Results 51 to 60 of about 2,192,206 (343)

Secondary structure RNA elements control the cleavage activity of DICER

Nature Communications, 2022
MicroRNA precursors are cleaved by DICER to generate mature microRNAs in the cytoplasm. Here the authors employ high-throughput analysis of DICER cleavage activity and identify RNA secondary elements in precursor miRNAs and shRNAs, including a single ...
Trung Duc Nguyen, Tam Anh Trinh, Sheng Bao, Tuan Anh Nguyen   +3 more
doaj   +1 more source

Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein [PDF]

, 2011
23.04.14 KB.
Stephen Curry, Stephen J. Smerdon, Tam T. T. Bui, Kelly, Geoff, Drake, AF, Simon Pennell, Kotik-Kogan, O, Martino, Luigi, Pennell, Simon, Smerdon, Stephen J., Alex F. Drake, Conte, MR, Geoff Kelly, Kotik-Kogan, Olga, Bui, TTT, Smerdon, SJ, Bui, Tam T. T.; id_orcid, Martino, L, Pennell, S, Curry, Stephen, Conte, Maria R.; id_orcid, Kelly, G, Curry, S, Olga Kotik-Kogan, Drake, Alex F., Luigi Martino, Maria R. Conte   +26 more
core   +1 more source

3 '-processing of yeast tRNA(Trp) precedes 5 '-processing [PDF]

, 2003
Previous analyses of eukaryotic pre-tRNAs processing have reported that 5'-cleavage by RNase P precedes 3'-maturation. Here we report that in contrast to all other yeast tRNAs analyzed to date, tRNA(Trp) undergoes 3'-maturation prior to 5'-cleavage ...
Tollervey, D, Kufel, J
core   +1 more source

The metabolism of aged seeds. The free and membrane-bound polyribosomes of germinating rye grains of different ages

Acta Societatis Botanicorum Poloniae, 2014
Grains of winter rye harvested in 1976, 1978, 1982 and 1984 were studied. Free and membrane-bound polyribosomes were isolated from embryos of imbibing and germinating grains.
Kazimierz Zalewski
doaj   +1 more source

Integrating transcriptome and metabolome to identify key genes regulating important muscular flavour precursors in sheep

Animal, 2022
Flavour precursors are the basis of meat flavour, and their metabolism is regulated by a variety of enzymes. Thus, it is of great significance to identify the key genes related to meat flavour precursors.
X.Y. Zhang, Z.H. Yuan, F.D. Li, X.P. Yue
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The RNA helicases AtMTR4 and HEN2 target specific subsets of nuclear transcripts for degradation by the nuclear exosome in Arabidopsis thaliana.

PLoS Genetics, 2014
The RNA exosome is the major 3'-5' RNA degradation machine of eukaryotic cells and participates in processing, surveillance and turnover of both nuclear and cytoplasmic RNA.
Heike Lange, Hélène Zuber, François M Sement, Johana Chicher, Lauriane Kuhn, Philippe Hammann, Véronique Brunaud, Caroline Bérard, Nathalie Bouteiller, Sandrine Balzergue, Sébastien Aubourg, Marie-Laure Martin-Magniette, Hervé Vaucheret, Dominique Gagliardi   +13 more
doaj   +1 more source

Correlation between circulating innate lymphoid cell precursors and thymic function

iScience, 2022
Summary: The thymus has a high capacity to support the differentiation of ILCs, especially when E protein transcription factors are ablated. Whether it contributes to the homeostasis of ILC pools in tissues is not clear.
Sandra Bajana, Aneta Pankow, Kaili Liu, Martyna Michniowska, Joseph F. Urban, Jr., Wei R. Chen, Xiao-Hong Sun   +6 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source