Results 131 to 140 of about 1,048,276 (285)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Subcellular partitioning of MRP RNA assessed by ultrastructural and biochemical analysis. [PDF]

, 1994
A small RNA encoded within the nucleus is an essential subunit of a RNA processing endonuclease (RNase MRP) hypothesized to generate primers for mitochondrial DNA replication from the heavy strand origin of replication.
Gonzalez, M, Hagler, HK, Li, K, Parsons, WJ, Richardson, JA, Smagula, CS, Williams, RS   +6 more
core  

Understanding the errors of SHAPE-directed RNA structure modeling

, 2011
Single-nucleotide-resolution chemical mapping for structured RNA is being rapidly advanced by new chemistries, faster readouts, and coupling to computational algorithms.
Aviran S., Brunel C., Butler E. B., Byrne R. T., Cate J. H., Christopher C. VanLang, Collins K., Correll C. C., Cruz J. A., Darty K., Das R., Das R., Deigan K. E., Efron B., Efron B., Felsenstein J., Gesteland R. F., Hickey D. R., Hofacker I. L., Kladwang W., Kladwang W., Kulshina N., Kwon M., Lemay J. F., Leontis N. B., Levitt M., Mandal M., Mandal M., Mathews D. H., Mathews D. H., Mills D. R., Mitra S., Mortimer S. A., Noller H. F., Pablo Cordero, Panning B., Pedersen J. S., Regulski E. E., Rhiju Das, Russell R., Russell R., Serganov A., Smith K. D., Staley J. P., Sudarsan N., Sussman J. L., Takamoto K., Vasa S. M., Watts J. M., Wilkinson K. A., Wilkinson K. A., Winkler W. C., Wipapat Kladwang, Yoon S.   +53 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Computational identification and analysis of noncoding RNAs - Unearthing the buried treasures in the genome [PDF]

, 2007
The central dogma of molecular biology states that the genetic information flows from DNA to RNA to protein. This dogma has exerted a substantial influence on our understanding of the genetic activities in the cells.
Vaidyanathan, P. P., Yoon, Byung-Jun
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Expression of the Thyroid Hormone Receptor Gene, erbAα, in B Lymphocytes: Alternative mRNA Processing is Independent of Differentiation but Correlates with Antisense RNA Levels [PDF]

, 1997
The erbAα gene encodes two α-thyroid hormone receptor isoforms, TRα1 and TRα2, which arise from alternatively processed mRNAs, erbAα1 (α1) and erb α2 (α2).
Hastings, Michelle Laura, Martincic, Kathlee, Milcarek, Christine, Munroe, Stephen H., Peterson, Martha L.   +4 more
core   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Bistability of an In Vitro Synthetic Autoregulatory Switch [PDF]

, 2011
The construction of synthetic biochemical circuits is an essential step for developing quantitative understanding of information processing in natural organisms.
Kim, Jongmin, Subsoontorn, Pakpoom, Winfree, Erik   +2 more
core