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Alternative splicing: from tumorigenesis to neoantigen-mediated cancer immunotherapy. [PDF]
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Mutations of RNA splicing factors in hematological malignancies
Cancer Letters, 2017Systematic large-scale cancer genomic studies have produced numerous significant findings. These studies have not only revealed new cancer-promoting genes, but they also have identified cancer-promoting functions of previously known "housekeeping" genes.
Girish C. Shukla, Jagjit Singh
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The role of RNA splicing factor PTBP1 in neuronal development
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2023Alternative pre-mRNA splicing, which produces various mRNA isoforms with distinct structures and functions from a single gene, is regulated by specific RNA-binding proteins and is an essential method for regulating gene expression in mammals. Recent studies have shown that abnormal change during neuronal development triggered by splicing mis-regulation
Hui-Lin, Liu +8 more
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The RNA splicing factor hSlu7 is required for correct 3′ splice-site choice
Nature, 1999The production of correctly spliced messenger RNA requires two catalytic splicing steps. During step II, exon 1 attacks an adenine-guanine (AG) dinucleotide at the 3' splice site. This AG is usually located between 18 and 40 nucleotides downstream from the branch site, and closer AGs are skipped in favour of AGs located more optimally downstream.
K, Chua, R, Reed
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Nature Structural & Molecular Biology, 2006
Coupling between transcription and RNA processing is a key gene regulatory mechanism. Here we use chromatin immunoprecipitation to detect transcription-dependent accumulation of the precursor mRNA (pre-mRNA) splicing factors hnRNP A1, U2AF65 and U1 and U5 snRNPs on the intron-containing human FOS gene.
Listerman, I., Sapra, A., Neugebauer, K.
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Coupling between transcription and RNA processing is a key gene regulatory mechanism. Here we use chromatin immunoprecipitation to detect transcription-dependent accumulation of the precursor mRNA (pre-mRNA) splicing factors hnRNP A1, U2AF65 and U1 and U5 snRNPs on the intron-containing human FOS gene.
Listerman, I., Sapra, A., Neugebauer, K.
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