Results 251 to 260 of about 1,148,349 (307)

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Diverse stresses differentially regulate rRNA biogenesis and mRNA translation. [PDF]

Nucleic Acids Res
Aldrich A, Thomas R, Blower M, Lyons SM.
europepmc   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Japanese encephalitis virus hijacks the host purine biosynthetic network to promote viral replication in neurons. [PDF]

PLoS Pathog
Gu J, Fan C, Xiang S, Yang L, Liu J, Si Y, Zhu B, Sun Y, Ding C, Cao S, Ye J.   +10 more
europepmc   +1 more source

Presence and function of small RNAs during plant reproduction. [PDF]

RNA Biol
Yang AS, Tang AM, Gehring M.
europepmc   +1 more source

The Hidden Layer of MicroRNA Regulation in Gynecologic Cancers: IsomiRs, Arm Switching, and RNA Epitranscriptomic Modifications. [PDF]

Int J Mol Sci
Pérez-Navarro Y, López-Camarillo C, Flores-García LC, Alvarez-Sánchez ME, Campoy Ramírez A, Salinas-Vera YM.   +5 more
europepmc   +1 more source

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SPLICING OF MESSENGER RNA PRECURSORS

Annual Review of Biochemistry, 1986
Maria Magdalena Konarska, Richard A Padgett, Phillip Sharp   +2 more
exaly   +4 more sources

Ribosomal RNA precursors in plants

Journal of Molecular Biology, 1970
Abstract A high molecular weight, rapidly-labelled ribosomal RNA precursor in the pearoot tip and in artichoke-tuber tissue is described. It has a molecular weight, determined by polyacrylamide-gel electrophoresis, of about 2.3 × 10 6 daltons. The pea precursor RNA consists of two components which can just be distinguished by gel electrophoresis ...
M E, Rogers, U E, Loening, R S, Fraser
openaire   +2 more sources