Results 161 to 170 of about 2,730,472 (338)
Advanced Biology, EarlyView.The study reveals that RRP9 is abnormally highly expressed in ESCC tissues and is closely associated with poor prognosis in patients. Furthermore, it is found that RRP9 promotes ESCC progression through enhancing the E2F1‐mediated transcriptional regulation of CDK1.
Gang He +14 more
wiley +1 more source
Loss of Stat3 in Prx1+ Progenitors Impairs Molar Root Development
Advanced Biology, EarlyView.Stat3 critically regulates mandibular first molar and alveolar bone morphogenesis. Conditional ablation of Stat3 disrupts the osteogenic capacity of Prx1+ mesenchymal progenitors, as evidenced across in vivo and in vitro models. Abstract Signal Transducer and Activator of Transcription 3 (Stat3) acts as a central transcriptional modulator coordinating ...
Xin Feng +10 more
wiley +1 more source
Transcriptional Repression of Tumor Suppressor CDC73, Encoding an RNA Polymerase II Interactor, by Wilms Tumor 1 Protein (WT1) Promotes Cell Proliferation [PDF]
, 2013 Mohammad Iqbal Rather +3 more
openalex +1 more source
Advanced Biology, EarlyView.This study highlights how cervical carcinoma progression is shaped by immune–tumor interactions within the TME. M2‐TAM infiltration, regulated through STAT3/NF‐κB and linked to CXCL12–CXCR4, promotes immune suppression, angiogenesis, and poor survival.
George A. Lira +11 more
wiley +1 more source
MicroRNA genes are transcribed by RNA polymerase II
EMBO Journal, 2004 Yoontae Lee +6 more
semanticscholar +1 more source
Engineering the Link: From Genome Interaction Maps to Functional Insight
Advanced Biology, EarlyView.Advances in chromosome conformation capture have revealed the genome's 3D organization, yet its causal impact on gene regulation remains elusive. This review highlights emerging genome‐engineering tools ‐ zinc fingers, TALEs, and CRISPR‐Cas9 ‐ that enable targeted manipulation of chromatin loops to dissect structure–function relationships. It discusses
Frido Petersen +5 more
wiley +1 more source
Versatile Cell Penetrating Peptide for Multimodal CRISPR Gene Editing in Primary Stem Cells
Advanced Functional Materials, EarlyView.CRISPR machinery in diverse molecular formats (DNA, RNA, and ribonucleic protein) is complexed into nanoparticles with the cell‐friendly arginine‐alanine‐leucine‐alanine (RALA) cell‐penetrating peptide. Nanoparticles are delivered to primary mesenchymal stem cells ex vivo or locally in vivo to facilitate multimodal CRISPR gene editing. This RALA‐CRISPR
Joshua P. Graham +9 more
wiley +1 more source
RNA polymerase promotes splicing, prevents degradation. [PDF]
PLoS Biology, 2006 Richard Robinson
doaj +1 more source