Results 21 to 30 of about 1,384,640 (333)
PLoS Biology, 2023 Fragile X syndrome (FXS) is a neurodevelopmental disorder that is often modeled in Fmr1 knockout mice where the RNA-binding protein FMRP is absent. Here, we show that in Fmr1-deficient mice, RNA mis-splicing occurs in several brain regions and peripheral
Suna Jung +3 more
doaj +1 more source
Genome-wide regulation of KSHV RNA splicing by viral RNA-binding protein ORF57.
PLoS Pathogens, 2022 RNA splicing plays an essential role in the expression of eukaryotic genes. We previously showed that KSHV ORF57 is a viral splicing factor promoting viral lytic gene expression.
Vladimir Majerciak +4 more
doaj +1 more source
Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development
Nature Communications, 2020 RNA editing and RNA splicing are involved in tumorigenesis. Here the authors report crosstalk between RNA editing and splicing by identifying ADAR1/2-dependent splicing events in esophageal squamous carcinoma cells.
Sze Jing Tang +13 more
doaj +1 more source
Molecular Neurodegeneration, 2021 Background Aberrant alternative splicing plays critical role in aging and age-related diseases. Heterogeneous nuclear ribonucleoproteins (hnRNPs) reportedly regulate RNA splicing process. Whether and how hnRNPs contribute to age-related neurodegenerative
Qingyang Zhang +12 more
semanticscholar +1 more source
Pre-mRNA Processing Factors and Retinitis Pigmentosa: RNA Splicing and Beyond
Frontiers in Cell and Developmental Biology, 2021 Retinitis pigmentosa (RP) is the most common inherited retinal disease characterized by progressive degeneration of photoreceptors and/or retinal pigment epithelium that eventually results in blindness. Mutations in pre-mRNA processing factors (PRPF3, 4,
Chunbo Yang +10 more
semanticscholar +1 more source
Global donor and acceptor splicing site kinetics in human cells
eLife, 2019 RNA splicing is an essential part of eukaryotic gene expression. Although the mechanism of splicing has been extensively studied in vitro, in vivo kinetics for the two-step splicing reaction remain poorly understood.
Leonhard Wachutka +3 more
doaj +1 more source
Asian Journal of Andrology, 2023 A complete proteomics study characterizing active androgen receptor (AR) complexes in prostate cancer (PCa) cells identified a diversity of protein interactors with tumorigenic annotations, including known RNA splicing factors.
Sean Seltzer +4 more
doaj +1 more source
Annotation-free quantification of RNA splicing using LeafCutter
Nature Genetics, 2017 The excision of introns from pre-mRNA is an essential step in mRNA processing. We developed LeafCutter to study sample and population variation in intron splicing.
Yang I. Li +6 more
semanticscholar +1 more source
Spliced leader RNA trans-splicing in dinoflagellates [PDF]
Proceedings of the National Academy of Sciences, 2007 Through the analysis of hundreds of full-length cDNAs from fifteen species representing all major orders of dinoflagellates, we demonstrate that nuclear-encoded mRNAs in all species, from ancestral to derived lineages, are trans-spliced with the addition of the 22-nt conserved spliced leader (SL), DCCGUAGCCAUUUUGGCUCAAG (D = U, A, or G), to the 5′ end.
Huan, Zhang +6 more
openaire +2 more sources
Aurora kinase A regulates cancer-associated RNA aberrant splicing in breast cancer
Heliyon, 2023 The contribution of oncogenes to tumor-associated RNA splicing and the relevant molecular mechanisms therein require further elaboration. Here, we show that oncogenic Aurora kinase A (AURKA) promotes breast cancer-related RNA aberrant splicing in a ...
Sisi Li +7 more
doaj +1 more source