Results 161 to 170 of about 156,310 (280)

Activation and Spatial Redistribution of RNA Splicing Factors Trigger Hepatic Regeneration. [PDF]

Cell Mol Gastroenterol Hepatol
An Y, Lian J, Wei W, Mao Y, Qiao L, Li T, Li R, Li S, Zhao S, Chen X, Zhao H, Hu H.   +11 more
europepmc   +1 more source

Cloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43

, 1997
Sherry L. Gee, Sharon Wald Krauss, Estelle Miller, Kazuko Aoyagi, Jaime E. Arenas, John G. Conboy   +5 more
openalex   +2 more sources

Role of RNA splicing in mediating lineage-specific expression of the von Willebrand factor gene in the endothelium [PDF]

, 2013
Lei Yuan, Lauren Janes, David Beeler, Katherine Spokes, J. A. Smith, Dan Li, Shou-Ching Jaminet, Peter Oettgen, William C. Aird   +8 more
openalex   +1 more source

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

Advanced Science, EarlyView.
Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao, Qian Hao, Yu Gan, Jing Tong, Xiaodan Chen, Shuran Tan, Ruiwen Ruan, Yingdan Huang, Mingming Cao, Jun Deng, Tao Han, Getao Shi, Bo Gao, Yu Zhang, Xiang Zhou   +14 more
wiley   +1 more source

The efficacy of longevity interventions in Caenorhabditis elegans is determined by the early life activity of RNA splicing factors. [PDF]

PLoS Biol
Dutta S, Perez Matos MC, Heintz C, Mutlu AS, Piper M, Mistry M, Sharma A, Morrow CS, Smith H, Howell P, Sehgal R, Lanjuin A, Wang MC, Mair WB.   +13 more
europepmc   +1 more source

Kaposi's Sarcoma-Associated Herpesvirus ORF57 Functions as a Viral Splicing Factor and Promotes Expression of Intron-Containing Viral Lytic Genes in Spliceosome-Mediated RNA Splicing

, 2008
Vladimır Majerčiak, Koji Yamanegi, Eric Allemand, Michael J. Kruhlak, Adrian R. Krainer, Zhi‐Ming Zheng   +5 more
openalex   +2 more sources

The Splicing Factor RNA-Binding Fox Protein 1 Mediates the Cellular Immune Response in Drosophila melanogaster [PDF]

, 2018
Ashley Nazario-Toole, Javier Robalino, Kwame Okrah, Héctor Corrada Bravo, Stephen M. Mount, Louisa P. Wu   +5 more
openalex   +1 more source

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

Autopolyploidization‐Induced Chromatin Remodeling Regulates Leaf Size Variation in Brassica rapa

Advanced Science, EarlyView.
This study demonstrates that monoploid, diploid, and autotetraploid Brassica rapa lines derived from the same genome exhibit distinct leaf morphology. Ploidy changes remodel chromatin accessibility and histone modifications to regulate gene expression, while key transcription factors BrGRF13 and BrARF11 control leaf size and polarity, driving ...
Haoyuan Dong, Yanhong Liu, Yuanming Liu, Shuxin Xuan, Huanhuan Chen, Lai Wei, Guibao Zhang, Hongcui Pei, Zilong Dai, Yanhua Wang, Jinzhu Qiao, Shuangxia Luo, Xueping Chen, Yiguo Hong, Jianjun Zhao, Shuxing Shen, Zefu Lu, Aixia Gu   +17 more
wiley   +1 more source

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source