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RNA helicases: modulators of RNA structure
Trends in Cell Biology, 1994RNA molecules play an essential role in many cellular processes, often as components of ribonucleoprotein complexes. Like proteins, RNA molecules adopt sequence-specific secondary and tertiary structures that are essential for function; alteration of these structures therefore provides a means of regulating RNA function.
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Trends in Biochemical Sciences, 2001
In eukaryotic cells, all aspects of cellular RNA metabolism require putative RNA helicases of the DEAD and DExH protein families (collectively known as DExD/H families). Based on data from biochemical studies of a few of these RNA helicases, they are generally considered to be involved in the unwinding of duplex RNA molecules.
Linder P, Tanner NK, Banroques J
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In eukaryotic cells, all aspects of cellular RNA metabolism require putative RNA helicases of the DEAD and DExH protein families (collectively known as DExD/H families). Based on data from biochemical studies of a few of these RNA helicases, they are generally considered to be involved in the unwinding of duplex RNA molecules.
Linder P, Tanner NK, Banroques J
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Helicase associated 2 domain is essential for helicase activity of RNA helicase A
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2014RNA helicase A (RHA), a DExD/H box protein, plays critical roles in a wide variety of cellular or viral functions. RHA contains a conserved core helicase domain that is flanked by five other domains. Two double-stranded RNA binding domains (dsRBD1 and dsRBD2) are at the N-terminus, whereas HA2 (helicase associated 2), OB-fold (oligonucleotide- or ...
Li, Xing +3 more
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RNA helicase A is necessary for translation of selected messenger RNAs
Nature Structural & Molecular Biology, 2006RNA helicase A (RHA) is a highly conserved DEAD-box protein that activates transcription, modulates RNA splicing and binds the nuclear pore complex. The life cycle of typical mRNA involves RNA processing and translation after ribosome scanning of a relatively unstructured 5' untranslated region (UTR).
Tiffiney Roberts, Hartman +5 more
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RNA Helicases and Their Cofactors
2014RNA helicases are proteins that function by melting RNA secondary structures or remodeling ribonucleoprotein complexes. Canonical RNA helicase eIF4A plays an essential role in translation initiation by resolving secondary structures in the 5′ UTR of mRNAs and preparing the mRNA template for ribosome recruitment.
David Shahbazian +4 more
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Molecular Characterization of Nuclear DNA Helicase II (RNA Helicase A)
2009Nuclear DNA helicase II (NDH II) was first isolated from calf thymus using a DNA-unwinding assay. Subsequently it has been shown to be a homologue of human RNA helicase A (RHA) and the maleless protein (MLE) from Drosophila. Accordingly, the protein possesses both DNA and RNA unwinding activities.
Suisheng, Zhang, Frank, Grosse
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Analysis of Cofactor Effects on RNA Helicases
2012RNA helicases are involved in all aspects of RNA metabolism. Since the helicase core is conserved between all helicases, specificity for particular cellular roles must arise from interactions with specific cofactors, which can regulate RNA binding and enzymatic activity.
Crystal, Young, Katrin, Karbstein
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The multiple functions of RNA helicases as drivers and regulators of gene expression
Nature Reviews Molecular Cell Biology, 2016Cyril F Bourgeois +2 more
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