Results 1 to 10 of about 2,730,472 (338)
Single-peptide DNA-dependent RNA polymerase homologous to multi-subunit RNA polymerase [PDF]
Nature Communications, 2017 Although all known RNA polymerases have multiple subunits, unrelated single-subunit polymerases have also been described. Here, the authors describe a single-subunit RNA polymerase from the SPβ prophage ofBacillus subtilis, which shares homology to multi-
David Forrest +3 more
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Evolution of complex RNA polymerases: the complete archaeal RNA polymerase structure.
PLoS Biology, 2009 The archaeal RNA polymerase (RNAP) shares structural similarities with eukaryotic RNAP II but requires a reduced subset of general transcription factors for promoter-dependent initiation.
Yakov Korkhin +7 more
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Structural Biology of Bacterial RNA Polymerase
Biomolecules, 2015 Since its discovery and characterization in the early 1960s (Hurwitz, J. The discovery of RNA polymerase. J. Biol. Chem. 2005, 280, 42477–42485), an enormous amount of biochemical, biophysical and genetic data has been collected on bacterial RNA ...
Katsuhiko S. Murakami
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Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase
Nature Communications, 2017 The Zika virus outbreak is a global health threat and there is an urgent need for drugs against the virus. Here the authors present the structure of the RNA-dependent RNA-polymerase domain from Zika non-structural protein 5, which is a template for the ...
Andre S. Godoy +6 more
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Abstract P-23: Histone N-terminal Tails Reduce Early Nucleosomal Pausing during Transcription [PDF]
International Journal of Biomedicine, 2021 Background: Nucleosomes are the barriers to transcript elongation by RNA polymerase 2 (Pol 2) in vitro and in vivo. Formation and overcoming the barrier are important for transcription regulation. N-terminal tails of core histones do not affect the inner
Nadezhda S. Gerasimova +2 more
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Abstract P-18: Phosphorylation of RNA Polymerase II C-Terminal Domain Affects Transcript Elongation Through Chromatin [PDF]
International Journal of Biomedicine, 2021 Background: Transcription is the central point of gene regulation where the efficient maintenance of chromatin structure during the passage of RNA polymerase (Pol II) is critical for cell survival and functioning.
Sohail Akhtar +3 more
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Extragenic accumulation of RNA polymerase II enhances transcription by RNA polymerase III. [PDF]
PLoS Genetics, 2007 Recent genomic data indicate that RNA polymerase II (Pol II) function extends beyond conventional transcription of primarily protein-coding genes. Among the five snRNAs required for pre-mRNA splicing, only the U6 snRNA is synthesized by RNA polymerase ...
Imke Listerman +3 more
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Biotechnology & Biotechnological Equipment, 2021 Yeasts Saccharomyces cerevisiae, like other microbes in nature, respond to the unavailability of nutrients with entrance in quiescent/G0 state. These cells exist in non-dividing, latent form by maintaining the cellular metabolism at a low level but still
Asya Vladimirova Daskalova +5 more
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BioTechnologia, 2022 Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected 235.6 million people worldwide. In the present study, RNA-dependent RNA polymerase (RdRp) (PDB Id: 6M71) of SARS-CoV-2, an essential enzyme ...
Nahid Akhtar +5 more
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St. Petersburg Polytechnical University Journal: Physics and Mathematics, 2022 This work presents the results of single-molecular studies of the effect of magnesium ions on the dynamic characteristics of transcription elongation of bacterial RNA polymerase.
Arseniev Anatolii +6 more
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