Results 1 to 10 of about 1,275,536 (291)
Single-peptide DNA-dependent RNA polymerase homologous to multi-subunit RNA polymerase [PDF]
Nature Communications, 2017 Although all known RNA polymerases have multiple subunits, unrelated single-subunit polymerases have also been described. Here, the authors describe a single-subunit RNA polymerase from the SPβ prophage ofBacillus subtilis, which shares homology to multi-
David Forrest +3 more
doaj +3 more sources
Structure of the bacteriophage PhiKZ non-virion RNA polymerase bound to a p119L open promoter analogue [PDF]
IUCrJBacteriophage ΦKZ (PhiKZ) was the first identified member of a family of massive bacterial viruses. ΦKZ infects Pseudomonas aeruginosa, which kills tens of thousands every year, and it therefore has potential as a bacteriophage therapy. On infection, ΦKZ
Chao-Sheng Chen +3 more
doaj +2 more sources
Abstract P-23: Histone N-terminal Tails Reduce Early Nucleosomal Pausing during Transcription [PDF]
International Journal of Biomedicine, 2021 Background: Nucleosomes are the barriers to transcript elongation by RNA polymerase 2 (Pol 2) in vitro and in vivo. Formation and overcoming the barrier are important for transcription regulation. N-terminal tails of core histones do not affect the inner
Nadezhda S. Gerasimova +2 more
doaj +1 more source
Abstract P-18: Phosphorylation of RNA Polymerase II C-Terminal Domain Affects Transcript Elongation Through Chromatin [PDF]
International Journal of Biomedicine, 2021 Background: Transcription is the central point of gene regulation where the efficient maintenance of chromatin structure during the passage of RNA polymerase (Pol II) is critical for cell survival and functioning.
Sohail Akhtar +3 more
doaj +1 more source
Extragenic accumulation of RNA polymerase II enhances transcription by RNA polymerase III. [PDF]
PLoS Genetics, 2007 Recent genomic data indicate that RNA polymerase II (Pol II) function extends beyond conventional transcription of primarily protein-coding genes. Among the five snRNAs required for pre-mRNA splicing, only the U6 snRNA is synthesized by RNA polymerase ...
Imke Listerman +3 more
doaj +1 more source
Biotechnology & Biotechnological Equipment, 2021 Yeasts Saccharomyces cerevisiae, like other microbes in nature, respond to the unavailability of nutrients with entrance in quiescent/G0 state. These cells exist in non-dividing, latent form by maintaining the cellular metabolism at a low level but still
Asya Vladimirova Daskalova +5 more
doaj +1 more source
DNA polymerase III protein, HolC, helps resolve replication/transcription conflicts
Microbial Cell, 2021 In Escherichia coli, DNA replication is catalyzed by an assembly of proteins, the DNA polymerase III holoenzyme. This complex includes the polymerase and proofreading subunits, the processivity clamp and clamp loader complex.
Susan T. Lovett
doaj +1 more source
BioTechnologia, 2022 Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected 235.6 million people worldwide. In the present study, RNA-dependent RNA polymerase (RdRp) (PDB Id: 6M71) of SARS-CoV-2, an essential enzyme ...
Nahid Akhtar +5 more
doaj +1 more source
St. Petersburg Polytechnical University Journal: Physics and Mathematics, 2022 This work presents the results of single-molecular studies of the effect of magnesium ions on the dynamic characteristics of transcription elongation of bacterial RNA polymerase.
Arseniev Anatolii +6 more
doaj +1 more source
Gene Transcription as a Limiting Factor in Protein Production and Cell Growth
G3: Genes, Genomes, Genetics, 2020 Cell growth is driven by the synthesis of proteins, genes, and other cellular components. Defining processes that limit biosynthesis rates is fundamental for understanding the determinants of cell physiology.
Eyal Metzl-Raz +3 more
doaj +1 more source