Results 71 to 80 of about 1,457,994 (304)

Virtual Environment for Next Generation Sequencing Analysis [PDF]

, 2012
Next Generation Sequencing technology, on the one hand, allows a more accurate analysis, and, on the other hand, increases the amount of data to process.
Abate, Francesco, Acquaviva, Andrea, Mossucca, L., Provenzano, R., Terzo, Olivier   +4 more
core  

FLASH: ultra-fast protocol to identify RNA-protein interactions in cells

, 2019
Determination of the in vivo binding sites of RNA-binding proteins (RBPs) is paramount to understanding their function and how they affect different aspects of gene regulation.
Akhtar, A., Aktas, T., Backofen, R., Ilik, I., Maticzka, D.   +4 more
core   +1 more source

Zipper plot : visualizing transcriptional activity of genomic regions [PDF]

, 2017
Background: Reconstructing transcript models from RNA-sequencing (RNA-seq) data and establishing these as independent transcriptional units can be a challenging task.
Avila Cobos, Francisco, Anckaert, Jasper, Volders, Pieter-Jan, Everaert, Celine, Rombaut, Dries, Vandesompele, Jo, De Preter, Katleen, Mestdagh, Pieter   +7 more
core   +2 more sources

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Compilation of small RNA sequences [PDF]

Nucleic Acids Research, 1994
This is an update containing small RNA sequences deposited in GenBank recently. Over four hundred small RNA sequences are available in this and earlier complications.
J, Gu, R, Reddy
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Next-generation sequencing of dsRNA is greatly improved by treatment with the inexpensive denaturing reagent DMSO. [PDF]

, 2019
dsRNA is the genetic material of important viruses and a key component of RNA interference-based immunity in eukaryotes. Previous studies have noted difficulties in determining the sequence of dsRNA molecules that have affected studies of immune function
Delwart, Eric, Díaz-Muñoz, Samuel L, Wilcox, Alexander H   +2 more
core  

Polymorphism identification and improved genome annotation of Brassica rapa through Deep RNA sequencing. [PDF]

, 2014
The mapping and functional analysis of quantitative traits in Brassica rapa can be greatly improved with the availability of physically positioned, gene-based genetic markers and accurate genome annotation.
Covington, Michael F, Devisetty, Upendra Kumar, Lekkala, Saradadevi, Maloof, Julin N, Tat, An V   +4 more
core   +1 more source

RNA-sequencing from single nuclei [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance One of the central goals of developmental biology and medicine is to ascertain the relationships between the genotype and phenotype of cells. Single-cell transcriptome analysis represents a powerful strategy to reach this goal.
Rashel V, Grindberg, Joyclyn L, Yee-Greenbaum, Michael J, McConnell, Mark, Novotny, Andy L, O'Shaughnessy, Georgina M, Lambert, Marcos J, Araúzo-Bravo, Jun, Lee, Max, Fishman, Gillian E, Robbins, Xiaoying, Lin, Pratap, Venepally, Jonathan H, Badger, David W, Galbraith, Fred H, Gage, Roger S, Lasken   +15 more
openaire   +2 more sources