Results 221 to 230 of about 342,007 (314)

Mechanistic insights into recruitment and regulation of the RNA helicase UPF1 in replication-dependent histone mRNA decay. [PDF]

Nat Commun
Machado de Amorim A, Xue G, He W, Dittmers T, Lewandowski S, Perez-Borrajero C, Bethmann J, Mateva N, Krage C, Nandana V, Loll B, Hilal T, Hennig J, Urlaub H, Marzluff WF, Chakrabarti S.   +15 more
europepmc   +1 more source

Family‐level specialization in protein domain insertion architectures

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Domain insertion creates architectures where one domain interrupts another's sequence. Analysis across 2.7 million classified domains reveals that insertions occur in 20% of multidomain proteins, with 331 families exhibiting consistent architectural roles: 162 function exclusively as hosts, while 169 exclusively serve as inserted modules, such
R. Dustin Schaeffer, Rui Guo, Jing Zhang, Qian Cong, Nick V. Grishin   +4 more
wiley   +1 more source

Correction: The multifunctional RNA helicase DDX39A drives glioblastoma progression by modulating WISP1 alternative splicing that induces an immunosuppressive macrophage polarization. [PDF]

Oncogene
Zhang Y, Xue Z, Zhang N, Zhu Y, Wu Y, Lv M, Zhang Z, Mu F, Xing W, Tang Z, Wang C, Xue Z, Zhou W, Liu X, Li X, Bjerkvig R, Huang B, Han M, Wang J, Wang D.   +19 more
europepmc   +1 more source

Advances in Avian Diagnostic Pathology: Current Trends, Challenges and Future Directions: A Review

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
Advances in avian diagnostic pathology integrate histopathology, immunohistochemistry, molecular diagnostics and digital pathology to enhance the detection and management of poultry diseases. Emerging tools, including machine learning and artificial intelligence, further improve diagnostic accuracy, disease surveillance and outbreak prediction.
Gebyaw Menge Getnet, Mengesha Ayehu Getnet, Ayenalem Shibabaw Atenaf   +2 more
wiley   +1 more source

The advances of DEAD-box RNA helicase 17 in chronic non-infectious diseases. [PDF]

Front Cardiovasc Med
Xiong M, Wang Q, Wang T, Li M, Deng X, Wang J, Li, Yang Y, Sun X.   +8 more
europepmc   +1 more source

Exceptional Longevity Modifying Allele APOE2 Promotes DNA Signaling Pathways Resisting Cellular Senescence in Human Neurons

Aging Cell, Volume 25, Issue 5, May 2026.
Neurons expressing APOE2 were more resistant to endogenous DNA damage, activated transcriptional signaling pathways associated with DNA repair, and were resilient to stress‐induced DNA damage and cellular senescence. In contrast, APOE4 neurons exhibited elevated expression of rRNA repetitive elements and were prone to becoming senescent.
Cristian Gerónimo‐Olvera, Stephen M. Scheeler, Carlos Galicia Aguirre, Genesis Vega‐Hormazabal, Daniela Garcia, Long Wu, Natalia Murad, Kevin Schneider, Kenneth A. Wilson, Nikola T. Markov, Sicheng Song, Jesse Simons, Akos A. Gerencser, Emily Parlan, Sean D. Mooney, Eric Verdin, Judith Campisi, Tara E. Tracy, David Furman, Simon Melov, Lisa M. Ellerby   +20 more
wiley   +1 more source

The conserved SEN1 DNA/RNA helicase has multiple functions during yeast meiosis. [PDF]

PLoS Genet
Gaglione R, Pierrakeas L, Wan L, Caradonna J, MacQueen AJ, Luk E, Hollingsworth NM.   +6 more
europepmc   +1 more source

Multi‐Omics Signatures of Organ Clocks in Biological Aging and Disease: A Conceptual Framework for Organ‐Specific Aging Clocks

Aging Cell, Volume 25, Issue 5, May 2026.
Organ‐specific aging clocks integrating genomics, epigenomics, transcriptomics, proteomics, and metabolomics offer a more accurate assessment of biological aging than single‐omics approaches. This review proposes a multi‐omics framework emphasizing tissue data, longitudinal study designs, and clinically meaningful training outcomes to advance the ...
Maria Vasileiou, Gabor Liposits, Bara Barakat, Nam P. Nguyen   +3 more
wiley   +1 more source

Unwinding new therapeutic opportunities in rhabdomyosarcoma: the role of RNA helicase DDX5. [PDF]

Front Cell Dev Biol
Bianconi V, Mozzetta C.
europepmc   +1 more source

Integrated 2D–3D Proteomic Profiling Identifies MLK4 as a Microenvironment‐Responsive Regulator of Chemotherapeutic Resistance in Human Glioblastoma Cells

Biology of the Cell, Volume 118, Issue 5, May 2026.
Glioblastoma U251MG cells were cultured in 2D monolayers and 3D spheroids to model tumor architecture. Comparative LC–MS/MS proteomics identified proteins associated with chemoresistance in 3D conditions. Selected candidates were functionally validated by gene knockdown and drug sensitivity assays to confirm their roles in modulating glioblastoma ...
Wannawat Khotchawan, Pakorn Ruengket, Pakpoom Kheolamai, Sith Sathornsumetee, Chomdao Sinthuvanich, Chanchao Lorthongpanich, Surapol Issaragrisil   +6 more
wiley   +1 more source