Results 221 to 230 of about 389,403 (285)

m6A RNA methylation in mammals [PDF]

, 2014
Arianne Heinrichs
openalex   +1 more source

Development of Dimethylsulfonium Probes for Broad Profiling of Methyllysine Reader Proteins

Advanced Science, EarlyView.
Development of oligoglycine‐based dimethylsulfonium probes for unbiased crosslinking to methyllysine readers. The general probe facilitates profiling of site‐specific methyllysine readers, evaluation of selectivity and activity of reader inhibitors, and global profiling of methyllysine readers.
Jinyu Yang, Yihang Xiao, Yingxiao Gao, Mingxuan Wu   +3 more
wiley   +1 more source

Genetic characteristics and prognosis of m6A RNA methylation regulator in acute myeloid leukemia. [PDF]

Genes Dis
Liao K, Guo D, Hu Y, Wen J, Xu Y, Bai X, Cheng J, Zhang B, Wang X.   +8 more
europepmc   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source

m5C RNA methylation in cancer: from biological mechanism to clinical perspectives. [PDF]

Eur J Med Res
Yuan F, Xia Y, Huang Z, Gao H, Bian Y, Zhou X.   +5 more
europepmc   +1 more source

m6A methylation profiling as a prognostic marker in nasopharyngeal carcinoma: insights from MeRIP-Seq and RNA-Seq [PDF]

Xiaochuan Chen, Wenqian Xu, Junping Pan, Hanxuan Yang, Yi Li, Xin Chen, Yingming Sun, Qinying Liu, Sufang Qiu   +8 more
openalex   +1 more source

Multi‐Tissue Genetic Regulation of RNA Editing in Pigs

Advanced Science, EarlyView.
This study presents the first multi‐tissue map of RNA editing and its genetic regulation in pigs. By integrating RNA editing profiles, edQTL mapping, GWAS, and cross‐species comparisons, this work establishes RNA editing as a distinct regulatory layer linking genetic variation to complex traits, highlighting its functional and evolutionary significance.
Xiangchun Pan, Wentao Gong, Xiaodian Cai, Jinyan Teng, Jiali Cai, Haonan Zeng, Wondossen Ayalew, Qingpeng Shen, Zhanming Zhong, Yifei Wang, Wenjing Zhang, Yuhan Tian, Dantong Xu, Yahui Gao, Hongwei Yin, Yuebo Zhang, Jiahui Hou, Tianru Zhou, Jiaqi Li, Lingzhao Fang, Xiaolong Yuan, Zhe Zhang   +21 more
wiley   +1 more source

Dynamic alterations in m⁶A RNA methylation profiles during involution of infantile hemangiomas. [PDF]

Front Oncol
Wu P, Cen Q, Shang Y, Liang J, Ma G.
europepmc   +1 more source

NUDT21‐mediated Alternative Polyadenylation of CDK19 Reprograms Cholesterol Biosynthesis to Drive Colorectal Cancer Progression

Advanced Science, EarlyView.
NUDT21 is overexpressed in colorectal cancer tumors and promotes colorectal cancer progression. NUDT21 promotes the production of a cyclin‐dependent kinase 19 (CDK19) mRNA isoform with a long 3′ UTR, which enhances cytoplasmic export and translation. Truncation of the CDK19 long 3′ UTR phenocopies NUDT21 loss, recapitulating the defects in cholesterol ...
Yeping Yu, Jixin Ma, Minwei Zhou, Xiaodong Gu, Yiming Zhou, Zhenyang Li, Tianyu Zhang, Wei Gong, Chuanxin Huang, Jianbin Xiang   +9 more
wiley   +1 more source

Role of m6A RNA methylation regulators in pancreatic cancer: interactions and potential implications. [PDF]

Cancer Cell Int
Liao L, Xu X, Cao Y, Tang K, Xu Q.
europepmc   +1 more source