Silencing viruses by RNA interference
Microbes and Infection, 2005 Post-transcriptional gene silencing (PTGS) makes possible new approaches for studying the various steps of the viral cycle. Plus-strand RNA viruses appear to be attractive targets for small interfering RNAs (siRNAs), as their genome functions as both mRNA and replication template. PTGS creates an alternative to classic reverse genetics for viruses with
Colbère-Garapin, Florence +4 more
openaire +4 more sources
RNA interference: more than a research tool in the vertebrates' adaptive immunity
Retrovirology, 2005 In recent years, RNA silencing, usage of small double stranded RNAs of ~21 – 25 base pairs to regulate gene expression, has emerged as a powerful research tool to dissect the role of unknown host cell factors in this 'post-genomic' era.
Mak Johnson
doaj +1 more source
Distinct Effects of p19 RNA Silencing Suppressor on Small RNA Mediated Pathways in Plants
PLoS Pathogens, 2016 RNA silencing is one of the main defense mechanisms employed by plants to fight viruses. In change, viruses have evolved silencing suppressor proteins to neutralize antiviral silencing.
Levente Kontra +9 more
semanticscholar +1 more source
RNA polymerase V-dependent small RNAs in Arabidopsis originate from small, intergenic loci including most SINE repeats. [PDF]
, 2012 In plants, heterochromatin is maintained by a small RNA-based gene silencing mechanism known as RNA-directed DNA methylation (RdDM). RdDM requires the non-redundant functions of two plant-specific DNA-dependent RNA polymerases (RNAP), RNAP IV and RNAP V.
Chen, Xuemei +7 more
core +2 more sources
Influence of viral genes on the cell-to-cell spread of RNA silencing [PDF]
The turnip crinkle virus-based vector TCV–GFPDCP had been devised previously to study cell-to-cell and long-distance spread of virus-induced RNA silencing.
Hong, Yiguo +3 more
core +1 more source
Acquisition of full-length viral helicase domains by insect retrotransposon-encoded polypeptides
Frontiers in Microbiology, 2015 Recent metagenomic studies in insects identified many sequences unexpectedly closely related to plant virus genes. Here we describe a new example of this kind, insect R1 LINEs with an additional C-terminal domain in their open reading frame 2.
Ekaterina eLazareva +4 more
doaj +1 more source
RNA-directed DNA methylation involves co-transcriptional small-RNA-guided slicing of polymerase V transcripts in Arabidopsis. [PDF]
, 2018 Small RNAs regulate chromatin modifications such as DNA methylation and gene silencing across eukaryotic genomes. In plants, RNA-directed DNA methylation (RdDM) requires 24-nucleotide small interfering RNAs (siRNAs) that bind to ARGONAUTE 4 (AGO4) and ...
Chory, Joanne +11 more
core +1 more source
Viruses, 2017 RNA silencing has an important role in defending against virus infection in plants. Plants with the deficiency of RNA silencing components often show enhanced susceptibility to viral infections.
Fangfang Li, Yaqin Wang, Xueping Zhou
doaj +1 more source
Reprogramming of RNA silencing triggered by cucumber mosaic virus infection in Arabidopsis
Genome Biology, 2021 Background RNA silencing has an important role mediating sequence-specific virus resistance in plants. The complex interaction of viruses with RNA silencing involves the loading of viral small interfering RNAs (vsiRNAs) into its host ARGONAUTE (AGO ...
Maria Luz Annacondia, German Martinez
doaj +1 more source
Role of RNA Interference (RNAi) in the Moss Physcomitrella patens [PDF]
, 2013 RNA interference (RNAi) is a mechanism that regulates genes by either transcriptional (TGS) or posttranscriptional gene silencing (PTGS), required for genome maintenance and proper development of an organism.
Arif, Muhammad Asif +2 more
core +3 more sources