integrate into the resulting phenotype.
L. C. Bonzi   +5 more
wiley   +1 more source

Comparative analysis of the molecular starvation response of Southern Ocean copepods

open access: yesMolecular Ecology, EarlyView.
Abstract Large lipid‐storing copepods dominate mesozooplankton biomass in the polar oceans and form a critical link between primary production and higher trophic levels. The ecological success of these species depends on their ability to survive periods of food deprivation in a highly seasonal environment, but the molecular changes that mediate ...
Cory A. Berger   +3 more
wiley   +1 more source

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