Results 221 to 230 of about 1,270,992 (292)

Family‐level specialization in protein domain insertion architectures

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Domain insertion creates architectures where one domain interrupts another's sequence. Analysis across 2.7 million classified domains reveals that insertions occur in 20% of multidomain proteins, with 331 families exhibiting consistent architectural roles: 162 function exclusively as hosts, while 169 exclusively serve as inserted modules, such
R. Dustin Schaeffer, Rui Guo, Jing Zhang, Qian Cong, Nick V. Grishin   +4 more
wiley   +1 more source

DEAD box RNA helicases are pervasive protein kinase interactors and activators. [PDF]

Genome Res
Hirth A, Fatti E, Netz E, Acebron SP, Papageorgiou D, Švorinić A, Cruciat CM, Karaulanov E, Gopanenko A, Zhu T, Sinning I, Krijgsveld J, Kohlbacher O, Niehrs C.   +13 more
europepmc   +1 more source

Advances in Avian Diagnostic Pathology: Current Trends, Challenges and Future Directions: A Review

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
Advances in avian diagnostic pathology integrate histopathology, immunohistochemistry, molecular diagnostics and digital pathology to enhance the detection and management of poultry diseases. Emerging tools, including machine learning and artificial intelligence, further improve diagnostic accuracy, disease surveillance and outbreak prediction.
Gebyaw Menge Getnet, Mengesha Ayehu Getnet, Ayenalem Shibabaw Atenaf   +2 more
wiley   +1 more source

RNA helicases DDX3X and DDX3Y form nanometer-scale RNA-protein clusters that support catalytic activity. [PDF]

Curr Biol
Yanas A, Shweta H, Owens MC, Liu KF, Goldman YE.   +4 more
europepmc   +1 more source

The nuclear GUCT domain-containing DEAD-box RNA helicases govern gametophytic and sporophytic development in Physcomitrium patens. [PDF]

Plant Mol Biol, 2021
Perroud PF, Demko V, Demko V, Ako AE, Khanal R, Bokor B, Pavlovič A, Jásik J, Johansen W.   +8 more
europepmc   +1 more source

Exceptional Longevity Modifying Allele APOE2 Promotes DNA Signaling Pathways Resisting Cellular Senescence in Human Neurons

Aging Cell, Volume 25, Issue 5, May 2026.
Neurons expressing APOE2 were more resistant to endogenous DNA damage, activated transcriptional signaling pathways associated with DNA repair, and were resilient to stress‐induced DNA damage and cellular senescence. In contrast, APOE4 neurons exhibited elevated expression of rRNA repetitive elements and were prone to becoming senescent.
Cristian Gerónimo‐Olvera, Stephen M. Scheeler, Carlos Galicia Aguirre, Genesis Vega‐Hormazabal, Daniela Garcia, Long Wu, Natalia Murad, Kevin Schneider, Kenneth A. Wilson, Nikola T. Markov, Sicheng Song, Jesse Simons, Akos A. Gerencser, Emily Parlan, Sean D. Mooney, Eric Verdin, Judith Campisi, Tara E. Tracy, David Furman, Simon Melov, Lisa M. Ellerby   +20 more
wiley   +1 more source

Spliceosome RNA Helicase DDX39B [PDF]

, 2020
openaire   +1 more source

Multi‐Omics Signatures of Organ Clocks in Biological Aging and Disease: A Conceptual Framework for Organ‐Specific Aging Clocks

Aging Cell, Volume 25, Issue 5, May 2026.
Organ‐specific aging clocks integrating genomics, epigenomics, transcriptomics, proteomics, and metabolomics offer a more accurate assessment of biological aging than single‐omics approaches. This review proposes a multi‐omics framework emphasizing tissue data, longitudinal study designs, and clinically meaningful training outcomes to advance the ...
Maria Vasileiou, Gabor Liposits, Bara Barakat, Nam P. Nguyen   +3 more
wiley   +1 more source

Mitochondrial RNA Helicases: Key Players in the Regulation of Plant Organellar RNA Splicing and Gene Expression. [PDF]

Int J Mol Sci
Mizrahi R, Ostersetzer-Biran O.
europepmc   +1 more source

Integrated 2D–3D Proteomic Profiling Identifies MLK4 as a Microenvironment‐Responsive Regulator of Chemotherapeutic Resistance in Human Glioblastoma Cells

Biology of the Cell, Volume 118, Issue 5, May 2026.
Glioblastoma U251MG cells were cultured in 2D monolayers and 3D spheroids to model tumor architecture. Comparative LC–MS/MS proteomics identified proteins associated with chemoresistance in 3D conditions. Selected candidates were functionally validated by gene knockdown and drug sensitivity assays to confirm their roles in modulating glioblastoma ...
Wannawat Khotchawan, Pakorn Ruengket, Pakpoom Kheolamai, Sith Sathornsumetee, Chomdao Sinthuvanich, Chanchao Lorthongpanich, Surapol Issaragrisil   +6 more
wiley   +1 more source