Results 61 to 70 of about 310,443 (357)
Prebiotic precursors of the primordial RNA world in space: Detection of NH$_{2}$OH [PDF]
, 2020 One of the proposed scenarios for the origin of life is the primordial RNA world, which considers that RNA molecules were likely responsible for the storage of genetic information and the catalysis of biochemical reactions in primitive cells, before the advent of proteins and DNA. In the last decade, experiments in the field of prebiotic chemistry have
arxiv +1 more source
Precursors of the RNA-world in space: Detection of ($Z$)-1,2-ethenediol in the interstellar medium, a key intermediate in sugar formation [PDF]
, 2022 We present the first detection of ($Z$)-1,2-ethenediol, (CHOH)$_2$, the enol form of glycolaldehyde, in the interstellar medium towards the G+0.693-0.027 molecular cloud located in the Galactic Center. We have derived a column density of (1.8$\pm$0.1)$\times$10$^{13}$ cm$^{-2}$, which translates into a molecular abundance with respect to molecular ...
arxiv +1 more source
eLife, 2022 In plants, selfish genetic elements, including retrotransposons and DNA viruses, are transcriptionally silenced by RNA-directed DNA methylation. Guiding the process are short interfering RNAs (siRNAs) cut by DICER-LIKE 3 (DCL3) from double-stranded ...
Andrew Loffer +5 more
doaj +1 more source
Hydrogen peroxide thermochemical oscillator as driver for primordial RNA replication [PDF]
, 2014 This paper presents and tests a previously unrecognised mechanism for driving a replicating molecular system on the prebiotic earth. It is proposed that cell-free RNA replication in the primordial soup may have been driven by self-sustained oscillatory thermochemical reactions.
arxiv +1 more source
Joint optimization of replication potential and information storage set the letter size of primordial genetic alphabet [PDF]
arXiv, 2021 The simplest possible informational heteropolymer requires only a two-letter alphabet to be able to store information. The evolutionary choice of four monomers in the informational biomolecules RNA/DNA or their progenitors is intriguing, given the inherent difficulties in the simultaneous and localized prebiotic synthesis of all four monomers of ...
arxiv
Stability and Precursor Relationships of Virus RNA
Journal of General Virology, 1972 Summary Pulse-chase experiments with [3H]-uridine were performed with glucosamine-treated chick cells infected by RNA viruses. It was established that in cells infected by fowl plague virus both virus RNA and the RNA with the complementary base sequence were metabolically stable.
G. Kaluza +2 more
openaire +3 more sources
ADAR enzyme and miRNA story: A nucleotide that can make the difference [PDF]
, 2013 Adenosine deaminase acting on RNA (ADAR) enzymes convert adenosine (A) to inosine (I) in double-stranded (ds) RNAs. Since Inosine is read as Guanosine, the biological consequence of ADAR enzyme activity is an A/G conversion within RNA molecules.
Alisi, A +5 more
core +2 more sources
Acta Societatis Botanicorum Poloniae, 2014 Grains of winter rye harvested in 1976, 1978, 1982 and 1984 were studied. Free and membrane-bound polyribosomes were isolated from embryos of imbibing and germinating grains.
Kazimierz Zalewski
doaj +1 more source
Homochirality: a prerequisite or consequence of life? [PDF]
Prebiotic Chemistry and the Origin of Life, edited by Neubeck,
Anna; McMahon, Sean. ISBN: 978-3-030-81039-9. Cham: Springer International
Publishing, 2021, pp. 87-115, 2020 Many of the building blocks of life such as amino acids and nucleotides are chiral, i.e., different from their mirror image. Contemporary life selects and synthesizes only one of two possible handednesses. In an abiotic environment, however, there are usually equally many left- and right-handed molecules.
arxiv +1 more source
Gene induction during differentiation of human monocytes into dendritic cells: an integrated study at the RNA and protein levels [PDF]
, 2001 Changes in gene expression occurring during differentiation of human monocytes into dendritic cells were studied at the RNA and protein levels. These studies showed the induction of several gene classes corresponding to various biological functions ...
Angénieux, C. +9 more
core +3 more sources