Results 21 to 30 of about 4,719,315 (357)
Reversible 2′-OH acylation enhances RNA stability
Nature Chemistry, 2023 Stabilization of RNAs for storage, transport and biological application remains a profound challenge. Now, it has been shown that reversible 2′-OH acylation with easily accessible acylimidazoles unlocks efficient protection of RNA. RNA can be deprotected
L. Fang +4 more
semanticscholar +1 more source
Borate Minerals and RNA Stability [PDF]
Polymers, 2010 The abiotic origin of genetic polymers faces two major problems: a prebiotically plausible polymerization mechanism and the maintenance of their polymerized state outside a cellular environment. The stabilizing action of borate on ribose having been reported, we have explored the possibility that borate minerals stabilize RNA.
Cristina Cossetti +3 more
openaire +5 more sources
Incoherent dual regulation by a SAM-II riboswitch controlling translation at a distance
RNA Biology, 2022 In Sinorhizobium meliloti, the methionine biosynthesis genes metA and metZ are preceded by S-adenosyl-L-methionine (SAM) riboswitches of the SAM-II class. Upon SAM binding, structural changes in the metZ riboswitch were predicted to cause transcriptional
Robina Scheuer +5 more
doaj +1 more source
VfoldCPX Server: Predicting RNA-RNA Complex Structure and Stability. [PDF]
PLoS ONE, 2016 RNA-RNA interactions are essential for genomic RNA dimerization, mRNA splicing, and many RNA-related gene expression and regulation processes. The prediction of the structure and folding stability of RNA-RNA complexes is a problem of significant ...
Xiaojun Xu, Shi-Jie Chen
doaj +1 more source
Effects of Nanoparticles on Double-Stranded RNA Stability in Corn Soil [PDF]
, 2018 Double-stranded RNA (dsRNA) can potentially be used as a pesticide because these molecules trigger an immune response called RNA interference (RNAi). If the expression of essential genes matching the dsRNA sequence are silenced, then the pest dies.
Reyanldo, Miriam +7 more
core +5 more sources
Predicting 3D structure and stability of RNA pseudoknots in monovalent and divalent ion solutions. [PDF]
PLoS Computational Biology, 2018 RNA pseudoknots are a kind of minimal RNA tertiary structural motifs, and their three-dimensional (3D) structures and stability play essential roles in a variety of biological functions.
Ya-Zhou Shi +4 more
doaj +1 more source
Repression of PUM1-mediated mRNA decay activates translesion synthesis after DNA damage
Molecular & Cellular Oncology, 2020 Biological roles of Pumilio1 (PUM1) in ubiquitous cells remain unclear. Here we identify 48 degrading target mRNAs by combined analysis of transcriptome-wide mRNA stabilities and the binding of mRNAs.
Toshimichi Yamada +2 more
doaj +1 more source
RNA Stability Measurements Using RT-qPCR in Arabidopsis Seedlings. [PDF]
Bio Protoc, 2020 Steady-state mRNA levels are determined by both the rates of transcription and degradation. Regulation of mRNA stability and/or degradation are key factors that can significantly affect mRNA levels and its biological functions.
Jia T, Le BH.
europepmc +2 more sources
m6A-dependent regulation of messenger RNA stability
Nature, 2013 N6-methyladenosine (m6A) is the most prevalent internal (non-cap) modification present in the messenger RNA of all higher eukaryotes. Although essential to cell viability and development, the exact role of m6A modification remains to be determined.
Xiao Wang +12 more
semanticscholar +1 more source
Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer's disease. [PDF]
, 2017 The abundance of mRNA is mainly determined by the rates of RNA transcription and decay. Here, we present a method for unbiased estimation of differential mRNA decay rate from RNA-sequencing data by modeling the kinetics of mRNA metabolism.
Alkallas, Rached +3 more
core +3 more sources