Results 241 to 250 of about 342,007 (314)

2‐Phenylquinolines Exhibit Anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 Activity Through the Nonstructural Protein 13 Helicase Inhibition

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A SAR study led to the identification of new 2‐phenylquinoline‐based derivatives that exhibit anti‐Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) activity by acting as ATP‐competitive inhibitors of nonstructural protein 13 (nsp13) helicase.
Giada Cernicchi, Maria Giulia Nizi, Roberta Emmolo, Leentje Persoons, Manon Laporte, Dirk Jochmans, Isabella Romeo, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Jacopo Spezzini, Alma Martelli, Simone Brogi, Francesca Esposito, Tommaso Felicetti, Serena Massari, Giuseppe Manfroni, Stefano Sabatini, Gianluca Sbardella, Stefano Alcaro, Johan Neyts, Angela Corona, Enzo Tramontano, Steven De Jonghe, Oriana Tabarrini   +24 more
wiley   +1 more source

The DEAD-box RNA helicase eIF4A is a crucial factor for stem-cell activity and reproduction of the parasite <i>Schistosoma mansoni</i>. [PDF]

Front Cell Infect Microbiol
Welsch S, Puckelwaldt O, Ajmera S, Magari F, Haeberlein S, Grünweller A, Grevelding CG.   +6 more
europepmc   +1 more source

In vitro characterization of the yeast DEAH/RHA RNA helicase Dhr1. [PDF]

J Biol Chem
Lin R, Elmir E, Reynolds MJ, Johnson AW.
europepmc   +1 more source

The RNA helicase HrpA rescues collided ribosomes in E. coli. [PDF]

Mol Cell
Campbell A, Esser HF, Burroughs AM, Berninghausen O, Aravind L, Becker T, Green R, Beckmann R, Buskirk AR.   +8 more
europepmc   +1 more source

An RNA helicase coordinates with iron signal regulators to alleviate chilling stress in Arabidopsis. [PDF]

Nat Commun
Xing Y, Li Y, Gui X, Zhang X, Hu Q, Zhao Q, Qiao Y, Xu N, Liu J.   +8 more
europepmc   +1 more source

DNA binding of an RNA helicase bacterial transcription terminator. [PDF]

Biochem J
Jain S, Behera A, Sen R.
europepmc   +1 more source

Regulatory role of the N-terminal intrinsically disordered region of the DEAD-box RNA helicase DDX3X in selective RNA recognition. [PDF]

Nat Commun
Toyama Y, Takeuchi K, Shimada I.
europepmc   +1 more source

DEAD/H-box RNA helicase 10 promotes pancreatic cancer cell proliferation <i>via</i> ribonucleotide reductase M2. [PDF]

World J Gastrointest Oncol
Qiu ZS, Wang XC, Ma JC, Zhu CL, Hu YL, Da MX.   +5 more
europepmc   +1 more source

Functional investigation of the RNA helicase MOV10 with respect to its interplay with factors involved in nonsense-mediated mRNA decay. [PDF]

J Biol Chem
Xue G, Faber GP, Pommerening LS, Mallick M, Gupta A, Wahl MC, Shav-Tal Y, Chakrabarti S.   +7 more
europepmc   +1 more source