Results 51 to 60 of about 821,958 (335)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Mechanistic insights into the transcriptional arrest in the presence of Double Strand Breaks [PDF]

, 2014
Double-strand breaks (DSBs) occur frequently in the genome during genome replication or by DNA damaging agents. DNA lesions affect fundamental DNA-dependent nuclear processes, such as replication and transcription.
Bonhomme, Celine, Chen, David, Eick, Dirk, Furst, Audrey, Pankotai, Tibor, Soutoglou, Evi, Sumara, Isabella   +6 more
core   +2 more sources

Sequential RNA polymerase II activation drives human hematopoiesis

Cell Reports
Summary: Promoter-proximal pausing of RNA polymerase II (Pol II) primes genes for rapid activation, yet how Pol II dynamics are temporally organized in adult stem cells to enable fast and flexible responses to environmental cues remain unknown.
Derek H. Janssens, Christine A. Codomo, Dominik J. Otto, Lev Silberstein, Kami Ahmad, Steve Henikoff   +5 more
doaj   +1 more source

A 212-nt long RNA structure in the Tobacco necrosis virus-D RNA genome is resistant to Xrn degradation [PDF]

, 2019
Plus-strand RNA viruses can accumulate viral RNA degradation products during infections. Some of these decay intermediates are generated by the cytosolic 5′-to-3′ exoribonuclease Xrn1 (mammals and yeast) or Xrn4 (plants) and are formed when the enzyme ...
Chaminda, Gunawardene D., Newburn, Laura R., White, K. Andrew   +2 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Unphosphorylated SR-like protein Npl3 stimulates RNA polymerase II elongation.

PLoS ONE, 2008
The production of a functional mRNA is regulated at every step of transcription. An area not well-understood is the transition of RNA polymerase II from elongation to termination. The S.
Jessica L Dermody, Jonathan M Dreyfuss, Judit Villén, Babatunde Ogundipe, Steven P Gygi, Peter J Park, Alfred S Ponticelli, Claire L Moore, Stephen Buratowski, Miriam E Bucheli   +9 more
doaj   +1 more source

The RNA Polymerase II Core Promoter in Drosophila. [PDF]

, 2019
Transcription by RNA polymerase II initiates at the core promoter, which is sometimes referred to as the "gateway to transcription." Here, we describe the properties of the RNA polymerase II core promoter in Drosophila The core promoter is at a strategic
Kadonaga, James T, Kassavetis, George A, Vo Ngoc, Long   +2 more
core   +1 more source

A Movie of RNA Polymerase II Transcription [PDF]

Cell, 2012
We provide here a molecular movie that captures key aspects of RNA polymerase II initiation and elongation. To create the movie, we combined structural snapshots of the initiation-elongation transition and of elongation, including nucleotide addition, translocation, pausing, proofreading, backtracking, arrest, reactivation, and inhibition.
Cheung, A.C.M., Cramer, P.
openaire   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Transcription Factor Binding to Replicated DNA

Cell Reports, 2020
Summary: Genome replication perturbs the DNA regulatory environment by displacing DNA-bound proteins, replacing nucleosomes, and introducing dosage imbalance between regions replicating at different S-phase stages.
Raz Bar-Ziv, Sagie Brodsky, Michal Chapal, Naama Barkai   +3 more
doaj   +1 more source