Results 1 to 10 of about 104,473 (133)
Human Retrovirus Genomic RNA Packaging [PDF]
Viruses, 2022 Two non-covalently linked copies of the retrovirus genome are specifically recruited to the site of virus particle assembly and packaged into released particles.
Heather M. Hanson +3 more
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Reovirus Low-Density Particles Package Cellular RNA [PDF]
Viruses, 2021 Packaging of segmented, double-stranded RNA viral genomes requires coordination of viral proteins and RNA segments. For mammalian orthoreovirus (reovirus), evidence suggests either all ten or zero viral RNA segments are simultaneously packaged in a ...
Timothy W. Thoner +3 more
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Trends Microbiol, 2019 Successful replication of the AIDS retrovirus, HIV, requires that its genomic RNA be packaged in assembling virus particles with high fidelity. However, cellular mRNAs can also be packaged under some conditions. Viral RNA (vRNA) contains a 'packaging signal' (ψ) and is packaged as a dimer, with two vRNA monomers joined by a limited number of base pairs.
Rein A.
europepmc +4 more sources
Coronavirus genomic RNA packaging. [PDF]
Virology, 2019 RNA viruses carry out selective packaging of their genomes in a variety of ways, many involving a genomic packaging signal. The first coronavirus packaging signal was discovered nearly thirty years ago, but how it functions remains incompletely understood.
Masters PS.
europepmc +3 more sources
Sequestering the 5'-cap for viral RNA packaging. [PDF]
Bioessays, 2022 AbstractMany viruses evolved mechanisms for capping the 5′‐ends of their plus‐strand RNAs as a means of hijacking the eukaryotic messenger RNA (mRNA) splicing/translation machinery. Although capping is critical for replication, the RNAs of these viruses have other essential functions including their requirement to be packaged as either genomes or pre ...
Ding P, Summers MF.
europepmc +3 more sources
The impact of local assembly rules on RNA packaging in a T = 1 satellite plant virus. [PDF]
PLoS Computational Biology, 2021 The vast majority of viruses consist of a nucleic acid surrounded by a protective icosahedral protein shell called the capsid. During viral infection of a host cell, the timing and efficiency of the assembly process is important for ensuring the ...
Sam R Hill +2 more
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RNA packaging into extracellular vesicles: An orchestra of RNA-binding proteins? [PDF]
J Extracell Vesicles, 2020 AbstractExtracellular vesicles (EVs) are heterogeneous membranous particles released from the cells through different biogenetic and secretory mechanisms. We now conceive EVs as shuttles mediating cellular communication, carrying a variety of molecules resulting from intracellular homeostatic mechanisms.
Fabbiano F +5 more
europepmc +5 more sources
From Cells to Virus Particles: Quantitative Methods to Monitor RNA Packaging [PDF]
Viruses, 2016 In cells, positive strand RNA viruses, such as Retroviridae, must selectively recognize their full-length RNA genome among abundant cellular RNAs to assemble and release particles.
Mireia Ferrer +4 more
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RNA Encapsidation and Packaging in the Phleboviruses [PDF]
Viruses, 2016 The Bunyaviridae represents the largest family of segmented RNA viruses, which infect a staggering diversity of plants, animals, and insects. Within the family Bunyaviridae, the Phlebovirus genus includes several important human and animal pathogens ...
Katherine E. Hornak +2 more
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Kinetic Studies on the Interaction of HIV-1 Gag Protein with the HIV-1 RNA Packaging Signal [PDF]
VirusesDuring HIV-1 virus assembly, the genomic RNA (vRNA) is selected for packaging by the viral protein Gag because it contains a specific packaging signal, Psi. While there have been numerous studies of Gag–Psi interactions, there is almost no information on
Constance Rink +3 more
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