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Targeting DEAD‐box RNA helicases: The emergence of molecular staples
Wiley Interdisciplinary Reviews - RNA, 2022RNA helicases constitute a large family of proteins that play critical roles in mediating RNA function. They have been implicated in all facets of gene expression pathways involving RNA, from transcription to processing, transport and translation, and ...
S. K. Naineni +3 more
semanticscholar +1 more source
Virus Research, 2021
DEAD-box RNA helicases, the largest family of superfamily 2 helicases, are a profoundly conserved family of RNA-binding proteins, containing a distinctive Asp-Glu-Ala-Asp (D-E-A-D) sequence motif, which is the origin of their name.
Mohamed A. M. Ali
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DEAD-box RNA helicases, the largest family of superfamily 2 helicases, are a profoundly conserved family of RNA-binding proteins, containing a distinctive Asp-Glu-Ala-Asp (D-E-A-D) sequence motif, which is the origin of their name.
Mohamed A. M. Ali
semanticscholar +1 more source
Viral sensing by RNA helicases
Virologie, 2020A key aspect of antiviral immunity is the distinction between "self" and "non-self" components. This distinction can be established through the detection of double-stranded RNA (dsRNA), a common sign of viral infection, by cytosolic RNA helicases.
Claire, Rousseau, Carine, Meignin
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Linking the plant stress responses with RNA helicases.
Plant Science, 2020RNA helicases are omnipresent plant proteins across all kingdoms and have been demonstrated to play an essential role in all cellular processes involving nucleic acids.
S. Pandey +3 more
semanticscholar +1 more source
An RNA helicase swirls in lymphangiogenesis
Nature Cell Biology, 2021How lymphatic vessels arise from veins is still poorly understood. A study reports the discovery of a ribosome biogenesis regulator Ddx21 as a previously unappreciated specific factor that is important for the first steps of lymphatic but not blood vessel development. The finding may lead to better strategies to selectively target lymphangiogenesis.
Severin Mühleder, Rui Benedito
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Trends in Biochemical Sciences, 2001
In eukaryotic cells, all aspects of cellular RNA metabolism require putative RNA helicases of the DEAD and DExH protein families (collectively known as DExD/H families). Based on data from biochemical studies of a few of these RNA helicases, they are generally considered to be involved in the unwinding of duplex RNA molecules.
P, Linder, N K, Tanner, J, Banroques
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In eukaryotic cells, all aspects of cellular RNA metabolism require putative RNA helicases of the DEAD and DExH protein families (collectively known as DExD/H families). Based on data from biochemical studies of a few of these RNA helicases, they are generally considered to be involved in the unwinding of duplex RNA molecules.
P, Linder, N K, Tanner, J, Banroques
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Environmental and Experimental Botany, 2019
In plants, RNA helicases play significant roles in growth, development and stress response. In a previous study, a three-fold upregulation of a DEAD-box RNA helicase in a tomato cultivar tolerant to Tomato leaf curl New Delhi virus (ToLCNDV) as compared ...
S. Pandey +8 more
semanticscholar +1 more source
In plants, RNA helicases play significant roles in growth, development and stress response. In a previous study, a three-fold upregulation of a DEAD-box RNA helicase in a tomato cultivar tolerant to Tomato leaf curl New Delhi virus (ToLCNDV) as compared ...
S. Pandey +8 more
semanticscholar +1 more source
Plant RNA helicases: linking aberrant and silencing RNA
Trends in Plant Science, 2009RNA helicases are ATPases that are capable of rearranging RNA and ribonucleoprotein (RNP) structure, and they can potentially function in any aspect of RNA metabolism. The RNA helicase gene family of plant genomes is larger and more diverse than genome families observed in other systems and provides an ideal model for investigation of the physiological
Linder, Patrick, Owttrim, George
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RNA helicases: modulators of RNA structure
Trends in Cell Biology, 1994RNA molecules play an essential role in many cellular processes, often as components of ribonucleoprotein complexes. Like proteins, RNA molecules adopt sequence-specific secondary and tertiary structures that are essential for function; alteration of these structures therefore provides a means of regulating RNA function.
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RNA Helicases: Versatile ATP-Driven Nanomotors
Journal of Nanoscience and Nanotechnology, 2005RNA helicases are a large family of molecular motors that utilize nucleoside triphosphates to unwind RNA duplexes and to remodel RNA protein complexes. In this review, we discuss the structure and function of RNA helicases with an emphasis on the potential application of these enzymes to control conformational changes in nanoassemblies that contain RNA.
Eckhard, Jankowsky +2 more
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