Results 11 to 20 of about 106,855 (258)

Deciphering the RNA Silencing Suppressor Function in the Potyvirus SPV2 [PDF]

Proceedings, 2020
In most eukaryotes, RNA silencing is a key element in the regulation of gene expression and defense against pathogens. Plants have developed a defensive barrier against exogenous microorganisms, such as plant-infecting viruses, by specifically targeting ...
Ornela Chase, Giannina Bambaren, Juan José López-Moya   +2 more
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Constrained peptides mimic a viral suppressor of RNA silencing [PDF]

Nucleic Acids Research, 2021
Abstract The design of high-affinity, RNA-binding ligands has proven very challenging. This is due to the unique structural properties of RNA, often characterized by polar surfaces and high flexibility. In addition, the frequent lack of well-defined binding pockets complicates the development of small molecule binders.
Arne Kuepper, Niall M McLoughlin, Saskia Neubacher, Alejandro Yeste-Vázquez, Estel Collado Camps, Chandran Nithin, Sunandan Mukherjee, Lucas Bethge, Janusz M Bujnicki, Roland Brock, Stefan Heinrichs, Tom N Grossmann   +11 more
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Modelling the dynamics of viral suppressors of RNA silencing [PDF]

Journal of The Royal Society Interface, 2011
Abstract Virus infection in plants is limited by RNA silencing. In turn, viruses can counter RNA silencing with silencing suppressors. Viral suppressors of RNA silencing have been shown to play a role in symptom development in plants.
Groenenboom, M.A.C., Hogeweg, P.
openaire   +5 more sources

Viral protein inhibits RISC activity by argonaute binding through conserved WG/GW motifs. [PDF]

PLoS Pathogens, 2010
RNA silencing is an evolutionarily conserved sequence-specific gene-inactivation system that also functions as an antiviral mechanism in higher plants and insects. To overcome antiviral RNA silencing, viruses express silencing-suppressor proteins.
Ana Giner, Lóránt Lakatos, Meritxell García-Chapa, Juan José López-Moya, József Burgyán   +4 more
doaj   +1 more source

The Weak Small RNA-Binding Activity of the 2b Proteins of Subgroup II Cucumber Mosaic Virus Strains Is Insufficient for RNA Silencing Suppression

Frontiers in Microbiology, 2021
The 2b proteins encoded by cucumber mosaic virus (CMV) subgroup I strains suppress RNA silencing primarily by competitively binding small RNAs (sRNAs) in the host cell cytoplasm.
Yingying Gao, Jinrui Yang, Xiaobei Zhang, Aizhong Chen, Zhouhang Gu, Zhiyou Du   +5 more
doaj   +1 more source

Oomycete pathogens encode RNA silencing suppressors [PDF]

Nature Genetics, 2013
Effectors are essential virulence proteins produced by a broad range of parasites, including viruses, bacteria, fungi, oomycetes, protozoa, insects and nematodes. Upon entry into host cells, pathogen effectors manipulate specific physiological processes or signaling pathways to subvert host immunity.
Qiao, Yongli, Liu, Lin, Xiong, Qin, Flores, Cristina, Wong, James, Shi, Jinxia, Wang, Xianbing, Liu, Xigang, Xiang, Qijun, Jiang, Shushu, Zhang, Fuchun, Wang, Yuanchao, Judelson, Howard S., Chen, Xuemei, Ma, Wenbo   +14 more
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Recognition of small interfering RNA by a viral suppressor of RNA silencing [PDF]

Nature, 2003
RNA silencing (also known as RNA interference) is a conserved biological response to double-stranded RNA that regulates gene expression, and has evolved in plants as a defence against viruses. The response is mediated by small interfering RNAs (siRNAs), which guide the sequence-specific degradation of cognate messenger RNAs.
Keqiong, Ye, Lucy, Malinina, Dinshaw J, Patel   +2 more
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Identification of Pns6, a putative movement protein of RRSV, as a silencing suppressor

Virology Journal, 2010
RNA silencing is a potent antiviral response in plants. As a counterdefense, most plant and some animal viruses encode RNA silencing suppressors. In this study, we showed that Pns6, a putative movement protein of Rice ragged stunt virus (RRSV), exhibited
Lin Qiying, Wu Zujian, Hu Meiqun, Cai Lijun, Wang Chunzheng, Du Zhenguo, Wu Jianguo, Li Yi, Xie Lianhui   +8 more
doaj   +1 more source

Satellite RNAs interfere with the function of viral RNA silencing suppressors [PDF]

Frontiers in Plant Science, 2015
Viral satellite RNAs (satRNAs) are small subviral RNAs and depend on the helper virus for replication and spread. satRNAs can attenuate helper virus-induced symptoms, the mechanism of which remains unclear. Here, we show that two virus-encoded suppressors of RNA silencing (VSRs), Cucumber mosaic virus (CMV) 2b and Tombusvirus P19, suppress hairpin RNA (
Wanxia eShen, Wanxia eShen, Phil Chi Khang Au, Bu-Jun eShi, Neil A Smith, Elizabeth S. Dennis, Hui-Shan eGuo, Chang-Yong eZhou, Ming-Bo eWang   +8 more
openaire   +4 more sources

Tomato Spotted Wilt Virus NSs Protein Supports Infection and Systemic Movement of a Potyvirus and Is a Symptom Determinant

Viruses, 2018
Plant viruses are inducers and targets of antiviral RNA silencing. To condition susceptibility, most plant viruses encode silencing suppressor proteins that interfere with antiviral RNA silencing.
Hernan Garcia-Ruiz, Sergio M. Gabriel Peralta, Patricia A. Harte-Maxwell   +2 more
doaj   +1 more source