Results 61 to 70 of about 2,192,206 (343)
Identification of General and Heart-Specific miRNAs in Sheep (Ovis aries).
PLoS ONE, 2015 MicroRNAs (miRNAs or miRs) are small regulatory RNAs crucial for modulation of signaling pathways in multiple organs. While the link between miRNAs and heart disease has grown more readily apparent over the past three years, these data are primarily ...
Alessandro Laganà +6 more
doaj +1 more source
LIN28 Zinc Knuckle Domain Is Required and Sufficient to Induce let-7 Oligouridylation
Cell Reports, 2017 LIN28 is an RNA binding protein that plays crucial roles in pluripotency, glucose metabolism, tissue regeneration, and tumorigenesis. LIN28 binds to the let-7 primary and precursor microRNAs through bipartite recognition and induces degradation of let-7 ...
Longfei Wang +7 more
doaj +1 more source
eLife, 2022 The genesis of broad neuronal classes from multipotential neural progenitor cells has been extensively studied, but less is known about the diversification of a single neuronal class into multiple types.
Karthik Shekhar +4 more
doaj +1 more source
Precursors to small molecular weight RNA components [PDF]
FEBS Letters, 1975 Metabolically long-lived RNA components such as tRNA and rRNA are formed from unstable larger precursors [ 1,2] . Baby Hamster Kidney cells (BHK-2 1 cells) contain four small mol. wt RNA components (sm RNA) with a metabolic half-life of 5-7 days [3] . The size of these components (D, C, A, and L) was determined to be from 145 to 235 nucleotides based ...
Frederiksen, Sune, Hellung-Larsen, Per
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
The RNA Polymerase II-associated factor 1 complex represses small-RNA-mediated heterochromatin formation and gene silencing [PDF]
, 2015 RNAi interference (RNAi) is a highly conserved regulatory mechanism employed by almost all Eukaryotes. With RNAi organisms can modulate the expression of endogenous genes and protect the integrity and identity of their genomes.
Kowalik, Katarzyna Maria
core +1 more source
The H/ACA complex disrupts triplex in hTR precursor to permit processing by RRP6 and PARN
Nature Communications, 2018 Telomerase RNA (hTR) is transcribed as a 3′-extended precursor. Here the authors examine the processing of hTR precursors of various lengths and show that processing occurs in distinct steps involving different nucleases PARN and RRP6.
Chi-Kang Tseng +3 more
doaj +1 more source
Primary and secondary siRNAs in geminivirus-induced gene silencing. [PDF]
PLoS Pathogens, 2012 In plants, RNA silencing-based antiviral defense is mediated by Dicer-like (DCL) proteins producing short interfering (si)RNAs. In Arabidopsis infected with the bipartite circular DNA geminivirus Cabbage leaf curl virus (CaLCuV), four distinct DCLs ...
Michael Aregger +10 more
doaj +1 more source
MapToCleave: High-throughput profiling of microRNA biogenesis in living cells
Cell Reports, 2021 Summary: Previous large-scale studies have uncovered many features that determine the processing of microRNA (miRNA) precursors; however, they have been conducted in vitro.
Wenjing Kang +10 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source