Results 1 to 10 of about 2,625,316 (382)

Abstract P-18: Phosphorylation of RNA Polymerase II C-Terminal Domain Affects Transcript Elongation Through Chromatin [PDF]

International Journal of Biomedicine, 2021
Background: Transcription is the central point of gene regulation where the efficient maintenance of chromatin structure during the passage of RNA polymerase (Pol II) is critical for cell survival and functioning.
Sohail Akhtar, Elena Y. Kotova, Nadezhda S. Gerasimova, Vasily M. Studitsky   +3 more
doaj   +1 more source

RNA Polymerases of Maize: Nuclear RNA Polymerases [PDF]

Proceedings of the National Academy of Sciences, 1971
Two DNA-dependent RNA polymerases of nuclear origin have been purified from leaves of Zea mays . The two enzymes can be separated on DEAE-cellulose columns. Enzymes I and II are eluted with 0.08 and 0.20 M (NH 4 ) 2 SO 4 , respectively.
Kathleen P. Mullinix, Lawrence Bogorad, Gustave C. Strain   +2 more
openaire   +3 more sources

Single molecules characterization of transcription of bacterial RNA-polymerase parameters using acoustic force spectroscopy

St. Petersburg Polytechnical University Journal: Physics and Mathematics, 2022
This work presents the results of single-molecular studies of the effect of magnesium ions on the dynamic characteristics of transcription elongation of bacterial RNA polymerase.
Arseniev Anatolii, Panfilov Mikhail, Pobegalov Georgii, Potyseva Alina, Pavlinova Polina, Yakunina Maria, Khodorkovskiy Mikhail   +6 more
doaj   +1 more source

Menadione and hydrogen peroxide trigger specific alterations in RNA polymerases profiles in quiescent Saccharomyces cerevisiae cells

Biotechnology & Biotechnological Equipment, 2021
Yeasts Saccharomyces cerevisiae, like other microbes in nature, respond to the unavailability of nutrients with entrance in quiescent/G0 state. These cells exist in non-dividing, latent form by maintaining the cellular metabolism at a low level but still
Asya Vladimirova Daskalova, Anna Atanasova Tomova, Anna Vangelova Kujumdzieva, Lyudmila Georgieva Velkova, Pavlina Aleksandrova Dolashka, Ventsislava Yankova Petrova   +5 more
doaj   +1 more source

Drummondin E and Flinderole B are potential inhibitors of RNA-dependent RNA polymerase of SARS-CoV-2: an in silico study

BioTechnologia, 2022
Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected 235.6 million people worldwide. In the present study, RNA-dependent RNA polymerase (RdRp) (PDB Id: 6M71) of SARS-CoV-2, an essential enzyme ...
Nahid Akhtar, Himanshu Verma, O.M. Silkari, Atul K. Upadhyay, Vikas Kaushik, M. Amin-ul Mannan   +5 more
doaj   +1 more source

Extragenic accumulation of RNA polymerase II enhances transcription by RNA polymerase III. [PDF]

PLoS Genetics, 2007
Recent genomic data indicate that RNA polymerase II (Pol II) function extends beyond conventional transcription of primarily protein-coding genes. Among the five snRNAs required for pre-mRNA splicing, only the U6 snRNA is synthesized by RNA polymerase ...
Imke Listerman, Anita S Bledau, Inna Grishina, Karla M Neugebauer   +3 more
doaj   +1 more source

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

Science, 2020
The COVID-19 RNA-synthesizing machine Many in the scientific community have mobilized to understand the virus that is causing the global coronavirus disease 2019 (COVID-19) pandemic. Gao et al.
Yan Gao, Liming Yan, Yucen Huang, Fengjiang Liu, Yao Zhao, Lin Cao, Tao Wang, Qianqian Sun, Z. Ming, Lianqi Zhang, Ji Ge, Litao Zheng, Ying Zhang, Haofeng Wang, Yan Zhu, Chen Zhu, T. Hu, T. Hua, Bing Zhang, Xiuna Yang, Jun Li, Haitao Yang, Zhijie Liu, Wenqing Xu, L. Guddat, Quan Wang, Z. Lou, Z. Rao   +27 more
semanticscholar   +1 more source

RNA polymerase pushing [PDF]

Biophysical Chemistry, 2011
Molecular motors can exhibit Brownian ratchet or power stroke mechanisms. These mechanistic categories are related to transition state position: An early transition state suggests that chemical energy is stored and then released during the step (stroke) while a late transition state suggests that the release of chemical energy rectifies thermally ...
Eric A. Galburt, Stephan W. Grill, Juan M. R. Parrondo   +2 more
openaire   +4 more sources

RNA Polymerase Unveiled [PDF]

Cell, 1999
The appearance of these structures represents a historic advance in our understanding of one of molecular biology's most remarkable enzymes. Here we have suggested several possible structural bases for key steps in its function. Although speculative, they should serve as stimuli for future work.
Robert Landick, Rachel A. Mooney
openaire   +3 more sources

DNA polymerase III protein, HolC, helps resolve replication/transcription conflicts

Microbial Cell, 2021
In Escherichia coli, DNA replication is catalyzed by an assembly of proteins, the DNA polymerase III holoenzyme. This complex includes the polymerase and proofreading subunits, the processivity clamp and clamp loader complex.
Susan T. Lovett
doaj   +1 more source