Results 21 to 30 of about 174,288 (316)
Coronavirus genomic RNA packaging. [PDF]
Virology, 2019 RNA viruses carry out selective packaging of their genomes in a variety of ways, many involving a genomic packaging signal. The first coronavirus packaging signal was discovered nearly thirty years ago, but how it functions remains incompletely understood.
Masters PS.
europepmc +3 more sources
Sequestering the 5'-cap for viral RNA packaging. [PDF]
Bioessays, 2022 AbstractMany viruses evolved mechanisms for capping the 5′‐ends of their plus‐strand RNAs as a means of hijacking the eukaryotic messenger RNA (mRNA) splicing/translation machinery. Although capping is critical for replication, the RNAs of these viruses have other essential functions including their requirement to be packaged as either genomes or pre ...
Ding P, Summers MF.
europepmc +3 more sources
mBio, 2021 Human immunodeficiency virus type 1 (HIV-1) Gag selects and packages the HIV RNA genome during virus assembly. However, HIV-1 RNA constitutes only a small fraction of the cellular RNA.
Alice Duchon +9 more
doaj +1 more source
RNA packaging into extracellular vesicles: An orchestra of RNA-binding proteins? [PDF]
J Extracell Vesicles, 2020 AbstractExtracellular vesicles (EVs) are heterogeneous membranous particles released from the cells through different biogenetic and secretory mechanisms. We now conceive EVs as shuttles mediating cellular communication, carrying a variety of molecules resulting from intracellular homeostatic mechanisms.
Fabbiano F +5 more
europepmc +5 more sources
RNA Structures and Their Role in Selective Genome Packaging
Viruses, 2021 To generate infectious viral particles, viruses must specifically select their genomic RNA from milieu that contains a complex mixture of cellular or non-genomic viral RNAs.
Liqing Ye +7 more
doaj +1 more source
HIV-1 Packaging Visualised by In-Gel SHAPE
Viruses, 2021 HIV-1 packages two copies of its gRNA into virions via an interaction with the viral structural protein Gag. Both copies and their native RNA structure are essential for virion infectivity.
Aaron R. D’Souza +8 more
doaj +1 more source
Disruption of Specific RNA-RNA Interactions in a Double-Stranded RNA Virus Inhibits Genome Packaging and Virus Infectivity. [PDF]
PLoS Pathogens, 2015 Bluetongue virus (BTV) causes hemorrhagic disease in economically important livestock. The BTV genome is organized into ten discrete double-stranded RNA molecules (S1-S10) which have been suggested to follow a sequential packaging pathway from smallest ...
Teodoro Fajardo, Po-Yu Sung, Polly Roy
doaj +1 more source
Specificity of retroviral RNA packaging [PDF]
Journal of Virology, 1991 Encapsidation of retroviral RNA has been shown to be dependent on specific cis-acting signals, in particular, the packaging region (psi) located near the 5' end of the retroviral genome. In this report, we show that a 683-base avian extended packaging sequence (psi+) derived from Rous sarcoma virus will direct packaging of heterologous hygromycin mRNA ...
R, Aronoff, M, Linial
openaire +2 more sources
Packaging signal of influenza A virus
Virology Journal, 2021 Influenza A virus (IAV) contains a genome with eight single-stranded, negative-sense RNA segments that encode 17 proteins. During its assembly, all eight separate viral RNA (vRNA) segments are incorporated into virions in a selective manner.
Xiuli Li +4 more
doaj +1 more source
Murine coronavirus packaging signal confers packaging to nonviral RNA [PDF]
Journal of Virology, 1997 Studies of defective interfering (DI) RNAs of the murine coronavirus mouse hepatitis virus (MHV) suggest that a 69-nucleotide-long packaging signal is necessary for MHV genomic RNA packaging into MHV particles. In this study we showed that when RNA transcripts that consisted of a non-MHV sequence and the packaging signal were expressed in MHV-infected ...
K, Woo +4 more
openaire +2 more sources