Results 31 to 40 of about 210,566 (311)

Catalytic RNA and RNA Splicing [PDF]

American Zoologist, 1989
The capacity of Watson-Crick base-pair complementarity to direct informational transactions basic to gene expression has long been appreciated. Among RNA molecules, it mediates mRNA-tRNA codon-anticodon pairing and the 16S rRNA-mRNA Shine-Dalgarno interaction.
openaire   +2 more sources

Use of a Fluorescent Aptamer RNA as an Exonic Sequence to Analyze Self-Splicing Ability of a Group I Intron from Structured RNAs

Biology, 2016
Group I self-splicing intron constitutes an important class of functional RNA molecules that can promote chemical transformation. Although the fundamental mechanism of the auto-excision from its precursor RNA has been established, convenient assay ...
Airi Furukawa, Takahiro Tanaka, Hiroyuki Furuta, Shigeyoshi Matsumura, Yoshiya Ikawa   +4 more
doaj   +1 more source

AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing

Nature Communications, 2021
IWS1 regulates multiple steps in RNA metabolism, including RNA elongation and alternative RNA splicing. Here the authors show that AKT3 phosphorylates IWS1, which alters U2AF2 RNA splicing and promotes growth of lung adenocarcinomas via a Sororin/ERK ...
Georgios I. Laliotis, Evangelia Chavdoula, Maria D. Paraskevopoulou, Abdul Kaba, Alessandro La Ferlita, Satishkumar Singh, Vollter Anastas, Keith A. Nair, Arturo Orlacchio, Vasiliki Taraslia, Ioannis Vlachos, Marina Capece, Artemis Hatzigeorgiou, Dario Palmieri, Christos Tsatsanis, Salvatore Alaimo, Lalit Sehgal, David P. Carbone, Vincenzo Coppola, Philip N. Tsichlis   +19 more
doaj   +1 more source

Expression of Herpes Simplex Virus Thymidine Kinase/Ganciclovir by RNA Trans-Splicing Induces Selective Killing of HIV-Producing Cells

Molecular Therapy: Nucleic Acids, 2017
Antiviral strategies targeting hijacked cellular processes are less easily evaded by the virus than viral targets. If selective for viral functions, they can have a high therapeutic index.
Carin K. Ingemarsdotter, Sushmita Poddar, Sarah Mercier, Volker Patzel, Andrew M.L. Lever   +4 more
doaj   +1 more source

Intronic noncoding RNAs and splicing

Trends in Plant Science, 2008
The gene organization of small nucleolar RNAs (snoRNAs) and microRNAs (miRNAs) varies within and among different organisms. This diversity is reflected in the maturation pathways of these small noncoding RNAs (ncRNAs). The presence of noncoding RNAs in introns has implications for the biogenesis of both mature small RNAs and host mRNA.
Brown, John W. S., Marshall, David F., Echeverria, Manuel   +2 more
openaire   +5 more sources

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Splicing of Messenger RNA Precursors

Science, 1987
A general mechanism for the splicing of nuclear messenger RNA precursors in eukaryotic cells has been widely accepted. This mechanism, which generates lariat RNAs possessing a branch site, seems related to the RNA-catalyzed reactions of self-splicing introns.
Sharp, P. A., Konarska, M. M., Grabowski, P. J., Lamond, A. I., Marciniak, R., Seiler, S. R.   +5 more
openaire   +8 more sources

PCB: A pseudotemporal causality-based Bayesian approach to identify EMT-associated regulatory relationships of AS events and RBPs during breast cancer progression.

PLoS Computational Biology, 2023
During breast cancer metastasis, the developmental process epithelial-mesenchymal (EM) transition is abnormally activated. Transcriptional regulatory networks controlling EM transition are well-studied; however, alternative RNA splicing also plays a ...
Liangjie Sun, Yushan Qiu, Wai-Ki Ching, Pu Zhao, Quan Zou   +4 more
doaj   +1 more source

Alternative RNA Splicing in Fatty Liver Disease

Frontiers in Endocrinology, 2021
Alternative RNA splicing is a process by which introns are removed and exons are assembled to construct different RNA transcript isoforms from a single pre-mRNA.
Panyisha Wu, Moya Zhang, Nicholas J. G. Webster, Nicholas J. G. Webster, Nicholas J. G. Webster   +4 more
doaj   +1 more source

RNA splicing: Out of the loop [PDF]

Current Biology, 1997
Recent functional analysis of catalytic and exon-binding domains from group II autocatalytic introns has revealed haunting similarities with small nuclear RNA sequences in the spliceosome.
openaire   +3 more sources