Results 21 to 30 of about 1,674,122 (352)
A Robust and Precise ConvNet for Small Non-Coding RNA Classification (RPC-snRC)
IEEE Access, 2021 Small non-coding RNAs (ncRNAs) are attracting increasing attention as they are now considered potentially valuable resources in the development of new drugs intended to cure several human diseases.
Muhammad Nabeel Asim +5 more
doaj +1 more source
RNA cytosine methylation analysis by bisulfite sequencing [PDF]
Nucleic Acids Research, 2008 Covalent modifications of nucleic acids play an important role in regulating their functions. Among these modifications, (cytosine-5) DNA methylation is best known for its role in the epigenetic regulation of gene expression. Post-transcriptional RNA modification is a characteristic feature of noncoding RNAs, and has been described for rRNAs, tRNAs and
Tim Pollex +3 more
openaire +3 more sources
Small RNA sequencing profiles of mir-181 and mir-221, the most relevant microRNAs in acute myeloid leukemia [PDF]
The Korean Journal of Internal Medicine, 2019 Background/Aims To evaluate and select microRNAs relevant to acute myeloid leukemia (AML) pathogenesis, we analyzed differential microRNA expression by quantitative small RNA next-generation sequencing using duplicate marrow samples from individual AML ...
Yun-Gyoo Lee +5 more
doaj +1 more source
ANALYSIS OF LARGE-SCALE SEQUENCING OF SMALL RNAS [PDF]
Biocomputing 2008, 2007 The advent of large-scale sequencing has opened up new areas of research, such as the study of Piwi-interacting small RNAs (piRNAs). piRNAs are longer than miRNAs, close to 30 nucleotides in length, involved in various functions, such as the suppression of transposons in germline. Since a large number of them (many tens of thousands) are generated from
Olson, A. J. +4 more
openaire +4 more sources
TT2NE: A novel algorithm to predict RNA secondary structures with pseudoknots [PDF]
, 2010 We present TT2NE, a new algorithm to predict RNA secondary structures with pseudoknots. The method is based on a classification of RNA structures according to their topological genus.
Bailor +29 more
core +4 more sources
Primary structure and functional expression of a high voltage activated calcium channel from rabbit lung [PDF]
, 1990 The complete amino acid sequence of the receptor for organic calcium channel blockers (CaCB) from rabbit lung has been deduced by cloning and sequence analysis of the cDNA.
Bean +24 more
core +2 more sources
Recent advances in RNA sequence analysis [PDF]
F1000 Biology Reports, 2010 The latest high-throughput DNA sequencing technology can now be applied on a large scale to capture the complete set of mRNA transcripts in a cell, using a technique called RNA-seq. Although RNA-seq is only 2 years old, it has rapidly swept through the field of genomics, and it is now being used to analyze the transcriptomes of organisms ranging from ...
openaire +3 more sources
Global analysis of RNA cleavage by 5′-hydroxyl RNA sequencing [PDF]
Nucleic Acids Research, 2015 RNA cleavage by some endoribonucleases and self-cleaving ribozymes produces RNA fragments with 5'-hydroxyl (5'-OH) and 2',3'-cyclic phosphate termini. To identify 5'-OH RNA fragments produced by these cleavage events, we exploited the unique ligation mechanism of Escherichia coli RtcB RNA ligase to attach an oligonucleotide linker to RNAs with 5'-OH ...
Kerri York +2 more
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Quantifying the relationship between sequence and three-dimensional structure conservation in RNA
BMC Bioinformatics, 2010 Background In recent years, the number of available RNA structures has rapidly grown reflecting the increased interest on RNA biology. Similarly to the studies carried out two decades ago for proteins, which gave the fundamental grounds for developing ...
Capriotti Emidio, Marti-Renom Marc A
doaj +1 more source
RNA Sequencing Data: Hitchhiker's Guide to Expression Analysis [PDF]
Annual Review of Biomedical Data Science, 2018 Gene expression is the fundamental level at which the results of various genetic and regulatory programs are observable. The measurement of transcriptome-wide gene expression has convincingly switched from microarrays to sequencing in a matter of years.
Mark D. Robinson +8 more
openaire +3 more sources