Results 261 to 270 of about 125,618 (325)

Role of the DExH Motif of the Japanese Encephalitis Virus and Hepatitis C Virus NS3 Proteins in the ATPase and RNA Helicase Activities

, 2000
Andi Utama, Hiroyuki Shimizu, Futoshi Hasebe, Kouichi Morita, Akira Igarashi, Ikuo Shoji, Yoshiharu Matsuura, Masahiro Hatsu, Kazuhiro Takamizawa, Akio Hagiwara, Tatsuo Miyamura   +10 more
openalex   +1 more source

The mRNA of DEAD Box Protein p72 Is Alternatively Translated into an 82-kDa RNA Helicase [PDF]

, 2002
Heike Uhlmann‐Schiffler, Oliver G. Rößler, H. Stahl   +2 more
openalex   +1 more source

New Pyridobenothiazolone Derivatives Display Nanomolar Pan‐Serotype Anti‐Dengue Virus Activity

ChemMedChem, Volume 20, Issue 13, July 1, 2025.
A ligand‐based strategy is employed, starting from hit compound 2, to develop the C‐2 modified pyridobenzothiazolone 19 as a pan‐serotype nanomolar DENV‐1‐4 inhibitor. Investigations of the mechanism reveal the peculiar ability to abolish the infectivity of virions in a second infection.
Tommaso Felicetti, Chin Piaw Gwee, Kitti Wing Ki Chan, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Satoru Watanabe, Muhammad Danial Bin Mohd Mazlan, Stefano Sabatini, Serena Massari, Oriana Tabarrini, Gianluca Sbardella, Subhash G. Vasudevan, Giuseppe Manfroni   +13 more
wiley   +1 more source

The RNA helicase DHX35 functions as a co-sensor for RIG-I-mediated innate immunity. [PDF]

PLoS Pathog
Qiao Y, Zhu S, Yang N, Zou SS, Gao B, Wu J, Liu C, Li X, Liu YJ, Chen J.   +9 more
europepmc   +1 more source

Ten‐Eleven Translocation Family Proteins: Structure, Biological Functions, Diseases, and Targeted Therapy

MedComm, Volume 6, Issue 7, July 2025.
TET family proteins play a critical role in DNA demethylation, and their mutations and dysregulation contribute to the onset of multiple diseases. With a deeper understanding of the molecular mechanisms of TET involvement in disease, drug therapy targeting TET proteins shows great potential, which provides insights into new therapeutic strategies ...
Junzhi Liang, Xinni Na, Lingbo Meng, Lixia He, Ting Shu, Yuanyuan Fang, Bowen Zhang, Zhongyu Zhao, Cuishan Guo, Tingting Li, Zhijing Na, Da Li, Xue Xiao   +12 more
wiley   +1 more source

The RNA helicase DDX39 contributes to the nuclear export of spliceosomal U snRNA by loading of PHAX onto RNA. [PDF]

Nucleic Acids Res
Taniguchi I, Hirose T, Ohno M.
europepmc   +1 more source

Small Nucleolar RNAs: Biological Functions and Diseases

MedComm, Volume 6, Issue 7, July 2025.
The majority of snoRNAs are derived from the intron region of genes, besides to intronic snoRNAs, some snoRNAs are transcribed as independent genes, often by Pol II or III, these snoRNAs are called intergenic snoRNAs. All of these play a role in the occurrence and progression of various diseases through multiple functions.
Yi Wang, Min Fu, Zaiyong Zheng, Jianguo Feng, Chunxiang Zhang   +4 more
wiley   +1 more source

Advancing Design Strategy of PROTACs for Cancer Therapy

MedComm, Volume 6, Issue 7, July 2025.
A comprehensive update on the PROTAC design, and highlighting the role of artificial intelligence in the PROTAC design for cancer therapy. ABSTRACT Proteolysis targeting chimeras (PROTACs) have emerged as a groundbreaking class of anticancer therapeutics.
Hang Luo, Yuan Tian, Razack Abdullah, Baoting Zhang, Yuan Ma, Ge Zhang   +5 more
wiley   +1 more source

A New Case of Mitochondrial RNA Helicase SUPV3L1-Associated Neurodegenerative Disease: Ataxia, Spasticity, Optic Atrophy, and Skin Hypopigmentation (ASOASH). [PDF]

Genes (Basel)
Tsygankova P, Chistol D, Krylova T, Bychkov I, Tabakov V, Markova T, Dadali E, Zakharova E.   +7 more
europepmc   +1 more source

Visualization of unwinding activity of duplex RNA by DbpA, a DEAD box helicase, at single-molecule resolution by atomic force microscopy

, 2001
Arnon Henn, Ohad Medalia, Shu-Ping Shi, Michal Steinberg, F. Franceschi, Irit Sagi   +5 more
openalex   +1 more source