Results 161 to 170 of about 2,760,256 (386)

c-Myc induced changes in higher order rDNA structure accompany growth factor stimulation of quiescent cells [PDF]

, 2007
Human c-Myc is believed to be a high level coordinator of protein synthesis capacity and cell growth rate, capable of activating transcription by all three nuclear RNA Polymerases.
Anthony P. H. Wright, Chiou-Nan Shiue, Rachel G. Berkson   +2 more
core   +1 more source

Theory of Nucleosome Corkscrew Sliding in the Presence of Synthetic DNA Ligands

, 2004
Histone octamers show a heat-induced mobility along DNA. Recent theoretical studies have established two mechanisms that are qualitatively and quantitatively compatible with in vitro experiments on nucleosome sliding: Octamer repositiong through one ...
Kulic, Igor M., Mohammad-Rafiee, Farshid, Schiessel, H.   +2 more
core   +2 more sources

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.

Nucleic Acids Research, 1983
J. Dignam, R. Lebovitz, R. Roeder
semanticscholar   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Identification of proteins associated with the yeast mitochondrial RNA polymerase by tandem affinity purification [PDF]

, 2009
Dmitriy Markov, M. V. Savkina, Michael Anikin, Mark Del Campo, Karen Ecker, Alan M. Lambowitz, Jon P. De Gnore, William T. McAllister   +7 more
openalex   +1 more source

Microscopy data: interaction of the gene ripply1 with RNA polymerase II clusters during early zebrafish embryo development

, 2021
Irina Mamontova, Agnieszka Pancholi, Roshan Prizak, Lennart Hilbert   +3 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Suppression by RNA Polymerase I Inhibitors Varies Greatly Between Distinct RNA Polymerase I Transcribed Genes in Malaria Parasites

Pathogens
The transcription of ribosomal RNA (rRNA) by RNA Polymerase I (Pol I) is the rate-limiting step in ribosome biogenesis and a major determinant of cellular growth rates.
Hermela Samuel, Riward Campelo Morillo, Björn F. C. Kafsack   +2 more
doaj   +1 more source

Microscopy data (2/2): interaction of the gene iscub with RNA polymerase II clusters in inhibitor-treated zebrafish embryos

, 2022
Süheyla Eroğlu-Kayıkçı, Elisa Kämmer, Lennart Hilbert   +2 more
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source