Results 11 to 20 of about 104,592 (252)
Nucleocapsid protein-dependent assembly of the RNA packaging signal of Middle East respiratory syndrome coronavirus [PDF]
Journal of Biomedical Science, 2018 Background Middle East respiratory syndrome coronavirus (MERS-CoV) consists of a positive-sense, single-stranded RNA genome and four structural proteins: the spike, envelope, membrane, and nucleocapsid protein. The assembly of the viral genome into virus
Wei-Chen Hsin +6 more
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Dimeric RNA recognition regulates HIV-1 genome packaging.
PLoS Pathogens, 2013 How retroviruses regulate the amount of RNA genome packaged into each virion has remained a long-standing question. Our previous study showed that most HIV-1 particles contain two copies of viral RNA, indicating that the number of genomes packaged is ...
Olga A Nikolaitchik +9 more
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Coronavirus genome packaging and nucleocapsid assembly [PDF]
Journal of VirologyCoronaviruses are a family of positive-strand RNA viruses that exhibit highly selective packaging of their genomic RNA (gRNA) into assembled virions, despite the presence of a large excess of subgenomic viral RNA species and host RNA in infected cells ...
Paul S. Masters
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HIV-1 RNA genome packaging: it’s G-rated
mBioA member of the Retroviridae, human immunodeficiency virus type 1 (HIV-1), uses the RNA genome packaged into nascent virions to transfer genetic information to its progeny.
Alice Duchon, Wei-Shau Hu
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Nucleocapsid proteins: roles beyond viral RNA packaging. [PDF]
Wiley Interdiscip Rev RNA, 2016 Viral nucleocapsid proteins (NCs) enwrap the RNA genomes of viruses to form NC–RNA complexes, which act as a template and are essential for viral replication and transcription. Beyond packaging viral RNA, NCs also play important roles in virus replication, transcription, assembly, and budding by interacting with viral and host cellular proteins ...
Ding B, Qin Y, Chen M.
europepmc +4 more sources
The curious case of genome packaging and assembly in RNA viruses infecting plants
Frontiers in Genetics, 2023 Genome packaging is the crucial step for maturation of plant viruses containing an RNA genome. Viruses exhibit a remarkable degree of packaging specificity, despite the probability of co-packaging cellular RNAs.
Tushar Ranjan +9 more
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mBio, 2021 Human immunodeficiency virus type 1 (HIV-1) Gag selects and packages the HIV RNA genome during virus assembly. However, HIV-1 RNA constitutes only a small fraction of the cellular RNA.
Alice Duchon +9 more
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RNA Structures and Their Role in Selective Genome Packaging
Viruses, 2021 To generate infectious viral particles, viruses must specifically select their genomic RNA from milieu that contains a complex mixture of cellular or non-genomic viral RNAs.
Liqing Ye +7 more
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HIV-1 Packaging Visualised by In-Gel SHAPE
Viruses, 2021 HIV-1 packages two copies of its gRNA into virions via an interaction with the viral structural protein Gag. Both copies and their native RNA structure are essential for virion infectivity.
Aaron R. D’Souza +8 more
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Disruption of Specific RNA-RNA Interactions in a Double-Stranded RNA Virus Inhibits Genome Packaging and Virus Infectivity. [PDF]
PLoS Pathogens, 2015 Bluetongue virus (BTV) causes hemorrhagic disease in economically important livestock. The BTV genome is organized into ten discrete double-stranded RNA molecules (S1-S10) which have been suggested to follow a sequential packaging pathway from smallest ...
Teodoro Fajardo, Po-Yu Sung, Polly Roy
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