Results 261 to 270 of about 389,091 (306)

Methylation of TMV RNA

Biochemical and Biophysical Research Communications, 1975
Abstract Several plant and animal viral RNAs contain a tRNA like structure at their 3′ ends. In this communication we show that tobacco mosaic virus (TMV) RNA is an acceptable substrate for a specific tRNA methyltransferase. Using a crude preparation of E. coli ribothymidine (rT) forming uracil methylase and (methyl 3H) S-adenosyl-L-methionine (
K, Marcu, B, Dudock
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RNA m6A methylation across the transcriptome

Molecular Cell, 2023
Since the early days of foundational studies of nucleic acids, many chemical moieties have been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one of these chemical modifications, N6-methyl adenosine (m6A), is unique in a way that it is highly abundant not only on RNA polymerase II (RNAPII) transcribed, protein-coding ...
Erdem, Sendinc, Yang, Shi
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RNA-directed DNA methylation

Plant Molecular Biology, 2000
RNA-DNA interactions can serve as a signal that triggers de novo DNA methylation in plants. As yet, this RNA-directed DNA methylation mechanism merely targets transgenes, but it appears likely that methylation of some endogenous sequences is also directed by RNA.
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Methylation of RNA Purine-Bases by Methyl Radicals

Archives of Biochemistry and Biophysics, 1993
During the metabolism of 1,2-dimethylhydrazine (a colon carcinogen) in rats, methyl radicals (.CH3) are produced. To gain an insight into the nature of .CH3 interactions with biomolecules in vivo, we conducted in vitro studies using RNA as a model compound.
J O, Kang, K S, Gallagher, G, Cohen
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Small Nucleolar RNAs Guide Ribosomal RNA Methylation

Science, 1996
Two recent reports, one in Cell and one in the Journal of Molecular Biology , show that the newly described small nucleolar RNAs control the site of methylation of the ribosomal RNA (rRNA). Tollervey explains how these small RNAs accomplish this targeting and discusses the possible role of ...
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RNA-catalysed guanosine methylation

Nature Catalysis, 2021
Of the few known catalytic RNAs in biology, all but the ribosome involve reactions with phosphodiester bonds. Now, a ribozyme that catalyses a completely different reaction was discovered in all three domains of life.
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Mitochondrial RNA methylation in cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Mitochondria have a complete and independent genetic system with necessary biological energy for cancer occurrence and persistence. Mitochondrial RNA (mt-RNA) methylation, as a frontier in epigenetics, has linked to cancer progression with growing evidences.
Luyi, Tan, Chenyu, Zhu, Xinyu, Zhang, Jiaqi, Fu, Tingting, Huang, Wenji, Zhang, Wenjuan, Zhang   +6 more
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When RNA methylation meets DNA methylation

Nature Genetics, 2022
Wenqi Xu, Hongjie Shen
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Methylated messenger RNA in mouse kidney

Biochemistry, 1975
Polyadenylated messenger RNA from mouse kidney labeled in vivo exhibited a pattern of methylation distinct from that of rRNA and tRNA. After mice were given L-[methyl-3H]methionine, 4% of the polyribosomal RNA label was bound to oligo (dT)-cellulose; 20-24% of orotate- or adenine-labeled polyribosomal RNA eluted in the poly(A)+ RNA fraction under ...
A J, Ouellette, D, Frederick, R A, Malt
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Methylation Modifications in Eukaryotic Messenger RNA

Journal of Genetics and Genomics, 2014
RNA methylation modifications have been found for decades of years, which occur at different RNA types of numerous species, and their distribution is species-specific. However, people rarely know their biological functions. There are several identified methylation modifications in eukaryotic messenger RNA (mRNA), such as N(7)-methylguanosine (m(7)G) at
Jun, Liu, Guifang, Jia
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