Results 51 to 60 of about 2,067,543 (238)
Scientific Reports, 2017 Uterine carcinosarcomas (UCSs) are highly aggressive malignancies associated with poor prognoses and limited treatment options. These tumors are hypothesized to develop from the endometrial adenocarcinoma (EAC) through epithelial-mesenchymal transition ...
Jill H. Tseng +8 more
doaj +1 more source
The RNA interference revolution
Brazilian Journal of Medical and Biological Research, 2005 The discovery of double-stranded RNA-mediated gene silencing has rapidly led to its use as a method of choice for blocking a gene, and has turned it into one of the most discussed topics in cell biology.
G. Lenz
doaj +1 more source
Screening Genome Sequences for Known RNA Genes and Motifs [PDF]
, 2015 This methods paper presents computational protocols for the identification of non-coding RNA genes or RNA motifs within genomic sequences. An application to bacterial small RNA is proposed.
arxiv +1 more source
Thrombosis Update, 2021 Objective: Venous thromboembolism (VTE) contributes to morbidity and mortality in women with ovarian cancer. Underlying mechanisms of venous thrombosis in ovarian cancer are not well-understood. The aim of this study was to identify the potential role of
Tomoyuki Sasano +6 more
doaj
Structure-based inhibitor screening of natural products against NSP15 of SARS- CoV-2 revealed Thymopentin and Oleuropein as potent inhibitors [PDF]
arXiv, 2020 Coronaviruses are enveloped, non-segmented positive-sense RNA viruses that have the largest genome among RNA viruses. The genome contains a large replicase ORF encodes nonstructural proteins (NSPs), structural and accessory genes. NSP15 is a nidoviral RNA uridylate-specific endoribonuclease (NendoU) has C-terminal catalytic domain. The endoribonuclease
arxiv
RNA Interference (RNAi)-Based Therapeutics: Delivering on the Promise?
Annual Review of Pharmacology and Toxicology, 2016 A resurgence in clinical trials using RNA interference (RNAi) occurred in 2012. Although there were initial difficulties in achieving efficacious results with RNAi without toxic side effects, advances in delivery and improved chemistry made this ...
Maggie L. Bobbin, J. Rossi
semanticscholar +1 more source
Cell Reports, 2021 Summary: Tumor and stromal interactions consist of reciprocal signaling through cytokines, growth factors, direct cell-cell interactions, and extracellular vesicles (EVs).
Shaolin Ma +16 more
doaj
RNA Interference-Induced Innate Immunity, Off-Target Effect, or Immune Adjuvant?
Frontiers in Immunology, 2017 RNA interference (RNAi) is a natural cellular mechanism that inhibits gene expression in a sequence-specific manner. In the last decade, RNAi has become a cornerstone in basic biological systems research and drug development efforts.
Z. Meng, Mengji Lu
semanticscholar +1 more source
Molecular Systems Biology, 2014 Glutamine can play a critical role in cellular growth in multiple cancers. Glutamine‐addicted cancer cells are dependent on glutamine for viability, and their metabolism is reprogrammed for glutamine utilization through the tricarboxylic acid (TCA) cycle.
Lifeng Yang +18 more
doaj +1 more source
Mixed molecular motor traffic on nucleic acid tracks: models of transcriptional interference and regulation of gene expression [PDF]
arXiv, 2015 RNA polymerase (RNAP) is molecular machine that polymerizes a RNA molecule, a linear heteropolymer, using a single stranded DNA (ssDNA) as the corresponding template; the sequence of monomers of the RNA is dictated by that of monomers on the ssDNA template.
arxiv