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RNA splicing factor Rbm25 underlies heterogeneous preleukemic clonal expansion in mice
Blood, 2023Clonal expansion sets the stage for cancer genesis by allowing for the accumulation of molecular alterations. While genetic mutations that induce clonal expansion and malignancy, such as Tet2, have been identified, these mutations are also frequently found in healthy individuals.
Charles Bramlett +8 more
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Differential RNA splicing predicts two distinct nerve growth factor precursors
Nature, 1986Nerve growth factor (NGF) has a crucial role in the development of sensory and sympathetic neurones. However, although it can affect other neural cell types under certain experimental conditions, no biological role has been convincingly demonstrated elsewhere in the nervous system.
R H, Edwards, M J, Selby, W J, Rutter
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Non-Canonical Functions of Splicing Factors in RNA Metabolism
Critical Reviews in Plant Sciences, 2020Noncoding RNA (ncRNA), such as microRNA (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs) play roles in plant growth, development, and response to environmental cues via diverse manners...
Xiao Han +3 more
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Alternatively spliced isoforms of a novel stromal RNA regulating factor
Gene, 2004Bone marrow stromal cells (MSC) are pluripotent cells that possess a unique capacity to differentiate under appropriate conditions into various lineages. The MSC differentiation is dependent on factors that can switch on and maintain a relevant genetic program to make a particular cell type.
I, Shur, D, Ben-Avraham, D, Benayahu
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2016
The majority of human genes undergo alternative splicing to produce multiple isoforms with distinct functions. The dysregulations of alternative splicing have been found to be closely associated with various human diseases; thus new approaches to modulate disease-associated splicing events will provide great therapeutic potentials.
Yang, Wang, Zefeng, Wang
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The majority of human genes undergo alternative splicing to produce multiple isoforms with distinct functions. The dysregulations of alternative splicing have been found to be closely associated with various human diseases; thus new approaches to modulate disease-associated splicing events will provide great therapeutic potentials.
Yang, Wang, Zefeng, Wang
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Regulation of Cellular RNA Nano-Particle Assembly by Splicing Factor SRp20
Journal of Nanoscience and Nanotechnology, 2013Cellular RNA nano-particles (RNA granules) such as stress granule (SG) and P-body (PB) are translationally silenced mRNA-protein complexes. Previously, a genome-wide loss-of-function screen using oligomeric siRNAs targeting potential drug target genes was performed to identify genes that are involved in SG and PB assembly.
Sang Pil, Yoon +4 more
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Multiple roles of arginine/serine-rich splicing factors in RNA processing
Biochemical Society Transactions, 2005SR proteins (serine- and arginine-rich proteins) are an evolutionarily conserved family consisting of essential pre-mRNA splicing factors. Since their discovery and initial characterization, roles of SR proteins in pre-mRNA splicing and in subsequent steps of post-transcriptional gene expression have expanded significantly.
J R, Sanford, J, Ellis, J F, Cáceres
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Cell-type-specific splicing factors and the regulation of alternative RNA splicing.
The New biologist, 1991A very wide variety of biological processes are regulated by alternative splicing. By this means, a gene can be transcribed in several different tissues but in each tissue the RNA transcript is spliced in a particular way to produce a different mRNA and hence a different protein.
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Dual DNA/RNA-binding factor regulates dynamics of hnRNP splicing condensates
AbstractDespite decades of research, mechanisms by which co-transcriptional alternative splicing events are targeted to the correct genomic locations to drive cell fate decisions remain unknown. By combining structural and molecular approaches, we define a new mechanism by which an essential transcription factor (TF) targets co-transcriptional splicingMukulika Ray +14 more
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The RNA Splicing Factor RBM25 in Preleukemic Clonal Expansion
Oncology Times, 2023openaire +1 more source