Results 11 to 20 of about 4,719,315 (357)

Abnormal RNA stability in amyotrophic lateral sclerosis

Nature Communications, 2018
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share key features, including accumulation of the RNA-binding protein TDP-43.
Elizabeth H M Tank, Claudia Figueroa-Romero, L. Hinder, Karan Bedi, H. C. Archbold, Xingli Li, Kaitlin Weskamp, Nathaniel Safren, X. Paez-Colasante, Crystal M Pacut, S. Thumma, M. Paulsen, K. Guo, J. Hur, M. Ljungman, E. Feldman, S. Barmada   +16 more
semanticscholar   +2 more sources

The emerging role of RNA modifications in the regulation of mRNA stability

Experimental and Molecular Medicine, 2020
Many studies have highlighted the importance of the tight regulation of mRNA stability in the control of gene expression. mRNA stability largely depends on the mRNA nucleotide sequence, which affects the secondary and tertiary structures of the mRNAs ...
Sung Ho Boo, Yoon Ki Kim
semanticscholar   +2 more sources

Stability of SARS-CoV-2 RNA in Nonsupplemented Saliva

Emerging Infectious Diseases, 2021
The expense of saliva collection devices designed to stabilize severe acute respiratory syndrome coronavirus 2 RNA is prohibitive to mass testing. However, virus RNA in nonsupplemented saliva is stable for extended periods and at elevated temperatures ...
I. Ott, M. Strine, A. Watkins, M. Boot, C. Kalinich, Christina A. Harden, C. Vogels, A. Casanovas-Massana, A. Moore, M. C. Muenker, Maura I Nakahata, M. Tokuyama, A. Nelson, John B. Fournier, S. Bermejo, M. Campbell, R. Datta, C. D. Dela Cruz, S. Farhadian, A. Ko, A. Iwasaki, N. Grubaugh, Craig B. Wilen, A. Wyllie   +23 more
semanticscholar   +3 more sources

Expanding Access to HIV Viral Load Testing: A Systematic Review of RNA Stability in EDTA Tubes and PPT beyond Current Time and Temperature Thresholds

PLoS ONE, 2014
Background HIV viral load (VL) testing is the gold standard for antiretroviral treatment monitoring, but many barriers exist to VL testing in resource-limited settings, including storage and transport limitations for whole blood and plasma.
K. Bonner, R. Siemieniuk, Andrew S. Boozary, T. Roberts, E. Fajardo, J. Cohn   +5 more
semanticscholar   +2 more sources

Unveiling RNA structure-mediated regulations of RNA stability in wheat. [PDF]

Nat Commun
Despite the critical role of mRNA stability in post-transcriptional gene regulation, research on this topic in wheat, a vital agricultural crop, remains unclear. Our study investigated the mRNA decay landscape of durum wheat (Triticum turgidum L.
Wu H, Yu H, Zhang Y, Yang B, Sun W, Ren L, Li Y, Li Q, Liu B, Ding Y, Zhang H.   +10 more
europepmc   +2 more sources

Methylglyoxal-induced RNA modifications decrease RNA stability and translation and are associated with type 2 diabetes. [PDF]

Mol Metab
Objectives: Methylglyoxal (MG), a reactive aldehyde generated as a byproduct of glucose and lipid metabolism, is known to modify nucleic acids and proteins, altering their structure and function.
Lopez Gonzalez EJ, Lai S, Sun K, Carson CR, Hernandez-Castillo C, Zoukari T, Lopez K, Zhang J, Blevins T, Termini J, Shuck SC.   +10 more
europepmc   +2 more sources

Multiplexed assays of human disease-relevant mutations reveal UTR dinucleotide composition as a major determinant of RNA stability. [PDF]

Elife
Untranslated regions (UTRs) contain crucial regulatory elements for RNA stability, translation and localization, so their integrity is indispensable for gene expression. Approximately 3.7% of genetic variants associated with diseases occur in UTRs, yet a
Su JY, Wang YL, Hsieh YT, Chang YC, Yang CH, Kang Y, Huang YT, Lin CL.   +7 more
europepmc   +2 more sources

RNA stability is regulated by both RNA polyadenylation and ATP levels, linking RNA and energy metabolisms in Escherichia coli. [PDF]

mBio
The post-transcriptional process of RNA polyadenylation sits at the crossroads of energy metabolism and RNA metabolism. RNA polyadenylation is catalyzed by poly(A) polymerases, which use ATP as a substrate to add adenine to the 3′ end of RNAs, which can ...
Roux C, Ramos-Hue M, Audonnet M, Duviau M-P, Nouaille S, Carpousis AJ, Laguerre S, Hajnsdorf E, Cocaign-Bousquet M, Girbal L.   +9 more
europepmc   +2 more sources

Stability of RNA Molecules Stored in GITC

BioTechniques, 1998
Rebecca C. Gilleland, Richard D. Hockett
openaire   +5 more sources

Post-mortem Interval and Its Relation with the RNA Degradation in the Dental Pulp in Submerged Teeth

Arab Journal of Forensic Sciences & Forensic Medicine, 2021
Post-mortem interval is the time between death and the discovery of the body or human remains. Teeth are the most resistant structures of the human body, able to withstand extreme conditions such as high temperature, humidity, and post-mortem degradation.
Bruna S. Borges, Thiago José Dionísio, Carlos Ferreira dos Santos, Ricardo Henrique Alves da Silva   +3 more
doaj   +1 more source