Results 261 to 270 of about 1,130,807 (299)

RNA m6A methylation across the transcriptome

Molecular Cell, 2023
Since the early days of foundational studies of nucleic acids, many chemical moieties have been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one of these chemical modifications, N6-methyl adenosine (m6A), is unique in a way that it is highly abundant not only on RNA polymerase II (RNAPII) transcribed, protein-coding ...
Erdem, Sendinc, Yang, Shi
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Nucleolus: A Center of RNA Methylation

Science, 1963
The ubiquitously distributed complex of enzymes, the RNA methylases, the apparent function of which is the alteration of the structure of transfer RNA at the macromolecular level by the introduction of methyl groups into the component bases, are concentrated in the nucleolus, an organelle previously implicated in RNA synthesis.
Birnstiel, Max L., Fleissner, Erwin, Borek, Ernest   +2 more
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Emerging Roles of RNA Methylation in Development

Accounts of Chemical Research, 2023
More than 170 different types of chemical modifications have been identified on diverse types of RNA, collectively known as the epitranscriptome. Among them, N6-methyladenine (m6A), 5-methylcytosine (m5C), N1-methyladenine (m1A), and N7-methylguanosine (m7G) as the ubiquitous post-transcriptional modification are widely involved in regulating the ...
Meng-Ke, Wang, Chun-Chun, Gao, Yun-Gui, Yang   +2 more
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RNA Methylation and Control of Eukaryotic RNA Biosynthesis

European Journal of Biochemistry, 1977
The role of RNA methylation in the control of ribosome production in mammalian cells has been reinvestigated through a study of the effects in vivo of cycloleucine, a specific and reversible inhibitor of nucleic acid methylations.No close coupling is observed between methylation and transcription.
Caboche, Michel, M., Bachellerie, J.P.
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Mitochondrial RNA methylation in cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Mitochondria have a complete and independent genetic system with necessary biological energy for cancer occurrence and persistence. Mitochondrial RNA (mt-RNA) methylation, as a frontier in epigenetics, has linked to cancer progression with growing evidences.
Luyi, Tan, Chenyu, Zhu, Xinyu, Zhang, Jiaqi, Fu, Tingting, Huang, Wenji, Zhang, Wenjuan, Zhang   +6 more
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Studies on the biosynthesis and methylation of transfer RNA

Journal of Molecular Biology, 1964
A rapidly labeled RNA fraction of the nucleolus has been isolated and partially characterized. This RNA component appears to be a precursor of transfer RNA. It contains neither pseudouridine nor methylated bases, and is unable to form amino acyl RNA. However, it resembles transfer RNA in base composition and molecular weight.
D G, COMB, S, KATZ
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Methylation of rat-liver RNA in vivo by methyl methanesulphonate

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1969
Abstract The time-course of methylation of rat-liver RNA in vivo was determined following intraperitoneal injection of a single dose (50–57 mg/kg body weight) of [14C]methyl methanesulphonate. The purified RNA was subjected to acid hydrolysis and the products were separated by ion-exchange chromatography.
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When RNA methylation meets DNA methylation

Nature Genetics, 2022
Wenqi Xu, Hongjie Shen
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The introduction of radioisotopes into RNA by methylation in vitro

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1967
Abstract Either 3 H or 14 C may be introduced at high specific radioactivity into RNA in vitro by treatment with dimethyl sulfate. The procedure is rapid and simple and no degradation of the RNA occurs. The hybridization properties of the methylated RNA compare with those of molecules randomly labeled in vivo .
K D, Smith, J L, Armstrong, B J, McCarthy   +2 more
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Methylation of messenger RNA

Trends in Biochemical Sciences, 1976
Abstract Eukaryotic messenger RNA molecules contain methylated nucleotides, both at their 5′-terminal end in a unique ‘cap' structure, and internally as 6-methyladenylic acid. Similar methylation patterns are.found in heterogeneous nuclear RNA molecules.
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