Results 61 to 70 of about 384,167 (334)
Saturation mutagenesis reveals manifold determinants of exon definition. [PDF]
, 2017 To illuminate the extent and roles of exonic sequences in the splicing of human RNA transcripts, we conducted saturation mutagenesis of a 51-nt internal exon in a three-exon minigene.
Anquetil, Vincent +9 more
core +2 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Alternative RNA Splicing in Fatty Liver Disease
Frontiers in Endocrinology, 2021 Alternative RNA splicing is a process by which introns are removed and exons are assembled to construct different RNA transcript isoforms from a single pre-mRNA.
Panyisha Wu +4 more
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Alternative Splicing in Myeloid Malignancies
Biomedicines, 2021 Alternative RNA splicing (AS) is an essential physiologic function that diversifies the human proteome. AS also has a crucial role during cellular development.
Carmelo Gurnari +2 more
doaj +1 more source
Coupling and Coordination in Gene Expression Processes with Pre-mRNA Splicing [PDF]
, 2015 A processing is a tightly regulated and highly complex pathway which includes transcription, splicing, editing, transportation, translation and degradation.
Huang, Z, Lee, JTH, Pan, K, Wong, CM
core +2 more sources
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
RNA splicing: Unexpected spliceosome diversity [PDF]
Current Biology, 1996 A novel form of spliceosome, containing the minor snRNPs U11 and U12, splices a class of pre-mRNA introns with non-consensus splice sites. This unexpected spliceosome diversity has interesting implications for the evolution and expression of eukaryotic genes.
Kreivi, Jan Peter, Lamond, Angus I.
openaire +3 more sources
Molecular Therapy: Nucleic Acids, 2017 Antiviral strategies targeting hijacked cellular processes are less easily evaded by the virus than viral targets. If selective for viral functions, they can have a high therapeutic index.
Carin K. Ingemarsdotter +4 more
doaj +1 more source
Transcriptomic and genomic identification of spliceosomal genes from Euglena gracilis
Acta Biochimica et Biophysica Sinica, 2023 Diverse splicing types in nuclear and chloroplast genes of protist Euglena gracilis have been recognized for decades. However, the splicing machinery responsible for processing nuclear precursor messenger RNA introns, including
Gao Pingwei, Zhong Yujie, Sun Chengfu
doaj +1 more source