Results 21 to 30 of about 522,625 (254)
Hybridization Properties of RNA Containing 8-Methoxyguanosine and 8-Benzyloxyguanosine. [PDF]
PLoS ONE, 2015 Modified nucleobase analogues can serve as powerful tools for changing physicochemical and biological properties of DNA or RNA. Guanosine derivatives containing bulky substituents at 8 position are known to adopt syn conformation of N-glycoside bond.
Daniel Sylwester Baranowski +3 more
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The emerging role of RNA modifications in the regulation of mRNA stability
Experimental and Molecular Medicine, 2020 Gene activity: the significance of RNA modification Messenger RNA molecules play their key role in directing the manufacture of proteins via translating the genetic information in DNA.
Sung Ho Boo, Yoon Ki Kim
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Stability of RNA virus attenuation approaches [PDF]
Vaccine, 2011 The greatest risk from live-attenuated vaccines is reversion to virulence. Particular concerns arise for RNA viruses, which exhibit high mutation frequencies. We examined the stability of 3 attenuation strategies for the alphavirus, Venezuelan equine encephalitis virus (VEEV): a traditional, point mutation-dependent attenuation approach exemplified by ...
Joan L, Kenney +5 more
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Immunostimulating capacities of stabilized RNA molecules [PDF]
European Journal of Immunology, 2004 AbstractSince direct injection of naked mRNA induces an immune response, we tested the capacity of RNA to signal danger. We show here that mRNA molecules that are protected from immediate degradation either through interaction with cationic proteins (trans protection) or through chemical modification of the phosphodiester backbone (phosphorothioate RNA;
Birgit, Scheel +8 more
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Salt-Dependent RNA Pseudoknot Stability: Effect of Spatial Confinement
Frontiers in Molecular Biosciences, 2021 Macromolecules, such as RNAs, reside in crowded cell environments, which could strongly affect the folded structures and stability of RNAs. The emergence of RNA-driven phase separation in biology further stresses the potential functional roles of ...
Chenjie Feng +4 more
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A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans
eLife, 2020 piRNAs play a critical role in the regulation of transposons and other germline genes. In Caenorhabditis elegans, regulation of piRNA target genes is mediated by the mutator complex, which synthesizes high levels of siRNAs through the activity of an RNA ...
Kevin I Manage +12 more
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Characterization of RNA hairpin loop stability [PDF]
Nucleic Acids Research, 1988 Fifteen RNA hairpins that share the same stem sequence and have homopolymer loops of A, C and U residues which vary in length from three to nine nucleotides were synthesized and their thermal stabilities determined. Tm varies as a function of loop size but is almost independent of loop composition.
D R, Groebe, O C, Uhlenbeck
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Targeted mRNA demethylation in Arabidopsis using plant m6A editor
Plant Methods, 2023 Background N6-methyladenosine (m6A) is an important epigenetic modification involved in RNA stability and translation regulation. Manipulating the expression of RNA m6A methyltransferases or demethylases makes it difficult to study the effect of specific
Ruiqiu Fang +3 more
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Cell & Bioscience, 2022 RNA is spliced concomitantly with transcription and the process is organized by RNA splicing factors, transcriptional regulators, and chromatin regulators. RNA is spliced in close proximity to transcription machinery. Hence, some RNA splicing factors may
Koji Kitamura +6 more
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Abnormal RNA stability in amyotrophic lateral sclerosis
Nature Communications, 2018 RNA instability may be a contributing factor in amyotrophic lateral sclerosis (ALS). Here the authors carry out genome-wide assessment of RNA synthesis and stability in cells derived from patients with C9orf72 ALS, sporadic ALS and healthy controls.
E. M. Tank +16 more
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