Results 91 to 100 of about 160,310 (303)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Suppressors of RNA silencing encoded by geminiviruses and associated DNA satellites [PDF]

VirusDisease, 2018
In plants, RNA silencing provides a major line of defence against viruses. This antiviral immunity involves production of virus-derived small interfering RNAs (vsiRNAs) and results in specific silencing of viruses by vsiRNAs-guided effector complexes.
Rashmi Rishishwar, Indranil Dasgupta
openaire   +2 more sources

Root-Knot Nematode Parasitism Suppresses Host RNA Silencing

Molecular Plant-Microbe Interactions, 2017
Root-knot nematodes damage crops around the world by developing complex feeding sites from normal root cells of their hosts. The ability to initiate and maintain this feeding site (composed of individual “giant cells”) is essential to their parasitism ...
E. Walsh, J. M. Elmore, C. G. Taylor
doaj   +1 more source

Argonaute 2 drives miR-145-5p-dependent gene expression program in breast cancer cells [PDF]

, 2019
To perform their regulatory functions, microRNAs (miRNAs) must assemble with any of the four mammalian Argonaute (Ago) family of proteins, Ago1–4, into an effector complex known as the RNA-induced silencing complex (RISC).
Bellissimo, Teresa, Blandino, Giovanni, Calogero, Antonella, Cirenza, Mirko, De Angelis, Luciana, Di Martino, Giuseppe, Fatica, Alessandro, Fazi, Francesco, Fontemaggi, Giulia, Ganci, Federica, Masciarelli, Silvia, Petrozza, Vincenzo, Porta, Natale, Rosa, Paolo, Sacconi, Andrea, Sorci, Melissa, Tito, Claudia   +16 more
core   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Identification and characterization of two RNA silencing suppressors encoded by ophioviruses [PDF]

Virus Research, 2017
Citrus psorosis virus and Mirafiori lettuce big-vein virus are two members of the genus Ophiovirus, family Ophioviridae. So far, how these viruses can interfere in the antiviral RNA silencing pathway is not known. In this study, using a local GFP silencing assay on Nicotiana benthamiana, the 24K-25K and the movement protein (MP) of both viruses were ...
Robles Luna, Gabriel, Reyes, Carina A., Peña, Eduardo J., Ocolotobiche, Eliana, Baeza, Cecilia, Borniego, Maria Belén, Kormelink, Richard, García, María Laura   +7 more
openaire   +5 more sources

Tomato ringspot virus Coat Protein Binds to ARGONAUTE 1 and Suppresses the Translation Repression of a Reporter Gene

Molecular Plant-Microbe Interactions, 2014
RNA silencing regulates plant gene expression and antiviral defenses and functions by cleaving target RNAs or repressing translation. As a counter defense, many plant viruses encode suppressor proteins that sequester small RNAs or inactivate Argonaute ...
Rajita A. Karran, Hélène Sanfaçon
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Poszt-transzkripcionális géncsendesítés és szupresszió molekuláris mechanizmusának feltárása növényekben = Unraveling the mechanism of Post-transcriptional gene silencing and suppression in plants [PDF]

, 2008
Az RNS silencing, egy géninaktivációs mechanizmus, amely szinte az összes eukarióta szervezetben működik, és magába foglalja az állati RNS interferencia és a növényi poszt-ranszkripcionális géncsendesítés (PTGS) jelenségét.
Burgyán, József, Molnár, Attila, Szittya, György, Várallyay, Éva   +3 more
core  

A petunia ethylene-responsive element binding factor, PhERF2, plays an important role in antiviral RNA silencing. [PDF]

, 2016
Virus-induced RNA silencing is involved in plant antiviral defense and requires key enzyme components, including RNA-dependent RNA polymerases (RDRs), Dicer-like RNase III enzymes (DCLs), and Argonaute proteins (AGOs).
Jiang, Cai-Zhong, Nandety, Raja Sekhar, Niu, Lixin, Reid, Michael S, Sun, Daoyang, Zhang, Yanlong   +5 more
core   +1 more source