Results 271 to 280 of about 8,269,931 (302)
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Experimental Cell Research, 2003
Subcellular compartmentalization of splicing factors has been proposed to play a role in the regulation of alternative splicing. In the present work we have addressed this issue using adenovirus-infected cells to visualize an alternative splicing switch at the single cell level.
Gama-Carvalho, Margarida +2 more
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Subcellular compartmentalization of splicing factors has been proposed to play a role in the regulation of alternative splicing. In the present work we have addressed this issue using adenovirus-infected cells to visualize an alternative splicing switch at the single cell level.
Gama-Carvalho, Margarida +2 more
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The RNA splicing factor hSlu7 is required for correct 3′ splice-site choice
Nature, 1999The production of correctly spliced messenger RNA requires two catalytic splicing steps. During step II, exon 1 attacks an adenine-guanine (AG) dinucleotide at the 3' splice site. This AG is usually located between 18 and 40 nucleotides downstream from the branch site, and closer AGs are skipped in favour of AGs located more optimally downstream.
K, Chua, R, Reed
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Nature Structural & Molecular Biology, 2006
Coupling between transcription and RNA processing is a key gene regulatory mechanism. Here we use chromatin immunoprecipitation to detect transcription-dependent accumulation of the precursor mRNA (pre-mRNA) splicing factors hnRNP A1, U2AF65 and U1 and U5 snRNPs on the intron-containing human FOS gene.
Listerman, I., Sapra, A., Neugebauer, K.
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Coupling between transcription and RNA processing is a key gene regulatory mechanism. Here we use chromatin immunoprecipitation to detect transcription-dependent accumulation of the precursor mRNA (pre-mRNA) splicing factors hnRNP A1, U2AF65 and U1 and U5 snRNPs on the intron-containing human FOS gene.
Listerman, I., Sapra, A., Neugebauer, K.
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Alternatively spliced isoforms of a novel stromal RNA regulating factor
Gene, 2004Bone marrow stromal cells (MSC) are pluripotent cells that possess a unique capacity to differentiate under appropriate conditions into various lineages. The MSC differentiation is dependent on factors that can switch on and maintain a relevant genetic program to make a particular cell type.
I, Shur, D, Ben-Avraham, D, Benayahu
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Characterization of a splicing mutation in the factor VIII gene at the RNA level
Human Genetics, 1995Haemophilia A is an X-linked bleeding disorder caused by mutations in the coagulation factor VIII (FVIII) gene. The identification and characterization of naturally occurring disease-producing mutations allows the recognition of new mechanisms of pathogenesis in haemophilia A. Analysis of the illegitimately transcribed FVIII mRNA in a severely affected
D, David, A, Tavares, J, Lavinha
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Non-Canonical Functions of Splicing Factors in RNA Metabolism
Critical Reviews in Plant Sciences, 2020Noncoding RNA (ncRNA), such as microRNA (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs) play roles in plant growth, development, and response to environmental cues via diverse manners...
Xiao Han +3 more
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2016
The majority of human genes undergo alternative splicing to produce multiple isoforms with distinct functions. The dysregulations of alternative splicing have been found to be closely associated with various human diseases; thus new approaches to modulate disease-associated splicing events will provide great therapeutic potentials.
Yang, Wang, Zefeng, Wang
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The majority of human genes undergo alternative splicing to produce multiple isoforms with distinct functions. The dysregulations of alternative splicing have been found to be closely associated with various human diseases; thus new approaches to modulate disease-associated splicing events will provide great therapeutic potentials.
Yang, Wang, Zefeng, Wang
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The role of RNA splicing factors in the regulation of longevity
2021Geroscience aims to target the aging process to extend healthspan. However, the efficacy of pro- longevity interventions is highly heterogeneous, limiting their translational potential. In my dissertation research, I discovered that activity of RNA splicing factors REPO-1 and SFA-1 early in life, modulates effectiveness of known longevity interventions
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Identification of a family of DNA-binding proteins with homology to RNA splicing factors
Biochemistry and Cell Biology, 2006We describe a unique family of human proteins that are capable of binding to the cAMP regulatory element (CRE) and that are homologous to RNA splicing proteins. A human cDNA was isolated that encodes a protein with a distinctive combination of modular domain structures: 2 leucine-zipper-like domains, a DNA-binding zinc-finger-like domain, an RNA ...
Kristy L, Shipman +4 more
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The conserved role of RNA splicing factors in genome maintenance
2020RNA splicing mutants have been broadly implicated in genome stability, but mechanistic links are often unclear. Two predominant models have emerged: one involving changes in gene expression that perturb other genome maintenance factors and another in which genotoxic DNA:RNA hybrids, called R-loops, impair DNA replication. Recent efforts in whole genome
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