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The Mediator of RNA polymerase II
Chromosoma, 2005Mediator (TRAP/ARC/PC2) is a large (22-28 subunit) protein complex that binds RNA polymerase II and controls transcription from class II genes. The evolutionarily conserved core of Mediator is found in all eukaryotes. It binds RNA polymerase II and is probably critical for basal transcription but it also mediates activation and repression of ...
Erik, Blazek +2 more
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2013
Structures of yeast RNA polymerase II, alone and in the act of transcription with associated DNA and RNA, have been determined to near-atomic resolution. The structures illuminate the basis for the fidelity of transcription, for translocation on the DNA template, and for release of the product RNA.
David A. Bushnell, Roger D. Kornberg
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Structures of yeast RNA polymerase II, alone and in the act of transcription with associated DNA and RNA, have been determined to near-atomic resolution. The structures illuminate the basis for the fidelity of transcription, for translocation on the DNA template, and for release of the product RNA.
David A. Bushnell, Roger D. Kornberg
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Advances in RNA polymerase II transcription
Current Biology, 1992Multiple protein factors are necessary to mediate transcription by RNA polymerase II. Recently, a number of advances have been made in our understanding of how general transcription factors collectively modulate basal transcription in the context of different promoter environments and how this process is activated and repressed by accessory components.
L, Zawel, D, Reinberg
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Promoter escape by RNA polymerase II
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2002Transcription of protein-coding genes is one of the most fundamental processes that underlies all life and is a primary mechanism of biological regulation. In eukaryotic cells, transcription depends on the formation of a complex at the promoter region of the gene that minimally includes RNA polymerase II and several auxiliary proteins known as the ...
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Transcription elongation by RNA polymerase II
Current Opinion in Genetics & Development, 2003The elongation of transcripts by RNA polymerase II (RNAPII) is subject to regulation and requires the services of a host of accessory proteins. Although the biochemical mechanisms underlying elongation and its regulation remain obscure, recent progress sets the stage for rapid advancement in our understanding of this phase of transcription.
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Activation of RNA polymerase II transcription
Current Opinion in Cell Biology, 1999Multiple alternative interactions between activators and co-activators stimulate transcription by RNA polymerase II. In the past two years, multiprotein co-activator complexes have been characterized and their subunits defined. TATA-box binding protein associated factor (TAF) subunits of yeast TFIID were found to be generally required for transcription
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Transcription by RNA Polymerase II
1984Gene expression in eukaryotic cells is often regulated at the level of transcription of the gene (see Darnell, 1982). In order to understand viral growth, the response of cells to external stimuli, and the processes of differentiation and development, it is of importance to understand what controls the initiation of transcription at a gene.
Ulla Hansen, Phillip A. Sharp
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