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Induction of RNA interference genes by double-stranded RNA; implications for susceptibility to RNA interference [PDF]
Insect Biochemistry and Molecular Biology, 2012 Gene silencing by RNA interference (RNAi) can be a useful reverse genetics tool in eukaryotes. However, some species appear refractory to RNAi. To study the role of the differential expression of RNAi proteins in RNAi, we isolated partial dicer-2, argonaute-2 translin, vasa intronic gene (VIG) and tudor staphylococcus/micrococcal nuclease (TSN) genes ...
Jennifer S Garbutt, Stuart E. Reynolds
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Next-Generation Lipids in RNA Interference Therapeutics.
ACS Nano, 2017RNA is emerging as a potential therapeutic modality for the treatment of incurable diseases. Despite intense research, the advent to clinical utility remains compromised by numerous biological barriers, hence, there is a need for sophisticated delivery ...
Stephanie Rietwyk, D. Peer
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Branched RNA nanostructures for RNA interference
Chemical Communications, 2011Branched RNAs with three- or four-way junctions were designed by assembling single-stranded RNA for RNA interference. Human Dicer transformed branched RNAs into about 20 base pairs of double-stranded RNA, which is a standard siRNA species. Our tetramer design provides a potent silencing effect over a period of 5 days.
Kyoko Aikawa +4 more
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2013
This chapter explains the RNA interference (RNAi) machinery that regulates post-transcriptional gene silencing. The RNAi technology is considered a vital tool in basic molecular and cellular genetic research, functional genomics, gene expression profiling, drug discovery, prospective disease targeting, and therapies.
Walker, Thomas D J +2 more
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This chapter explains the RNA interference (RNAi) machinery that regulates post-transcriptional gene silencing. The RNAi technology is considered a vital tool in basic molecular and cellular genetic research, functional genomics, gene expression profiling, drug discovery, prospective disease targeting, and therapies.
Walker, Thomas D J +2 more
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Antisense-RNA regulation and RNA interference
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2002For a long time, RNA has been merely regarded as a molecule that can either function as a messenger (mRNA) or as part of the translational machinery (tRNA, rRNA). Meanwhile, it became clear that RNAs are versatile molecules that do not only play key roles in many important biological processes like splicing, editing, protein export and others, but can ...
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2007
Publisher Summary This chapter discusses the possible roles for RNA interference (RNAi) in the human immunodeficiency virus type 1 (HIV‐1) life cycle and the way in which HIV‐1 might use protein and RNA elements to regulate RNA‐based viral restriction. RNAi can regulate a variety of biological processes.
Le, S, Yeung, ML, Bennasser, Y, Jeang, K
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Publisher Summary This chapter discusses the possible roles for RNA interference (RNAi) in the human immunodeficiency virus type 1 (HIV‐1) life cycle and the way in which HIV‐1 might use protein and RNA elements to regulate RNA‐based viral restriction. RNAi can regulate a variety of biological processes.
Le, S, Yeung, ML, Bennasser, Y, Jeang, K
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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
Nature, 2001Sayda M. Elbashir +5 more
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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Nature, 1998A. Fire +5 more
semanticscholar +1 more source
2012
Each of the cells of which a living body is composed (with a few exceptions, such as spermatozoa, eggs, and anucleated and multinucleated cells) contains an identical set of genes. Yet, their expression is not identical; rather, it is regulated by multiple, complex mechanisms in a spatiotemporal and cell-specific manner.
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Each of the cells of which a living body is composed (with a few exceptions, such as spermatozoa, eggs, and anucleated and multinucleated cells) contains an identical set of genes. Yet, their expression is not identical; rather, it is regulated by multiple, complex mechanisms in a spatiotemporal and cell-specific manner.
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2018
RNA interference (RNAi) is a widely used technique to regulate the expression of genes and proteins with a high degree of specificity that is not easily accessed by traditional pharmacological approaches. For preclinical research on rheumatoid arthritis (RA), silencing of target genes in primary immune cells can be easily achieved by the application of
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RNA interference (RNAi) is a widely used technique to regulate the expression of genes and proteins with a high degree of specificity that is not easily accessed by traditional pharmacological approaches. For preclinical research on rheumatoid arthritis (RA), silencing of target genes in primary immune cells can be easily achieved by the application of
openaire +4 more sources