Results 41 to 50 of about 1,148,349 (307)

Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses:Implications for virus evolution and host persistence [PDF]

, 2004
Discrete RNA secondary and higher-order structures, typically local in extent, play a fundamental role in RNA virus replication. Using new bioinformatics analysis methods, we have identified genome-scale ordered RNA structure (GORS) in many genera and ...
Evans, David J, Simmonds, Peter, Tuplin, Andrew, Tuplin, A, Evans, DJ, Simmonds, P   +5 more
core   +1 more source

The Genesis of Human Breast Cancer: Histological, Histochemical and Cariometric Studies: Proposition on the Genesis of Cancer

Revista Brasileira de Cancerologia, 2023
1. Câncer arises gradually, preceded by histological, histochemical and cariometric (tetraploidism) or hyperdiploidism pictures which may be called morphological precursors of câncer. 2.
Aurélio Monteiro
doaj   +1 more source

RNA-binding protein immunoprecipitation as a tool to investigate plant miRNA processing interference by regulatory proteins of diverse origin

Plant Methods, 2018
Background Due to the nature of viral RNA genomes, RNA viruses depend on many RNA-binding proteins (RBP) of viral and host origin for replication, dissemination and evasion of host RNA degradation pathways. Some viruses interfere with the microRNA (miRNA)
F. E. Marmisolle, M. L. García, C. A. Reyes   +2 more
doaj   +1 more source

Differential polyadenylation of ribosomal RNA during post-transcriptional processing in Leishmania. [PDF]

, 2005
The protozoan parasite Leishmania belongs to the most ancient eukaryotic lineages and this is reflected in several distinctive biological features, such as eukaryotic polycistronic transcription and RNA trans-splicing.
Laurent, T., Chappuis, F., Llanos-Cuentas, A., Llanos-Cuentas, A, V. YARDLEY, F. CHAPPUIS, Laurent, T, T. LAURENT, Dujardin, J. C., Vandesompele, J, J.-C. DUJARDIN, DE DONCKER, S, S. RIJAL, Decuypere, S., S. DECUYPERE, Yardley, V, De Donckeri, S, Vandesompele, Jo, Rijal, S., J. AREVALO, Vandesompele, J., S. DE DONCKER, J. VANDESOMPELE, Yardley, V., Chappuis, F, Arevalo, J., Arevalo, J, Rijal, S, De Doncker, S., A. LLANOS-CUENTAS, Dujardin, JC, Decuypere, S   +31 more
core   +1 more source

Hfq and RNase R Mediate rRNA Processing and Degradation in a Novel RNA Quality Control Process

mBio, 2020
RNA quality control pathways are critical for cell survival. Here, we describe a new surveillance process involved in the degradation of highly structured and stable ribosomal RNAs.
Ricardo F. dos Santos, José M. Andrade, Joana Pissarra, Murray P. Deutscher, Cecília M. Arraiano   +4 more
doaj   +1 more source

Structural determinants of Arabidopsis thaliana Hyponastic leaves 1 function in vivo. [PDF]

PLoS ONE, 2014
MicroRNAs have turned out to be important regulators of gene expression. These molecules originate from longer transcripts that are processed by ribonuclease III (RNAse III) enzymes. Dicer proteins are essential RNAse III enzymes that are involved in the
Paula Burdisso, Fernando Milia, Arnaldo L Schapire, Nicolás G Bologna, Javier F Palatnik, Rodolfo M Rasia   +5 more
doaj   +1 more source

Sequential packaging of RNA genomic segments during the assembly of Bluetongue virus. [PDF]

, 2014
Bluetongue virus (BTV), a member of the Orbivirus genus within the Reoviridae family, has a genome of 10 double-stranded RNA segments, with three distinct size classes.
Roy, Polly, Sung, Po-Yu, Po-yu Sung, Polly Roy   +3 more
core   +1 more source

An improved in vivo tethering assay with single molecule FISH reveals that a nematode Nanos enhances reporter expression and mRNA stability

, 2021
Robust methods are critical for testing the in vivo regulatory mechanism of RNA binding proteins. Here we report improvement of a protein–mRNA tethering assay to probe the function of an RNA binding protein in its natural context within the C.
Kimble, Judith, Lynch, Tina R., Aoki, Scott T., Doenier, Jonathan   +3 more
core   +1 more source

Secondary structure RNA elements control the cleavage activity of DICER

Nature Communications, 2022
MicroRNA precursors are cleaved by DICER to generate mature microRNAs in the cytoplasm. Here the authors employ high-throughput analysis of DICER cleavage activity and identify RNA secondary elements in precursor miRNAs and shRNAs, including a single ...
Trung Duc Nguyen, Tam Anh Trinh, Sheng Bao, Tuan Anh Nguyen   +3 more
doaj   +1 more source

Mutations in the U5 snRNA result in altered splicing of subsets of pre-mRNAs and reduced stability of Prp8 [PDF]

, 2009
The U5 snRNA loop 1 aligns the 5' and 3' exons for ligation during the second step of pre-mRNA splicing. U5 is intimately associated with Prp8, which mediates pre-mRNA repositioning within the catalytic core of the spliceosome and interacts directly with
David Barrass, J., Kershaw, Christopher J., O'Keefe, Raymond T., Barrass, J. David, Beggs, Jean D., O'Keefe, Raymond T.; id_orcid   +5 more
core   +1 more source