The multifunctional RNA helicase DDX39A drives glioblastoma progression by modulating WISP1 alternative splicing that induces an immunosuppressive macrophage polarization. [PDF]
Zhang Y +19 more
europepmc +1 more source
Crystal structures of the DExH-box RNA helicase DHX9. [PDF]
Lee YT +4 more
europepmc +1 more source
SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity
The SARS‐CoV‐2 nucleocapsid (N) protein is not only the specific viral RNA packaging protein, but also acts as an RNA chaperone, facilitating RNA folding. We show that it facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone.
Sabrina Babl +11 more
wiley +1 more source
Dual roles of DEAD-box RNA helicase Brr2 in genome stability regulation. [PDF]
Chen X +9 more
europepmc +1 more source
ABSTRACT Plants are frequently exposed to adverse conditions. Priming, also known as acclimation or hardening, induces stress memory and prepares plants for future challenges by activating defense and protective mechanisms. For this reason, priming is an effective means to maintain plant yield in the face of climate change. Memory behind the priming is
Aslihan Temel, Nihal Gören‐Sağlam
wiley +1 more source
The host RNA helicase DDX6 restricts avian influenza virus replication by targeting viral NP and modulating ISG15. [PDF]
Lu X +15 more
europepmc +1 more source
Oridonin‐Loaded PDA@Gel@GO Nanocapsules Modulate NLRP3 and Epithelial Repair in Colitis
Mechanism of galactosylated carboxymethyl chitosan nanomicelle oral microcapsules delivering oridonin in alleviating colitis via targeting the NLRP3 inflammasome. ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory bowel disease marked by sustained mucosal inflammation and epithelial barrier dysfunction, closely associated with aberrant NOD‐like
Wenbo Yuan +8 more
wiley +1 more source
Dissecting the Interaction Domains of SARS-CoV-2 Nucleocapsid Protein and Human RNA Helicase DDX3X and Search for Potential Inhibitors. [PDF]
Lodola C +6 more
europepmc +1 more source
Graphical abstract illustrating the barrier defense–tolerance framework of reproductive innate immunity. Across the female and male reproductive tracts and the maternal–fetal interface, epithelial barriers, innate sensors, immune cells, and microbial signals are integrated to preserve reproductive homeostasis.
Xianlin Rao +3 more
wiley +1 more source
AMPK modulates a DEAH box RNA-helicase to attenuate TOR signaling and establish developmental quiescence in Caenorhabditis elegans. [PDF]
Rashid S, Roy R.
europepmc +1 more source

