N6-methyladenosine RNA modification promotes viral genomic RNA stability and infection. [PDF]
Nat Commun, 2022 Molecular manipulation of susceptibility (S) genes that are antipodes to resistance (R) genes has been adopted as an alternative strategy for controlling crop diseases.
Zhang T +16 more
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RNA Stability: A Review of the Role of Structural Features and Environmental Conditions. [PDF]
MoleculesThe stability of RNA is a critical factor in determining its functionality and degradation in the cell. In recent years, it has been shown that the stability of RNA depends on a complex interaction of external and internal factors.
Kornienko IV +4 more
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Characterizing RNA stability genome-wide through combined analysis of PRO-seq and RNA-seq data. [PDF]
BMC Biol, 2021 The concentrations of distinct types of RNA in cells result from a dynamic equilibrium between RNA synthesis and decay. Despite the critical importance of RNA decay rates, current approaches for measuring them are generally labor-intensive, limited in ...
Blumberg A +8 more
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Regulation of RNA stability at the 3' end. [PDF]
Biol Chem, 2021 Abstract RNA homeostasis is regulated by a multitude of cellular pathways. Although the addition of untemplated adenine residues to the 3′ end of mRNAs has long been known to affect RNA stability, newly developed techniques for 3′-end sequencing of RNAs have revealed various unexpected RNA modifications.
Frederick MI, Heinemann IU.
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Low RNA stability signifies increased post-transcriptional regulation of cell identity genes. [PDF]
Nucleic Acids Res, 2023 Cell identity genes are distinct from other genes with respect to the epigenetic mechanisms to activate their transcription, e.g. by super-enhancers and broad H3K4me3 domains.
Li Y +14 more
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Riboswitch control of bacterial RNA stability. [PDF]
Mol Microbiol, 2021 Although riboswitches have long been known to regulate translation initiation and transcription termination, a growing body of evidence indicates that they can also control bacterial RNA lifetimes by acting directly to hasten or impede RNA degradation ...
Richards J, Belasco JG.
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Epitranscriptomic addition of m6A regulates HIV-1 RNA stability and alternative splicing. [PDF]
Genes Dev, 2021 Previous work in several laboratories has demonstrated that the epitranscriptomic addition of m6A to viral transcripts promotes the replication and pathogenicity of a wide range of DNA and RNA viruses, yet the underlying mechanisms responsible for this ...
Tsai K +5 more
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Structural analyses of an RNA stability element interacting with poly(A). [PDF]
Proc Natl Acad Sci U S A, 2021 Significance RNA triple helices were characterized in vitro over 60 y ago, but only recently implicated in diverse biological activities. The element for nuclear expression (ENE) protects RNA from degradation via triplex formation with the poly(A) tail ...
Torabi SF +10 more
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Acetylation of Cytidine Residues Boosts HIV-1 Gene Expression by Increasing Viral RNA Stability. [PDF]
Cell Host Microbe, 2020 Covalent modifications added to individual nucleotides on mRNAs, called epitranscriptomic modifications, have recently emerged as key regulators of both cellular and viral mRNA function1,2 and RNA methylation has now been shown to enhance the replication
Tsai K +5 more
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METTL3 Modulates Osteoclast Differentiation and Function by Controlling RNA Stability and Nuclear Export. [PDF]
Int J Mol Sci, 2020 Osteoclast differentiation and function are crucial for maintaining bone homeostasis and preserving skeletal integrity. N6-methyladenosine (m6A) is an abundant mRNA modification that has recently been shown to be important in regulating cell lineage ...
Li D, Cai L, Meng R, Feng Z, Xu Q.
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