Results 71 to 80 of about 835,495 (286)

DeepMRMP: A new predictor for multiple types of RNA modification sites using deep learning

Mathematical Biosciences and Engineering, 2019
RNA modification plays an indispensable role in the regulation of organisms. RNA modification site prediction offers an insight into diverse cellular processing.
Pingping Sun, Yongbing Chen, Bo Liu, Yanxin Gao, Ye Han, Fei He , Jinchao Ji   +6 more
doaj   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

The Reverse Transcription Signature of N-\u3csub\u3e1\u3c/sub\u3e-Methyladenosine in RNA-Seq is Sequence Dependent [PDF]

, 2015
The combination of Reverse Transcription (RT) and high-throughput sequencing has emerged as a powerful combination to detect modified nucleotides in RNA via analysis of either abortive RT-products or of the incorporation of mismatched dNTPs into cDNA ...
Alfonzo, Juan, Anderson, James T., Entian, Karl-dieter, Hauenschild, Ralf, Helm, Mark, Hildebrandt, Andreas, Jaschke, Andres, Lafontaine, Denis L.J., Motorin, Yuri, Schmid, Katharina, Sharma, Sunny, Thuring, Kathrin, Tserovski, Lyudmil, Wacheul, Ludvine, Winz, Marie-Luise   +14 more
core   +1 more source

Non-Coding RNA m6A Modification in Cancer: Mechanisms and Therapeutic Targets

Frontiers in Cell and Developmental Biology, 2021
Recently, N6-methyl-adenosine (m6A) ribonucleic acid (RNA) modification, a critical and common internal RNA modification in higher eukaryotes, has generated considerable research interests.
Da-Hong Chen, Ji-Gang Zhang, Chuan-Xing Wu, Qin Li   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source

Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution [PDF]

, 2010
It has recently been shown that nucleosome distribution, histone modifications and RNA polymerase II (Pol II) occupancy show preferential association with exons (“exon-intron marking”), linking chromatin structure and function to co-transcriptional ...
A Barski, A Tyagi, AJ Bannister, Alexander W. Bruce, Anton Wutz, AW Bruce, AW Bruce, B Langmead, B Li, BB Lozzio, BE Bernstein, Christoph M. Koch, CK Lee, CM Koch, Cordelia Langford, David Vetrie, E Allemand, E Batsche, E Birney, EC Forsberg, G Felsenfeld, G Hon, G Nogues, H Tilgner, Ian Dunham, IE Schor, Jackie Bye, JW Larrick, Keith James, Kelly Chiang, KJ Howe, M Allo, M de la Mata, M Yonaha, MC Keogh, MJ Carrozza, N Spies, NA Watkins, ND Heintzman, ND Robson-Dixon, Nicholas A. Watkins, Nicola S. Foad, Nicolas Bonhoure, NJ Park, P Dhami, P Kolasinska-Zwierz, Pawandeep Dhami, Peter Ellis, Peter Saffrey, PG Giresi, PL Nagy, R Andersson, R Landick, RF Luco, RJ Sims, RJ Sims, RK Auerbach, Robert M. Andrews, S Cuddapah, S Nahkuri, S Schwartz, S Schwartz, Shane C. Dillon, T Jenuwein, Willem H. Ouwehand, Y Mito, Z Wang   +66 more
core   +5 more sources

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

A mutate-and-map protocol for inferring base pairs in structured RNA

, 2013
Chemical mapping is a widespread technique for structural analysis of nucleic acids in which a molecule's reactivity to different probes is quantified at single-nucleotide resolution and used to constrain structural modeling.
CS Chow, D Moazed, DH Mathews, EE Regulski, JB Lucks, JG Underwood, JP Staley, KA Wilkinson, M Kertesz, M Mandal, N Kulshina, NB Leontis, P Cordero, P Cordero, P Rocca-Serra, P Tijerina, PJ Lukavsky, R Rydzanicz, RC Spitale, RF Gesteland, S Mitra, S Washietl, S Yoon, SA Mortimer, SE Wells, SM Vasa, SW Brostoff, VD Sood, W Kladwang, W Kladwang, W Kladwang, W Kladwang, Y Rhee   +32 more
core   +1 more source