Results 31 to 40 of about 104,592 (252)
pyrpipe : a Python package for RNA-Seq workflows [PDF]
NAR Genomics and Bioinformatics, 2020 Abstract The availability of terabytes of RNA-Seq data and continuous emergence of new analysis tools, enable unprecedented biological insight. There is a pressing requirement for a framework that allows for fast, efficient, manageable, and reproducible RNA-Seq analysis.
Urminder Singh +3 more
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Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses
mBio, 2018 Selective packaging is a mechanism used by multiple virus families to specifically incorporate genomic RNA (gRNA) into virions and exclude other types of RNA. Lineage A betacoronaviruses incorporate a 95-bp stem-loop structure, the packaging signal (PS),
Jeremiah Athmer +11 more
doaj +1 more source
Cooperation of an RNA Packaging Signal and a Viral Envelope Protein in Coronavirus RNA Packaging [PDF]
Journal of Virology, 2001 ABSTRACT Murine coronavirus mouse hepatitis virus (MHV) produces a genome-length mRNA, mRNA 1, and six or seven species of subgenomic mRNAs in infected cells. Among these mRNAs, only mRNA 1 is efficiently packaged into MHV particles. MHV N protein binds to all MHV mRNAs, whereas envelope M protein interacts only with mRNA 1. This
K, Narayanan, S, Makino
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Expression of IMP1 enhances production of murine leukemia virus vector by facilitating viral genomic RNA packaging. [PDF]
PLoS ONE, 2010 Murine leukemia virus (MLV)-based retroviral vector is widely used for gene transfer. Efficient packaging of the genomic RNA is critical for production of high-titer virus. Here, we report that expression of the insulin-like growth factor II mRNA binding
Yun Mai, Guangxia Gao
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Modular assembly of chimeric phi29 packaging RNAs that support DNA packaging [PDF]
Biochemical and Biophysical Research Communications, 2008 The bacteriophage phi29 DNA packaging motor is a protein/RNA complex that can produce strong force to condense the linear-double-stranded DNA genome into a pre-formed protein capsid. The RNA component, called the packaging RNA (pRNA), utilizes magnesium-dependent inter-molecular base-pairing interactions to form ring-shaped complexes.
Yun, Fang +4 more
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NMR Studies of Retroviral Genome Packaging
Viruses, 2020 Nearly all retroviruses selectively package two copies of their unspliced RNA genomes from a cellular milieu that contains a substantial excess of non-viral and spliced viral RNAs.
Patricia S. Boyd +12 more
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Alphavirus Nucleocapsid Packaging and Assembly
Viruses, 2018 Alphavirus nucleocapsids are assembled in the cytoplasm of infected cells from 240 copies of the capsid protein and the approximately 11 kb positive strand genomic RNA.
Adriano Mendes, Richard J. Kuhn
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RNA packaging in lentiviruses [PDF]
Retrovirology, 2009 The selection by a lentivirus of its genomic RNA from the background of a vast excess of cellular messenger RNAs and sub-genomic viral RNAs occurs with high specificity. The nature and site of the specific interaction between the unspliced RNA genome and the gag polyprotein, which is responsible for its capture, is still poorly understood and the ...
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Characterization of Coronavirus DI RNA Packaging [PDF]
, 1998 Studies of defective interfering (DI) RNAs of mouse hepatitis virus (MHV), suggest that a 69 nt-long packaging signal, which is located about 20 kb from the 5'-end of the 31 kb-long MHV genomic RNA, is necessary and sufficient for MHV genomic RNA packaging into MHV particles.
K H, Kim, K, Narayanan, S, Makino
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Mechanism of RNA Packaging Motor
, 2011 P4 proteins are hexameric RNA packaging ATPases of dsRNA bacteriophages of the Cystoviridae family. P4 hexamers are integral part of the inner polymerase core and play several essential roles in the virus replication cycle. P4 proteins are structurally related to the hexameric helicases and translocases of superfamily 4 (SF4) and other RecA-like ...
Mancini, E, Tuma, R
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