Results 211 to 220 of about 250,698 (260)
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Biochemical and Biophysical Research Communications, 1975
Abstract Several plant and animal viral RNAs contain a tRNA like structure at their 3′ ends. In this communication we show that tobacco mosaic virus (TMV) RNA is an acceptable substrate for a specific tRNA methyltransferase. Using a crude preparation of E. coli ribothymidine (rT) forming uracil methylase and (methyl 3H) S-adenosyl-L-methionine (
K, Marcu, B, Dudock
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Abstract Several plant and animal viral RNAs contain a tRNA like structure at their 3′ ends. In this communication we show that tobacco mosaic virus (TMV) RNA is an acceptable substrate for a specific tRNA methyltransferase. Using a crude preparation of E. coli ribothymidine (rT) forming uracil methylase and (methyl 3H) S-adenosyl-L-methionine (
K, Marcu, B, Dudock
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WIREs RNA, 2011
AbstractMethylation of RNA occurs at a variety of atoms, nucleotides, sequences and tertiary structures. Strongly related to other posttranscriptional modifications, methylation of different RNA species includes tRNA, rRNA, mRNA, tmRNA, snRNA, snoRNA, miRNA, and viral RNA.
Yuri, Motorin, Mark, Helm
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AbstractMethylation of RNA occurs at a variety of atoms, nucleotides, sequences and tertiary structures. Strongly related to other posttranscriptional modifications, methylation of different RNA species includes tRNA, rRNA, mRNA, tmRNA, snRNA, snoRNA, miRNA, and viral RNA.
Yuri, Motorin, Mark, Helm
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RNA methylations in human cancers
Seminars in Cancer Biology, 2021RNA methylations, as the prevalent post-transcriptional modifications, are critical in regulating various biological processes, such as RNA transcription, splicing, structure, stability, and translation. Its dysregulation is closely related to the occurrence of human malignancies.
Xiao, Han +4 more
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Methylation of RNA Purine-Bases by Methyl Radicals
Archives of Biochemistry and Biophysics, 1993During the metabolism of 1,2-dimethylhydrazine (a colon carcinogen) in rats, methyl radicals (.CH3) are produced. To gain an insight into the nature of .CH3 interactions with biomolecules in vivo, we conducted in vitro studies using RNA as a model compound.
J O, Kang, K S, Gallagher, G, Cohen
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Journal of Cell Science, 2004
Double-stranded RNAs (dsRNAs) and their `diced' small RNA products can guide key developmental and defense mechanisms in eukaryotes. Some RNA-directed mechanisms act at a post-transcriptional level to degrade target messenger RNAs. However, dsRNA-derived species can also direct changes in the chromatin structure of DNA regions with which they share ...
Mathieu, Olivier, Bender, Judith
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Double-stranded RNAs (dsRNAs) and their `diced' small RNA products can guide key developmental and defense mechanisms in eukaryotes. Some RNA-directed mechanisms act at a post-transcriptional level to degrade target messenger RNAs. However, dsRNA-derived species can also direct changes in the chromatin structure of DNA regions with which they share ...
Mathieu, Olivier, Bender, Judith
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A study of transfer RNA methylation
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973Abstract The process of enzymatic methylation was studied with yeast tRNAVal1, using as a source of enzyme the protein fraction precipitated from the 105 000 × g supernatant of both rat liver and hepatoma by 50 % (NH4)2SO4 saturation. Under the conditions chosen, the extent of methylation with the hepatoma enzyme was about 1 mole of methyl ...
L P, Shershneva +2 more
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Biological roles of adenine methylation in RNA
Nature Reviews Genetics, 2022N6-Methyladenosine (m6A) is one of the most abundant modifications of the epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in detection and mapping methods have improved our understanding of the effects of m6A on mRNA fate and ribosomal RNA function, and have uncovered novel functional roles in virtually every ...
Konstantinos Boulias +1 more
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Nucleolus: A Center of RNA Methylation
Science, 1963The ubiquitously distributed complex of enzymes, the RNA methylases, the apparent function of which is the alteration of the structure of transfer RNA at the macromolecular level by the introduction of methyl groups into the component bases, are concentrated in the nucleolus, an organelle previously implicated in RNA synthesis.
Birnstiel, Max L. +2 more
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RNA Methylation and Control of Eukaryotic RNA Biosynthesis
European Journal of Biochemistry, 1977The role of RNA methylation in the control of ribosome production in mammalian cells has been reinvestigated through a study of the effects in vivo of cycloleucine, a specific and reversible inhibitor of nucleic acid methylations.No close coupling is observed between methylation and transcription.
Caboche, Michel, M., Bachellerie, J.P.
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Plant Molecular Biology, 2000
RNA-DNA interactions can serve as a signal that triggers de novo DNA methylation in plants. As yet, this RNA-directed DNA methylation mechanism merely targets transgenes, but it appears likely that methylation of some endogenous sequences is also directed by RNA.
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RNA-DNA interactions can serve as a signal that triggers de novo DNA methylation in plants. As yet, this RNA-directed DNA methylation mechanism merely targets transgenes, but it appears likely that methylation of some endogenous sequences is also directed by RNA.
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