Results 1 to 10 of about 511,041 (280)

Unveiling RNA structure-mediated regulations of RNA stability in wheat [PDF]

Nature Communications
Despite the critical role of mRNA stability in post-transcriptional gene regulation, research on this topic in wheat, a vital agricultural crop, remains unclear. Our study investigated the mRNA decay landscape of durum wheat (Triticum turgidum L.
Haidan Wu, Haopeng Yu, Yueying Zhang, Bibo Yang, Wenqing Sun, Lanying Ren, Yuchen Li, Qianqian Li, Bao Liu, Yiliang Ding, Huakun Zhang   +10 more
doaj   +4 more sources

Abnormal RNA stability in amyotrophic lateral sclerosis [PDF]

Nature Communications, 2018
RNA instability may be a contributing factor in amyotrophic lateral sclerosis (ALS). Here the authors carry out genome-wide assessment of RNA synthesis and stability in cells derived from patients with C9orf72 ALS, sporadic ALS and healthy controls.
E. M. Tank, C. Figueroa-Romero, L. M. Hinder, K. Bedi, H. C. Archbold, X. Li, K. Weskamp, N. Safren, X. Paez-Colasante, C. Pacut, S. Thumma, M. T. Paulsen, K. Guo, J. Hur, M. Ljungman, E. L. Feldman, S. J. Barmada   +16 more
doaj   +2 more sources

VfoldCPX Server: Predicting RNA-RNA Complex Structure and Stability. [PDF]

PLoS ONE, 2016
RNA-RNA interactions are essential for genomic RNA dimerization, mRNA splicing, and many RNA-related gene expression and regulation processes. The prediction of the structure and folding stability of RNA-RNA complexes is a problem of significant ...
Xiaojun Xu, Shi-Jie Chen
doaj   +4 more sources

N6-methyladenosine RNA modification promotes viral genomic RNA stability and infection [PDF]

Nature Communications, 2022
Wheat production is threatened by wheat yellow mosaic virus (WYMV). Here, via genome-wide association study, the authors report that a putative methyltransferase B positively regulates WYMV infection through enhancing viral genomic RNA stability by N6 ...
Tianye Zhang, Chaonan Shi, Haichao Hu, Zhuo Zhang, Ziqiong Wang, Zhiqing Chen, Huimin Feng, Peng Liu, Jun Guo, Qisen Lu, Kaili Zhong, ZhiHui Chen, Jiaqian Liu, Jiancheng Yu, Jianping Chen, Feng Chen, Jian Yang   +16 more
doaj   +2 more sources

RNA Stability: A Review of the Role of Structural Features and Environmental Conditions [PDF]

Molecules
The stability of RNA is a critical factor in determining its functionality and degradation in the cell. In recent years, it has been shown that the stability of RNA depends on a complex interaction of external and internal factors.
Igor V. Kornienko, Olga Yu. Aramova, Anna A. Tishchenko, Dmitriy V. Rudoy, Michael Leonidas Chikindas   +4 more
doaj   +2 more sources

Methylglyoxal-induced RNA modifications decrease RNA stability and translation and are associated with type 2 diabetes [PDF]

Molecular Metabolism
Objectives: Methylglyoxal (MG), a reactive aldehyde generated as a byproduct of glucose and lipid metabolism, is known to modify nucleic acids and proteins, altering their structure and function.
Edwin De Jesus Lopez Gonzalez, SWT Lai, Kelani Sun, Caree R. Carson, Carlos Hernandez-Castillo, Tala Zoukari, Kassandra Lopez, Jianying Zhang, Thomas Blevins, John Termini, Sarah C. Shuck   +10 more
doaj   +2 more sources

Reversible 2'-OH acylation enhances RNA stability. [PDF]

Nat Chem, 2023
Abstract Stabilization of RNAs for storage, transport, and biological application remains a serious challenge, particularly for larger RNAs that are not accessible by chemical synthesis. Here, we present reversible 2’-OH acylation as a general strategy to preserve RNA of any length or origin. High-yield polyacylation of 2’-hydroxyls (“cloaking”)
Fang L, Xiao L, Jun YW, Onishi Y, Kool ET.   +4 more
europepmc   +3 more sources

RNA stability is regulated by both RNA polyadenylation and ATP levels, linking RNA and energy metabolisms in Escherichia coli [PDF]

mBio
The post-transcriptional process of RNA polyadenylation sits at the crossroads of energy metabolism and RNA metabolism. RNA polyadenylation is catalyzed by poly(A) polymerases, which use ATP as a substrate to add adenine to the 3′ end of RNAs, which can ...
Charlotte Roux, Marvin Ramos-Hue, Marjorie Audonnet, Marie-Pierre Duviau, Sébastien Nouaille, Agamemnon J. Carpousis, Sandrine Laguerre, Eliane Hajnsdorf, Muriel Cocaign-Bousquet, Laurence Girbal   +9 more
doaj   +2 more sources

Multiplexed assays of human disease-relevant mutations reveal UTR dinucleotide composition as a major determinant of RNA stability [PDF]

eLife
Untranslated regions (UTRs) contain crucial regulatory elements for RNA stability, translation and localization, so their integrity is indispensable for gene expression. Approximately 3.7% of genetic variants associated with diseases occur in UTRs, yet a
Jia-Ying Su, Yun-Lin Wang, Yu-Tung Hsieh, Yu-Chi Chang, Cheng-Han Yang, YoonSoon Kang, Yen-Tsung Huang, Chien-Ling Lin   +7 more
doaj   +2 more sources

RNA stability: a novel perspective on gene regulatory networks in bovine mastitis [PDF]

BMC Genomics
Mastitis is a common and multifactorial disease in dairy cattle that leads to a major challenge in the livestock industry, in terms of both animal welfare and economic factors.
Mohammad Amin Shirazi, Mohammad Reza Bakhtiarizadeh, Abdolreza Salehi   +2 more
doaj   +2 more sources