Results 271 to 280 of about 342,007 (314)

The RNA helicase DDX21 activates YAP to promote tumorigenesis and is transcriptionally upregulated by β-catenin in colorectal cancer. [PDF]

Oncogene
Tang W, Yang Y, Fu Z, Xu W, Ou W, Liu F, Du P, Liu CY.   +7 more
europepmc   +1 more source

RNA helicase D1PAS1 resolves R-loops and forms a complex for mouse pachytene piRNA biogenesis required for male fertility. [PDF]

Nucleic Acids Res
Choi H, Zhou L, Zhao Y, Dean J.
europepmc   +1 more source

Correction to "P68 RNA helicase promotes invasion of glioma cells through negatively regulating DUSP5". [PDF]

Cancer Sci
europepmc   +1 more source

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RNA helicase A is necessary for translation of selected messenger RNAs

Nature Structural & Molecular Biology, 2006
RNA helicase A (RHA) is a highly conserved DEAD-box protein that activates transcription, modulates RNA splicing and binds the nuclear pore complex. The life cycle of typical mRNA involves RNA processing and translation after ribosome scanning of a relatively unstructured 5' untranslated region (UTR).
T. Hartman, Shuiming Qian, Cheryl Bolinger, S. Fernandez, Daniel R Schoenberg, K. Boris-Lawrie   +5 more
semanticscholar   +3 more sources

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Nature Immunology, 2004
M. Yoneyama, M. Kikuchi, T. Natsukawa, N. Shinobu, T. Imaizumi, M. Miyagishi, K. Taira, S. Akira, T. Fujita   +8 more
semanticscholar   +3 more sources

Helicase associated 2 domain is essential for helicase activity of RNA helicase A

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2014
RNA helicase A (RHA), a DExD/H box protein, plays critical roles in a wide variety of cellular or viral functions. RHA contains a conserved core helicase domain that is flanked by five other domains. Two double-stranded RNA binding domains (dsRBD1 and dsRBD2) are at the N-terminus, whereas HA2 (helicase associated 2), OB-fold (oligonucleotide- or ...
Li, Xing, Xia, Zhao, Meijuan, Niu, Lawrence, Kleiman   +3 more
openaire   +2 more sources

Nucleolar localization of murine nuclear DNA helicase II (RNA helicase A)

Journal of Cell Science, 1999
ABSTRACT Nuclear DNA helicase II (NDH II) is a highly conserved member of the DEXH superfamily of eukaryotic helicases, whose physiological role is still unclear. To explore the function of NDH II, we studied the intracellular distribution of NDH II of different mammalian species by immunofluorescence and compared these findings with the
S, Zhang, C, Herrmann, F, Grosse
openaire   +2 more sources

Molecular Characterization of Nuclear DNA Helicase II (RNA Helicase A)

2009
Nuclear DNA helicase II (NDH II) was first isolated from calf thymus using a DNA-unwinding assay. Subsequently it has been shown to be a homologue of human RNA helicase A (RHA) and the maleless protein (MLE) from Drosophila. Accordingly, the protein possesses both DNA and RNA unwinding activities.
Suisheng, Zhang, Frank, Grosse
openaire   +2 more sources

Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase.

Journal of Medicinal Chemistry, 2020
Dysregulation of protein translation is a key driver for the pathogenesis of many cancers. Eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase, is a critical component of the eIF4F complex, which regulates cap-dependent ...
J. Ernst, P. A. Thompson, Christian Nilewski, P. Sprengeler, S. Sperry, Garrick K. Packard, Theo D. Michels, A. Xiang, C. Tran, Christopher J. Wegerski, B. Eam, N. Young, S. Fish, Joan W Chen, H. Howard, J. Staunton, Jolene Molter, Jeff Clarine, Andres Nevarez, G. Chiang, J. Appleman, K. Webster, S. Reich   +22 more
semanticscholar   +1 more source