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RNA interference technology in crop protection against arthropod pests, pathogens and nematodes.
Pest Management Science, 2018Scientists have made significant progress in understanding and unraveling several aspects of double-stranded RNA (dsRNA)-mediated gene silencing during the last two decades. Now that the RNA interference (RNAi) mechanism is well understood, it is time to
M. Zotti +5 more
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Environmental RNA interference
Trends in Genetics, 2008The discovery of RNA interference (RNAi), the process of sequence-specific gene silencing initiated by double-stranded RNA (dsRNA), has broadened our understanding of gene regulation and has revolutionized methods for genetic analysis. A remarkable property of RNAi in the nematode Caenorhabditis elegans and in some other multicellular organisms is its ...
Jennifer Whangbo, Craig P. Hunter
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Biomolecular Engineering, 2006
In the recent years, RNA interference (RNAi) has emerged as a major regulatory mechanism in eukaryotic gene expression. The realization that changes in the levels of microRNAs are directly associated with cancer led to the recognition of a new class of tumor suppressors and oncogenes.
Andrei L. Gartel, Eugene S. Kandel
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In the recent years, RNA interference (RNAi) has emerged as a major regulatory mechanism in eukaryotic gene expression. The realization that changes in the levels of microRNAs are directly associated with cancer led to the recognition of a new class of tumor suppressors and oncogenes.
Andrei L. Gartel, Eugene S. Kandel
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Accounts of Chemical Research, 2012
Because RNA interference (RNAi) can be applied to any gene, this technique has been widely used for studying gene functions. In addition, many researchers are attempting to use RNAi technology in RNAi-based therapies. However, several challenging and controversial issues have arisen during the widespread application of RNAi including target gene ...
Yuka Matsushita-Ishiodori +1 more
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Because RNA interference (RNAi) can be applied to any gene, this technique has been widely used for studying gene functions. In addition, many researchers are attempting to use RNAi technology in RNAi-based therapies. However, several challenging and controversial issues have arisen during the widespread application of RNAi including target gene ...
Yuka Matsushita-Ishiodori +1 more
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Nanostructured RNAs for RNA Interference
2014We synthesized three types of nanostructured RNAs that induce RNA interference (RNAi): branched RNAs, dumbbell-shaped RNA, and circular double-stranded RNAs. All three nanostructured RNAs were transformed into double-stranded RNA of approximately 20 base pairs when they were treated with nuclease enzymes such as Dicer.
Naoko Abe +4 more
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RNA Interference Mechanisms and Applications in Plant Pathology.
Annual Review of Phytopathology, 2018The origin of RNA interference (RNAi), the cell sentinel system widely shared among eukaryotes that recognizes RNAs and specifically degrades or prevents their translation in cells, is suggested to predate the last eukaryote common ancestor ( 138 ).
C. Rosa +3 more
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2007
Silencing of gene expression by RNA interference (RNAi) has become a powerful tool for functional genomics in mammalian cells. Furthermore, RNAi holds promise as a simple, fast and cost-effective approach to studying mammalian gene function in vivo and as a novel therapeutic approach.
Ralf Kühn, Wolfgang Wurst, S. Streif
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Silencing of gene expression by RNA interference (RNAi) has become a powerful tool for functional genomics in mammalian cells. Furthermore, RNAi holds promise as a simple, fast and cost-effective approach to studying mammalian gene function in vivo and as a novel therapeutic approach.
Ralf Kühn, Wolfgang Wurst, S. Streif
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RNA Interference and Small Interfering RNAs [PDF]
ChemBioChem, 2001 The term aRNA interferenceo (RNAi) was coined after the groundbreaking discovery that injection of double-stranded RNA (dsRNA) into the nematode Caenorhabditis elegans leads to specific silencing of genes highly homologous in sequence to the delivered dsRNA.
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Induction of RNA interference genes by double-stranded RNA; implications for susceptibility to RNA interference [PDF]
Insect Biochemistry and Molecular Biology, 2012 Gene silencing by RNA interference (RNAi) can be a useful reverse genetics tool in eukaryotes. However, some species appear refractory to RNAi. To study the role of the differential expression of RNAi proteins in RNAi, we isolated partial dicer-2, argonaute-2 translin, vasa intronic gene (VIG) and tudor staphylococcus/micrococcal nuclease (TSN) genes ...
Jennifer S Garbutt, Stuart E. Reynolds
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Next-Generation Lipids in RNA Interference Therapeutics.
ACS Nano, 2017RNA is emerging as a potential therapeutic modality for the treatment of incurable diseases. Despite intense research, the advent to clinical utility remains compromised by numerous biological barriers, hence, there is a need for sophisticated delivery ...
Stephanie Rietwyk, D. Peer
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