Results 31 to 40 of about 1,384,640 (333)
Determination of RNA structural diversity and its role in HIV-1 RNA splicing
Nature, 2020 Human immunodeficiency virus 1 (HIV-1) is a retrovirus with a ten-kilobase single-stranded RNA genome. HIV-1 must express all of its gene products from a single primary transcript, which undergoes alternative splicing to produce diverse protein products ...
Phillip Tomezsko +16 more
semanticscholar +1 more source
ISVASE: identification of sequence variant associated with splicing event using RNA-seq data
BMC Bioinformatics, 2017 Background Exon recognition and splicing precisely and efficiently by spliceosome is the key to generate mature mRNAs. About one third or a half of disease-related mutations affect RNA splicing.
Hasan Awad Aljohi +4 more
doaj +1 more source
Structural insights into RNA splicing [PDF]
Current Opinion in Structural Biology, 2009 Intron splicing is a fundamental biological process whereby noncoding sequences are removed from precursor RNAs. Recent work has provided new insights into the structural features and reaction mechanisms of two introns that catalyze their own splicing from precursor RNA: the group I and II introns.
Navtej, Toor +2 more
openaire +2 more sources
Linking splicing to Pol II transcription stabilizes pre-mRNAs and influences splicing patterns.
PLoS Biology, 2006 RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing. Using an in vitro transcription/splicing assay, we demonstrate that an association of RNA polymerase ...
Martin J Hicks +3 more
doaj +1 more source
Mutations in the RNA splicing factor SF3B1 promote tumorigenesis through MYC stabilization.
Cancer Discovery, 2020 Although mutations in the RNA splicing factor SF3B1 are frequent in multiple cancers, their functional effects and therapeutic dependencies are poorly understood. Here we characterize 98 tumors and 12 isogenic cell lines harboring SF3B1 hotspot mutations,
Zhaoqi Liu +15 more
semanticscholar +1 more source
npj Precision Oncology, 2020 Germline variants in tumor suppressor genes (TSGs) can result in RNA mis-splicing and predisposition to cancer. However, identification of variants that impact splicing remains a challenge, contributing to a substantial proportion of patients with ...
Tyler Landrith +52 more
doaj +1 more source
An overview of RNA splicing and functioning of splicing factors in land plant chloroplasts
RNA Biology, 2022 RNA splicing refers to a process by which introns of a pre-mRNA are excised and the exons at both ends are joined together. Chloroplast introns are inherently self-splicing ribozymes, but over time, they have lost self-splicing ability due to the ...
Xuemei Wang +4 more
doaj +1 more source
RNA structure and splicing regulation [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019 The process of pre-mRNA splicing is fundamental to gene regulation in eukaryotes. Specific RNA sequences called introns, which do not code for amino acids, are removed during pre-mRNA splicing, and flanking sequences are spliced together as exons forming mRNAs that are exported to the cytosol.
Baralle, Francisco E. +2 more
openaire +3 more sources
hnRNP A1 dysfunction alters RNA splicing and drives neurodegeneration in multiple sclerosis (MS)
Nature CommunicationsHnRNP A1 dysfunction is associated with neurodegeneration in multiple sclerosis (MS). Herein, advanced RNA sequencing and CLIPseq of MS brains and relevant models demonstrated that hnRNP A1 binding of target RNAs and RNA splicing were altered ...
Hannah E. Salapa +11 more
semanticscholar +1 more source
A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation, and RNA splicing
EMBO Journal, 2018 TDP‐43 is an RNA‐binding protein active in splicing that concentrates into membraneless ribonucleoprotein granules and forms aggregates in amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. Although best known for its predominantly disordered C‐
Ailin Wang +14 more
semanticscholar +1 more source