Results 21 to 30 of about 2,532,976 (299)
Deciphering the RRM-RNA recognition code: A computational analysis.
PLoS Computational Biology, 2023 RNA recognition motifs (RRM) are the most prevalent class of RNA binding domains in eucaryotes. Their RNA binding preferences have been investigated for almost two decades, and even though some RRM domains are now very well described, their RNA ...
Joel Roca-Martínez +3 more
doaj +1 more source
Development of strategies for SNP detection in RNA-seq data: application to lymphoblastoid cell lines and evaluation using 1000 Genomes data. [PDF]
PLoS ONE, 2013 Next-generation RNA sequencing (RNA-seq) maps and analyzes transcriptomes and generates data on sequence variation in expressed genes. There are few reported studies on analysis strategies to maximize the yield of quality RNA-seq SNP data.
Emma M Quinn +7 more
doaj +1 more source
Informatics in Medicine Unlocked, 2021 RNA binding proteins are involved in many functions, though the majority of them are composed into small RNA binding domains. The S15/NS1 RNA binding domain is a ribosomal S15 and the non-structural NS1 protein. In this study, an attempt was made to find
S. Muthu Krishnan
doaj +1 more source
Structural Alignment and Covariation Analysis of RNA Sequences [PDF]
BIO-PROTOCOL, 2020 RNA molecules adopt defined structural conformations that are essential to exert their function. During the course of evolution, the structure of a given RNA can be maintained via compensatory base-pair changes that occur among covarying nucleotides in paired regions.
Nicolas Tourasse, Fabien Darfeuille
openaire +3 more sources
Circular RNA Expression Profiles in Nasopharyngeal Carcinoma by Sequence Analysis
Frontiers in Oncology, 2020 Circular RNAs (circRNAs), as a burgeoning sort of non-coding RNAs (ncRNAs), can regulate the expression of parental genes as miRNA sponges. This study was designed to explore the circRNA expression profile of nasopharyngeal carcinoma (NPC).
Jing Yang +7 more
doaj +1 more source
Analysis of Small RNA Sequencing Data in Plants [PDF]
, 2022 AbstractOver the past decades, next-generation sequencing (NGS) has been employed extensively for investigating the regulatory mechanisms of small RNAs. Several bioinformatics tools are available for aiding biologists to extract meaningful information from enormous amounts of data generated by NGS platforms.
Garg, V., Varshney, R.K.
openaire +3 more sources
Big Data Analytics in RNA-sequencing
Korean Journal of Clinical Laboratory Science, 2023 As next-generation sequencing has been developed and used widely, RNA-sequencing (RNA-seq) has rapidly emerged as the first choice of tools to validate global transcriptome profiling.
Sung-Hun WOO, Byung Chul JUNG
doaj +1 more source
An Rna Sequencing Analysis of Glaucoma Genesis in Mice
Artificial Intelligence, Soft Computing and Applications, 2022 Glaucoma is the leading cause of irreversible blindness in people over the age of 60, accounting for 6.6 to 8% of all blindness in 2010, but there is still much to be learned about the genetic origins of the eye disease. With the modern development of Next-Generation Sequencing (NGS) technologies, scientists are starting to learn more about the genetic
Sharma, Jai, Bhaskar, Vidhyacharan
openaire +2 more sources
PLoS ONE, 2015 Huntington’s Disease (HD) is a devastating neurodegenerative disorder that is caused by an expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene.
Adam T. Labadorf +11 more
semanticscholar +1 more source
Global analysis of RNA cleavage by 5′-hydroxyl RNA sequencing [PDF]
Nucleic Acids Research, 2015 RNA cleavage by some endoribonucleases and self-cleaving ribozymes produces RNA fragments with 5'-hydroxyl (5'-OH) and 2',3'-cyclic phosphate termini. To identify 5'-OH RNA fragments produced by these cleavage events, we exploited the unique ligation mechanism of Escherichia coli RtcB RNA ligase to attach an oligonucleotide linker to RNAs with 5'-OH ...
Peach, Sally E. +2 more
openaire +2 more sources