Results 131 to 140 of about 203,837 (307)

RBPs in Hematopoietic Stem Cell Maintenance and Leukemia Initiation: Critical Gaps

Archives of Advances in Biosciences
Context RNA-binding proteins (RBPs) are key regulators of post-transcriptional gene expression and play essential roles in hematopoietic stem cell (HSC) function.
Muhammad Haris Baig
doaj   +1 more source

Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 nuclear bodies [PDF]

, 2009
Background: Active pre-mRNA splicing occurs co-transcriptionally, and takes place throughout the nucleoplasm of eukaryotic cells. Splicing decisions are controlled by networks of nuclear RNA-binding proteins and their target sequences, sometimes in ...
Rajan, P., Heiner, M., Leung, Hing, Dalgliesh, C., Bindereif, A, David J Elliott, Dalgliesh, C, Craig N Robson, Dalgliesh Caroline, Elliott, David, Kaveh Emami, Bindereif, A., Heiner Monika, Emami, K, Clark, E.L., Hing Y Leung, Elliott, D.J., Elliott, DJ, Rajan, Prabhakar, Leung Hing Y, Heiner, M, Bourgeois, C.F., Rajan, P, Prabhakar Rajan, Emami, K., Leung, H.Y., Elliott David J, Stevenin James, Stevenin, J., Clark Emma L, Emami, Kaveh, Bindereif, Albrecht, Bourgeois, CF, Bindereif Albrecht, Cyril F Bourgeois, Robson, C.N., Bourgeois, Cyril F, Prabhakar Rajan, Albrecht Bindereif, Heiner, Monika, Caroline Dalgliesh, Robson Craig N, Robson, Craig, Emma L Clark, Clark, EL, Dalgliesh, Caroline, Stevenin, J, Leung, HY, Stevenin, James, Robson, CN, Rajan Prabhakar, Bourgeois Cyril F, Emami Kaveh, Monika Heiner, James Stevenin, Clark, Emma   +55 more
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Staphylococcus aureus Small Colony Variants (SCVs): A Road Map for the Metabolic Pathways Involved in Persistent Infections

Frontiers in Cellular and Infection Microbiology, 2014
Persistent and relapsing infections, despite apparently adequate antibiotic therapy, occur frequently with many pathogens, but it is an especially prominent problem with Staphylococcus aureus infections. For the purposes of this review, persistence will
Richard Allan Proctor, Andre eKriegeskorte, Barbara eKahl, Karsten eBecker, Bettina eLöffler, Georg ePeters   +5 more
doaj   +1 more source

Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development [PDF]

, 2010
A universal feature of metazoan sexual development is the generation of oocyte P granules that withhold certain mRNA species from translation to provide coding potential for proteins during early post-fertilization development.
Lasonder Edwin, Franke-Fayard, Blandine M. D., Edwin Lasonder, Carret Céline K., Waters Andrew P., Lasonder, Edwin, Gunnar R Mair, Franke-Fayard Blandine M. D., Roeland W Dirks, Waters, A.P., Wiegant, J.C., Céline K Carret, Mair, G.R., Dimopoulos George, Lindsey S Garver, Mair Gunnar R., Wiegant, G., Janse, Chris J., Franke-Fayard, B.M.D., Carret, C.K., Dirks Roeland W., Mair, Gunnar R., Blandine M D Franke-Fayard, Dimopoulos, George, Wiegant, J.C.A.G., Lasonder, E., Dimopoulos, G., Janse, C.J., Joop, C.A., Wiegant, Joop C. A. G., Carret, Céline K., Waters, A., George Dimopoulos, Dirks, Roeland W., Waters, Andrew P., Garver, Lindsey S., Janse Chris J., Chris J Janse, Garver Lindsey S., Joop C A G Wiegant, Garver, L.S., Wiegant Joop C. A. G., Dirks, R.W., Franke-Fayard, B., Andrew P Waters   +44 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

RNA-binding proteins as targets for pain therapeutics

Neurobiology of Pain, 2018
RNA-protein interactions permeate biology. Transcription, translation, processing, and mRNA decay all hinge on widespread use of regulatory information decoded by RNA-binding proteins.
June Bryan de la Peña, Zachary T. Campbell   +1 more
doaj   +1 more source

Computational discovery of animal small RNA genes and targets [PDF]

, 2007
Though recently discovered, small RNAs appear to play a wealth of regulatory roles, being involved in degradation of target mRNAs, translation silencing of target genes, chromatin remodeling and transposon silencing.
Gaidatzis, Dimosthenis
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Post-translational Modifications And Rna-binding Proteins

, 2017
RNA-binding proteins affect cellular metabolic programs through development and in response to cellular stimuli. Though much work has been done to elucidate the roles of a handful of RNA-binding proteins and their effect on RNA metabolism, the progress ...
Mario H.; Massirer, Michael T.; Bengtson, Lovci, Katlin B.   +3 more
core   +1 more source